Tumor infiltrating lymphocytes (TILs) are a prognosis biomarker in Colombian patients with triple negative breast cancer

Carlos A Huertas-Caro; Mayra A Ramírez; Laura Rey-Vargas; Lina María Bejarano-Rivera; Diego Felipe Ballen; Marcela Nuñez; Juan Carlos Mejía; Luz Fernanda Sua-Villegas; Alicia Cock-Rada; Jovanny Zabaleta; Laura Fejerman; María Carolina Sanabria-Salas; Silvia J Serrano-Gomez

doi:10.1038/s41598-023-48300-4

Tumor infiltrating lymphocytes (TILs) are a prognosis biomarker in Colombian patients with triple negative breast cancer

Título traducido de la contribución: Los linfocitos infiltrantes tumorales (TIL) son un biomarcador pronóstico en pacientes colombianas con cáncer de mama triple negativo

Carlos A Huertas-Caro
, Mayra A Ramírez
, Laura Rey-Vargas
, Lina María Bejarano-Rivera
, Diego Felipe Ballen
, Marcela Nuñez
, Juan Carlos Mejía
, Luz Fernanda Sua-Villegas
, Alicia Cock-Rada
, Jovanny Zabaleta
, Laura Fejerman
, María Carolina Sanabria-Salas
, Silvia J Serrano-Gomez

Instituto Nacional de Cancerología - Colombia
Pontificia Universidad Javeriana
Fundación Valle del Lili
Universidad ICESI
Instituto de Cancerología, Las Américas
Louisiana State University Health Sciences Center
University of California at Davis

Producción: Contribución a una revista › Artículo › revisión exhaustiva

26 Citas (Scopus)

Resumen

El cáncer de mama triple negativo (CMTN) es altamente inmunogénico y los altos niveles de linfocitos infiltrantes tumorales (TIL) se han asociado con un mejor pronóstico y una mayor probabilidad de lograr una respuesta patológica completa. Aquí, exploramos el papel potencial del nivel y la composición de TIL estromales como un biomarcador pronóstico y predictivo en CMTN. Se incluyeron 195 bioespecímenes tumorales de pacientes diagnosticados con CMTN. Se evaluaron TIL estromales (sTIL), células CD4/CD8 positivas. Se evaluaron las diferencias en las características clínico-patológicas según la infiltración inmune. El valor predictivo y pronóstico de la infiltración inmune se analizó mediante modelos multivariados. Se observó una mayor infiltración inmune en pacientes con características clínico-patológicas favorables. El análisis de supervivencia mostró que se observaron tiempos de supervivencia general más largos en pacientes con una mayor infiltración de sTIL (p = 0,00043), CD4 + (p = 0,0074) y CD8 + (p = 0,008). En el análisis multivariante, se observó que los niveles bajos de sTIL se asociaban con un mayor riesgo de mortalidad (HR: 1,59; IC del 95 %: 1,01-2,48). La infiltración inmunitaria de CD4 y CD8 se asoció con una mayor probabilidad de respuesta patológica completa (OR: 1,20; IC del 95 %: 1,00-1,46; OR: 1,28; 1,02-1,65, respectivamente). Nuestros resultados sugieren que la infiltración inmunitaria podría utilizarse como marcador pronóstico de supervivencia global en pacientes con CMTN.

Título traducido de la contribución	Los linfocitos infiltrantes tumorales (TIL) son un biomarcador pronóstico en pacientes colombianas con cáncer de mama triple negativo
Idioma original	Inglés
Número de artículo	21324
Páginas (desde-hasta)	1-11
Número de páginas	11
Publicación	Scientific Reports
Volumen	13
N.º	1
DOI	https://doi.org/10.1038/s41598-023-48300-4
Estado	Publicada - 03 dic 2023
Publicado de forma externa	Sí

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

ODS 3: Salud y bienestar

Palabras clave

Biomarcadores
Biomarcadores tumorales
Colombia
Humanos
Linfocitos infiltrantes de tumores
Pronóstico
Neoplasias mamarias triple negativas

