Evaluacion del daño genotoxico y citotoxico en celulas epiteliales de la cavidad bucal de hombres adultos expuestos ocupacionalmente a insecticidas organofosforados y piretroides en la ciudad de Cali.

Proyecto: Investigación

Detalles del proyecto


Pyrethroids and organophosphate insecticides are a heterogeneous category of chemicals designed to control pests and vectors. Some studies have shown that these compounds may have mutagenic and genotoxic, teratogenic, hepatotoxic, neurotoxic, ecotoxic, reproductive and hormonal effects and carcinogenic potential. all people are exposed to insecticides, but the operators involved in the massive chemical spraying for vector control are subjects that have major risk of exposure due to their occupation. However, there are not enough reports about relationship between occupational exposure to insecticides and DNa damage, or the risk of developing chronic diseases such as cancer. Therefore, the objective of this study is to evaluate the frequency of micronuclei (genotoxic damage) in epithelial cells of the buccal cavity of adult men, occupationally exposed to pyrethroids and organophosphate, insecticides used for chemical control of arboviruses vectors in Cali city. To achieve this aim, we propose a cross-sectional study in healthy adult men, workers in fumigations. Genotoxic damage will assessment in epithelial cells by Buccal Micronucleus Cytome (BMCyt) assay. Micronuclei frequency will be compared between exposed and reference (no-exposed occupationally) group. The results obtained in this study will contribute to the generation of new knowledge, that could contribute in the implementation of epidemiological surveillance programs to identify occupationally vulnerable sectors and determine their possible genetic susceptibility; this study also could offer data of interest in public health for handling of insecticides as preponderant environmental factors for induction of harmful effects on the genome.
Fecha de inicio/Fecha fin01/02/1715/12/17

Estado del Proyecto

  • Terminado