TY - JOUR
T1 - Assessment of buccal mucosa genotoxicity in insecticide-exposed urban fumigators in Cali, Colombia
AU - Londoño-Velasco, Elizabeth
AU - Asencio-Santofimio, Helberg
AU - Ortega-Avila, Jose Guillermo
AU - Rosero-Caldón, Aldair Beryery
AU - Aristizabal-Grisales, Juan Carlos
AU - Rey-Henao, Laura
AU - Vargas-Rivera, Jairo Andres
AU - Vergara-Escudero, Enrique
N1 - Publisher Copyright:
© 2024 Nofer Institute of Occupational Medicine. All rights reserved.
PY - 2024/1/23
Y1 - 2024/1/23
N2 - Objectives: This study aimed to evaluate cytogenetic damage in the buccal mucosa of non-exposed subjects (N = 33) and insecticide-exposed fumigators (N = 31) in the urban area of Cali, Colombia. Material and Methods: Through a questionnaire sociodemographic data, anthropometric measurements, state of health, and lifestyle were collected. Buccal micronucleus cytome (BMCyt) assay was using for evaluate cytogenetic damage. Results: The study showed that all fumigators used adequate personal protective equipment (PPE) and had low alcohol consumption. The authors did not find significant differences in BMCyt biomarkers between the groups (p > 0.05). Multivariate analysis showed a 13% increase in micronucleus (MN) frequency for every year of increasing age (OR = 1.13, p = 0.029), and higher MN with the decrease in daily fruit consumption (OR = 4.71, p = 0.084), without statistical significance. Conclusions: The results between groups could be related to healthy habits and PPE use among the subjects.
AB - Objectives: This study aimed to evaluate cytogenetic damage in the buccal mucosa of non-exposed subjects (N = 33) and insecticide-exposed fumigators (N = 31) in the urban area of Cali, Colombia. Material and Methods: Through a questionnaire sociodemographic data, anthropometric measurements, state of health, and lifestyle were collected. Buccal micronucleus cytome (BMCyt) assay was using for evaluate cytogenetic damage. Results: The study showed that all fumigators used adequate personal protective equipment (PPE) and had low alcohol consumption. The authors did not find significant differences in BMCyt biomarkers between the groups (p > 0.05). Multivariate analysis showed a 13% increase in micronucleus (MN) frequency for every year of increasing age (OR = 1.13, p = 0.029), and higher MN with the decrease in daily fruit consumption (OR = 4.71, p = 0.084), without statistical significance. Conclusions: The results between groups could be related to healthy habits and PPE use among the subjects.
KW - biomarker
KW - buccal micronucleus cytome assay
KW - DNA damage
KW - insecticides
KW - occupational exposure
KW - personal protective equipment
UR - http://www.scopus.com/inward/record.url?scp=85186962368&partnerID=8YFLogxK
U2 - 10.13075/ijomeh.1896.02292
DO - 10.13075/ijomeh.1896.02292
M3 - Article
C2 - 38264916
SN - 1232-1087
VL - 37
SP - 128
EP - 137
JO - International Journal of Occupational Medicine and Environmental Health
JF - International Journal of Occupational Medicine and Environmental Health
IS - 1
ER -
