Evaluacion de los efectos cardiomoduladores y antinocieptivos en modelo murino, de la fraccion metanolica, de zanthoxylum rohifolium (rutaceae), presente en el Valle del Cauca, Colombia.

The aim of this research is to identify potential cardiomodulares, antihypertensives and antinociceptive compounds from seeds of Zanthoxylum rohifolium (Rutaceae) which is located in the department of Valle del Cauca (Colombia). Zanthoxylum genus comprises about 549 species of trees and shrubs in tropical and temperate regions. The fruit and bark of this plant have been used in traditional medicine as an analgesic, antipyretic, antibiotic, anti-tumor and anti-malarial. Based on it, several studies we have been performed with different species of the genus Zanthoxylum, where it has been found that the administration of ethanolic extract of bark Z. riedelianum inhibits activation of nociceptive afferents in the test formalin performed in Wistar rats. On the other hand, in China they have been patented drugs like Zhuyejiao, used for the treatment of acute appendicitis, abdominal pain and stomach aches. Moreover, compounds of Z. armatun as eudesmina, fargesina, kobusina and sesamin, among others, may be responsible for its potent antinociceptive and antiinflammatory activity. The vasorelaxants antihypertensive effects of ethanolic extract of Z. rohifolium’s branches have been recognized in rats. This extract induced hypotension and decreased heart rate in normotensive rats (Ferreira et al., 2013) Despite the numerous studies on plants of this kind worldwide, few have been conducted on the different species of this genus found in Colombia, as with Z. rhoifolium and have not been evaluated antinociceptive effects on blood pressure and heart rate of the methanol fraction of the fruits of this species. In this sense we propose to study whether Z. rhoifolium has compounds that may have similar activity as the species in other countries. We will do phytochemical extraction in order to obtain aqueous and ethanolic extracts of the fruits of Z. rhoifolium, and evaluate them employing biomodels (Swiss albino mice). Through this project we seek to continue research in natural products. Research topic that have been done by Research Group in Health Basic and Clinical Sciences from Pontificia Universidad Javeriana Cali and Group of Pharmacology from Universidad del Valle.