TY - JOUR
T1 - Transferable vancomycin resistance in a community-associated MRSA lineage
AU - Rossi, Flávia
AU - Diaz, Lorena
AU - Wollam, Aye
AU - Panesso, Diana
AU - Zhou, Yanjiao
AU - Rincon, Sandra
AU - Narechania, Apurva
AU - Xing, Galen
AU - Di Gioia, Thais S.R.
AU - Doi, André
AU - Tran, Truc T.
AU - Reyes, Jinnethe
AU - Munita, Jose M.
AU - Carvajal, Lina P.
AU - Hernandez-Roldan, Alejandra
AU - Brandão, Denise
AU - Van Der Heijden, Inneke Marie
AU - Murray, Barbara E.
AU - Planet, Paul J.
AU - Weinstock, George M.
AU - Arias, Cesar A.
PY - 2014
Y1 - 2014
N2 - We report the case of a patient from Brazil with a bloodstream infection caused by a strain of methicillin-resistant Staphylococcus aureus (MRSA) that was susceptible to vancomycin (designated BR-VSSA) but that acquired the vanA gene cluster during antibiotic therapy and became resistant to vancomycin (designated BR-VRSA). Both strains belong to the sequence type (ST) 8 community-associated genetic lineage that carries the staphylococcal chromosomal cassette mec (SCCmec) type IVa and the S. aureus protein A gene (spa) type t292 and are phylogenetically related to MRSA lineage USA300. A conjugative plasmid of 55,706 bp (pBRZ01) carrying the vanA cluster was identified and readily transferred to other staphylococci. The pBRZ01 plasmid harbors DNA sequences that are typical of the plasmid-associated replication genes rep24 or rep21 described in community-associated MRSA strains from Australia (pWBG745). The presence and dissemination of community-associated MRSA containing vanA could become a serious public health concern.
AB - We report the case of a patient from Brazil with a bloodstream infection caused by a strain of methicillin-resistant Staphylococcus aureus (MRSA) that was susceptible to vancomycin (designated BR-VSSA) but that acquired the vanA gene cluster during antibiotic therapy and became resistant to vancomycin (designated BR-VRSA). Both strains belong to the sequence type (ST) 8 community-associated genetic lineage that carries the staphylococcal chromosomal cassette mec (SCCmec) type IVa and the S. aureus protein A gene (spa) type t292 and are phylogenetically related to MRSA lineage USA300. A conjugative plasmid of 55,706 bp (pBRZ01) carrying the vanA cluster was identified and readily transferred to other staphylococci. The pBRZ01 plasmid harbors DNA sequences that are typical of the plasmid-associated replication genes rep24 or rep21 described in community-associated MRSA strains from Australia (pWBG745). The presence and dissemination of community-associated MRSA containing vanA could become a serious public health concern.
UR - http://www.scopus.com/inward/record.url?scp=84898636251&partnerID=8YFLogxK
U2 - 10.1056/NEJMoa1303359
DO - 10.1056/NEJMoa1303359
M3 - Article
C2 - 24738669
AN - SCOPUS:84898636251
SN - 0028-4793
VL - 370
SP - 1524
EP - 1531
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 16
ER -
