Assessment of buccal mucosa genotoxicity in insecticide-exposed urban fumigators in Cali, Colombia

Elizabeth Londoño-Velasco, Helberg Asencio-Santofimio, Jose Guillermo Ortega-Avila, Aldair Beryery Rosero-Caldón, Juan Carlos Aristizabal-Grisales, Laura Rey-Henao, Jairo Andres Vargas-Rivera, Enrique Vergara-Escudero

Producción: Contribución a una revistaArtículorevisión exhaustiva


Objectives: This study aimed to evaluate cytogenetic damage in the buccal mucosa of non-exposed subjects (N = 33) and insecticide-exposed fumigators (N = 31) in the urban area of Cali, Colombia. Material and Methods: Through a questionnaire sociodemographic data, anthropometric measurements, state of health, and lifestyle were collected. Buccal micronucleus cytome (BMCyt) assay was using for evaluate cytogenetic damage. Results: The study showed that all fumigators used adequate personal protective equipment (PPE) and had low alcohol consumption. The authors did not find significant differences in BMCyt biomarkers between the groups (p > 0.05). Multivariate analysis showed a 13% increase in micronucleus (MN) frequency for every year of increasing age (OR = 1.13, p = 0.029), and higher MN with the decrease in daily fruit consumption (OR = 4.71, p = 0.084), without statistical significance. Conclusions: The results between groups could be related to healthy habits and PPE use among the subjects.

Idioma originalInglés
Páginas (desde-hasta)128-137
Número de páginas10
PublicaciónInternational Journal of Occupational Medicine and Environmental Health
EstadoPublicada - 23 ene. 2024


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