Synthesis of 198Au nanoparticles sub 10 nm due optimization on local dose by Monte Carlo simulations for cancer treatment

Julián Mateo Zutta Villate; Jessika Viviana Rojas; Marc Benjamin Hahn; Jorge Anselmo Puerta

doi:10.1007/s10967-022-08355-5

Synthesis of ¹⁹⁸Au nanoparticles sub 10 nm due optimization on local dose by Monte Carlo simulations for cancer treatment

Julián Mateo Zutta Villate
, Jessika Viviana Rojas
, Marc Benjamin Hahn
, Jorge Anselmo Puerta

Departamento de Física

Virginia Commonwealth University
Federal Institute for Materials Research and Testing Berlin
Universidad Nacional de Colombia

Producción: Contribución a una revista › Artículo › revisión exhaustiva

3 Citas (Scopus)

Resumen

To enhance the biological effects of radiation damage in cancerous cells, we present an alternative approach to the use of gold nanoparticles (AuNP), focusing on the synthesis and characterization of highly monodisperse, spherical radioactive gold nanoparticles ¹⁹⁸AuNP. The size of the AuNP size was optimized with the help of Geant4/TOPAS particle scattering simulations, and energy deposition per nm³ per decay for varying radii (2–10 nm) was evaluated. This work is the foundation for ongoing experimental work to evaluate cell death induced by ¹⁹⁸AuNP which aims for the use of radioactive gold nanoparticles in cancer treatment.

Idioma original	Inglés
Páginas (desde-hasta)	3033-3041
Número de páginas	9
Publicación	Journal of Radioanalytical and Nuclear Chemistry
Volumen	331
N.º	7
DOI	https://doi.org/10.1007/s10967-022-08355-5
Estado	Publicada - jul. 2022

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title = "Synthesis of 198Au nanoparticles sub 10 nm due optimization on local dose by Monte Carlo simulations for cancer treatment",

abstract = "To enhance the biological effects of radiation damage in cancerous cells, we present an alternative approach to the use of gold nanoparticles (AuNP), focusing on the synthesis and characterization of highly monodisperse, spherical radioactive gold nanoparticles 198AuNP. The size of the AuNP size was optimized with the help of Geant4/TOPAS particle scattering simulations, and energy deposition per nm3 per decay for varying radii (2–10 nm) was evaluated. This work is the foundation for ongoing experimental work to evaluate cell death induced by 198AuNP which aims for the use of radioactive gold nanoparticles in cancer treatment.",

keywords = "Dose enhancement, Nanomaterial synthesis, Neutron activation, Nuclear Medicine, Radioactive gold nanoparticles",

author = "Villate, \{Juli{\'a}n Mateo Zutta\} and Rojas, \{Jessika Viviana\} and Hahn, \{Marc Benjamin\} and Puerta, \{Jorge Anselmo\}",

note = "Publisher Copyright: {\textcopyright} 2022, Akad{\'e}miai Kiad{\'o}, Budapest, Hungary.",

year = "2022",

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language = "English",

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Synthesis of ¹⁹⁸Au nanoparticles sub 10 nm due optimization on local dose by Monte Carlo simulations for cancer treatment. / Villate, Julián Mateo Zutta; Rojas, Jessika Viviana; Hahn, Marc Benjamin et al.
En: Journal of Radioanalytical and Nuclear Chemistry, Vol. 331, N.º 7, 07.2022, p. 3033-3041.

Producción: Contribución a una revista › Artículo › revisión exhaustiva

TY - JOUR

T1 - Synthesis of 198Au nanoparticles sub 10 nm due optimization on local dose by Monte Carlo simulations for cancer treatment

AU - Villate, Julián Mateo Zutta

AU - Rojas, Jessika Viviana

AU - Hahn, Marc Benjamin

AU - Puerta, Jorge Anselmo

PY - 2022/7

Y1 - 2022/7

N2 - To enhance the biological effects of radiation damage in cancerous cells, we present an alternative approach to the use of gold nanoparticles (AuNP), focusing on the synthesis and characterization of highly monodisperse, spherical radioactive gold nanoparticles 198AuNP. The size of the AuNP size was optimized with the help of Geant4/TOPAS particle scattering simulations, and energy deposition per nm3 per decay for varying radii (2–10 nm) was evaluated. This work is the foundation for ongoing experimental work to evaluate cell death induced by 198AuNP which aims for the use of radioactive gold nanoparticles in cancer treatment.

AB - To enhance the biological effects of radiation damage in cancerous cells, we present an alternative approach to the use of gold nanoparticles (AuNP), focusing on the synthesis and characterization of highly monodisperse, spherical radioactive gold nanoparticles 198AuNP. The size of the AuNP size was optimized with the help of Geant4/TOPAS particle scattering simulations, and energy deposition per nm3 per decay for varying radii (2–10 nm) was evaluated. This work is the foundation for ongoing experimental work to evaluate cell death induced by 198AuNP which aims for the use of radioactive gold nanoparticles in cancer treatment.

KW - Dose enhancement

KW - Nanomaterial synthesis

KW - Neutron activation

KW - Nuclear Medicine

KW - Radioactive gold nanoparticles

UR - https://www.scopus.com/pages/publications/85131879307

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SP - 3033

EP - 3041

JO - Journal of Radioanalytical and Nuclear Chemistry

JF - Journal of Radioanalytical and Nuclear Chemistry

IS - 7

ER -