Toxicity, Teratogenicity and Anti-cancer Activity of Alpha-Solanine: A Perspective on Anti-cancer Potential

Adriana Ordoñez Vasquez; Víctor Aguirre-Arzola; Myriam Angélica de la Garza-Ramos; Victor Hugo Urrutia-Baca; Fernando Suárez Obando

doi:10.3923/ijp.2019.301.310

Toxicity, Teratogenicity and Anti-cancer Activity of Alpha-Solanine: A Perspective on Anti-cancer Potential

Adriana Ordoñez Vasquez
, Víctor Aguirre-Arzola
, Myriam Angélica de la Garza-Ramos
, Victor Hugo Urrutia-Baca
, Fernando Suárez Obando

Instituto de Genética Humana

Universidad Autonoma de Nuevo Leon
Pontificia Universidad Javeriana

Producción: Contribución a una revista › Artículo › revisión exhaustiva

Resumen

The Alpha-Solanine is a glycoalkaloid metabolite produced by solanaceae species, important plant food in the human nutrition. This
alpha-solanine is highly toxic to animals and humans and has been indicated as a risk factor for developing congenital malformations.
However, recent studies suggest that alpha-solanine possesses anti-microbial and anti-tumor activities. The aim of this review was to
summarize the main properties of alpha-solanine, its toxicity and teratogenicity in animal models and the main findings reported about anticancer activity against various cancer cell lines in in vitro assays. Key alpha-solanine mechanisms of action are presented alongside arising
interdisciplinary research, connecting agricultural sciences and medicine. Data presented in this review, may assisted in preventing toxic
effects of alpha-solanine and promote research about its potential use in the treatment and management of human cancers.

Idioma original	Inglés
Páginas (desde-hasta)	301-310
Número de páginas	11
Publicación	INTERNATIONAL JOURNAL OF PHARMACOLOGY
Volumen	15
N.º	3
DOI	https://doi.org/10.3923/ijp.2019.301.310
Estado	Publicada - 2019

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title = "Toxicity, Teratogenicity and Anti-cancer Activity of Alpha-Solanine: A Perspective on Anti-cancer Potential",

abstract = "The Alpha-Solanine is a glycoalkaloid metabolite produced by solanaceae species, important plant food in the human nutrition. This alpha-solanine is highly toxic to animals and humans and has been indicated as a risk factor for developing congenital malformations. However, recent studies suggest that alpha-solanine possesses anti-microbial and anti-tumor activities. The aim of this review was to summarize the main properties of alpha-solanine, its toxicity and teratogenicity in animal models and the main findings reported about anticancer activity against various cancer cell lines in in vitro assays. Key alpha-solanine mechanisms of action are presented alongside arising interdisciplinary research, connecting agricultural sciences and medicine. Data presented in this review, may assisted in preventing toxic effects of alpha-solanine and promote research about its potential use in the treatment and management of human cancers.",

author = "\{Ordo{\~n}ez Vasquez\}, Adriana and V{\'i}ctor Aguirre-Arzola and \{de la Garza-Ramos\}, \{Myriam Ang{\'e}lica\} and Urrutia-Baca, \{Victor Hugo\} and \{Su{\'a}rez Obando\}, Fernando",

year = "2019",

doi = "10.3923/ijp.2019.301.310",

language = "English",

volume = "15",

pages = "301--310",

journal = "INTERNATIONAL JOURNAL OF PHARMACOLOGY",

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T2 - A Perspective on Anti-cancer Potential

AU - Ordoñez Vasquez, Adriana

AU - Aguirre-Arzola, Víctor

AU - de la Garza-Ramos, Myriam Angélica

AU - Urrutia-Baca, Victor Hugo

AU - Suárez Obando, Fernando

PY - 2019

Y1 - 2019

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DO - 10.3923/ijp.2019.301.310

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Toxicity, Teratogenicity and Anti-cancer Activity of Alpha-Solanine: A Perspective on Anti-cancer Potential

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