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Huertas-Caro, C. A., Ramírez, M. A., Rey-Vargas, L., Bejarano-Rivera, L. M., Ballen, D. F., Nuñez, M., Mejía, J. C., Sua-Villegas, L. F., Cock-Rada, A., Zabaleta, J., Fejerman, L., Sanabria-Salas, M. C., & Serrano-Gomez, S. J. (2023). Tumor infiltrating lymphocytes (TILs) are a prognosis biomarker in Colombian patients with triple negative breast cancer. Scientific Reports, 13(1), 1-11. Artículo 21324. https://doi.org/10.1038/s41598-023-48300-4

@article{f147743209bd43f4921404401cdc9de2,

title = "Tumor infiltrating lymphocytes (TILs) are a prognosis biomarker in Colombian patients with triple negative breast cancer",

abstract = "Triple negative breast cancer (TNBC) is highly immunogenic and high levels of tumor infiltrating lymphocytes (TILs) have been associated with a better prognosis and higher probability to achieve pathological complete response. Here, we explore the potential role of stromal TILs level and composition as a prognostic and predictive biomarker in TNBC. 195 Tumor biospecimens from patients diagnosed with TNBC were included. Stromal TILs (sTILs), positive CD4/CD8 cells were evaluated. Differences in clinic-pathological characteristics according to immune infiltration were assessed. The predictive and prognostic value of immune infiltration was analyzed by multivariate models. Higher immune infiltration was observed in patients with favorable clinical{\textendash}pathological features. Survival analysis showed that longer overall survival times were observed in patients with a higher infiltration of sTILs (p = 0.00043), CD4 + (p = 0.0074) and CD8 + (p = 0.008). In the multivariate analysis, low levels of sTILs were found to be associated with a higher mortality hazard (HR: 1.59, 95\% CI 1.01{\textendash}2.48). CD4 and CD8 immune infiltration were associated with higher odds for pathological complete response (OR: 1.20, 95\% CI 1.00{\textendash}1.46, OR: 1.28, 1.02{\textendash}1.65, respectively). Our results suggest that immune infiltration could be used as a prognostic marker for overall survival in TNBC patients.",

keywords = "Biomarkers, Tumor, Colombia, Humans, Lymphocytes, Tumor-Infiltrating, Prognosis, Triple Negative Breast Neoplasms, Biomarcadores, Biomarcadores tumorales, Colombia, Humanos, Linfocitos infiltrantes de tumores, Pron{\'o}stico, Neoplasias mamarias triple negativas",

author = "Huertas-Caro, \{Carlos A\} and Ram{\'i}rez, \{Mayra A\} and Laura Rey-Vargas and Bejarano-Rivera, \{Lina Mar{\'i}a\} and Ballen, \{Diego Felipe\} and Marcela Nu{\~n}ez and Mej{\'i}a, \{Juan Carlos\} and Sua-Villegas, \{Luz Fernanda\} and Alicia Cock-Rada and Jovanny Zabaleta and Laura Fejerman and Sanabria-Salas, \{Mar{\'i}a Carolina\} and Serrano-Gomez, \{Silvia J\}",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

month = dec,

day = "3",

doi = "10.1038/s41598-023-48300-4",

language = "English",

volume = "13",

pages = "1--11",

journal = "Scientific Reports",

issn = "2045-2322",

number = "1",

}

Huertas-Caro, CA, Ramírez, MA, Rey-Vargas, L, Bejarano-Rivera, LM, Ballen, DF, Nuñez, M, Mejía, JC, Sua-Villegas, LF, Cock-Rada, A, Zabaleta, J, Fejerman, L, Sanabria-Salas, MC & Serrano-Gomez, SJ 2023, 'Tumor infiltrating lymphocytes (TILs) are a prognosis biomarker in Colombian patients with triple negative breast cancer', Scientific Reports, vol. 13, n.º 1, 21324, pp. 1-11. https://doi.org/10.1038/s41598-023-48300-4

TY - JOUR

T1 - Tumor infiltrating lymphocytes (TILs) are a prognosis biomarker in Colombian patients with triple negative breast cancer

AU - Huertas-Caro, Carlos A

AU - Ramírez, Mayra A

AU - Rey-Vargas, Laura

AU - Bejarano-Rivera, Lina María

AU - Ballen, Diego Felipe

AU - Nuñez, Marcela

AU - Mejía, Juan Carlos

AU - Sua-Villegas, Luz Fernanda

AU - Cock-Rada, Alicia

AU - Zabaleta, Jovanny

AU - Fejerman, Laura

AU - Sanabria-Salas, María Carolina

AU - Serrano-Gomez, Silvia J

PY - 2023/12/3

Y1 - 2023/12/3

N2 - Triple negative breast cancer (TNBC) is highly immunogenic and high levels of tumor infiltrating lymphocytes (TILs) have been associated with a better prognosis and higher probability to achieve pathological complete response. Here, we explore the potential role of stromal TILs level and composition as a prognostic and predictive biomarker in TNBC. 195 Tumor biospecimens from patients diagnosed with TNBC were included. Stromal TILs (sTILs), positive CD4/CD8 cells were evaluated. Differences in clinic-pathological characteristics according to immune infiltration were assessed. The predictive and prognostic value of immune infiltration was analyzed by multivariate models. Higher immune infiltration was observed in patients with favorable clinical–pathological features. Survival analysis showed that longer overall survival times were observed in patients with a higher infiltration of sTILs (p = 0.00043), CD4 + (p = 0.0074) and CD8 + (p = 0.008). In the multivariate analysis, low levels of sTILs were found to be associated with a higher mortality hazard (HR: 1.59, 95% CI 1.01–2.48). CD4 and CD8 immune infiltration were associated with higher odds for pathological complete response (OR: 1.20, 95% CI 1.00–1.46, OR: 1.28, 1.02–1.65, respectively). Our results suggest that immune infiltration could be used as a prognostic marker for overall survival in TNBC patients.

AB - Triple negative breast cancer (TNBC) is highly immunogenic and high levels of tumor infiltrating lymphocytes (TILs) have been associated with a better prognosis and higher probability to achieve pathological complete response. Here, we explore the potential role of stromal TILs level and composition as a prognostic and predictive biomarker in TNBC. 195 Tumor biospecimens from patients diagnosed with TNBC were included. Stromal TILs (sTILs), positive CD4/CD8 cells were evaluated. Differences in clinic-pathological characteristics according to immune infiltration were assessed. The predictive and prognostic value of immune infiltration was analyzed by multivariate models. Higher immune infiltration was observed in patients with favorable clinical–pathological features. Survival analysis showed that longer overall survival times were observed in patients with a higher infiltration of sTILs (p = 0.00043), CD4 + (p = 0.0074) and CD8 + (p = 0.008). In the multivariate analysis, low levels of sTILs were found to be associated with a higher mortality hazard (HR: 1.59, 95% CI 1.01–2.48). CD4 and CD8 immune infiltration were associated with higher odds for pathological complete response (OR: 1.20, 95% CI 1.00–1.46, OR: 1.28, 1.02–1.65, respectively). Our results suggest that immune infiltration could be used as a prognostic marker for overall survival in TNBC patients.

KW - Biomarkers

KW - Tumor

KW - Colombia

KW - Humans

KW - Lymphocytes

KW - Tumor-Infiltrating

KW - Prognosis

KW - Triple Negative Breast Neoplasms

KW - Biomarcadores

KW - Biomarcadores tumorales

KW - Colombia

KW - Humanos

KW - Linfocitos infiltrantes de tumores

KW - Pronóstico

KW - Neoplasias mamarias triple negativas

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UR - https://www.scopus.com/pages/publications/85178449774

U2 - 10.1038/s41598-023-48300-4

DO - 10.1038/s41598-023-48300-4

M3 - Article

C2 - 38044375

SN - 2045-2322

VL - 13

SP - 1

EP - 11

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 21324

ER -

Tumor infiltrating lymphocytes (TILs) are a prognosis biomarker in Colombian patients with triple negative breast cancer

Resumen

ODS de las Naciones Unidas

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