@article{64f4d93bd0ee4fafbc18748745285478,
title = "Standardized evaluation framework for evaluating coronary artery stenosis detection, stenosis quantification and lumen segmentation algorithms in computed tomography angiography",
abstract = "Though conventional coronary angiography (CCA) has been the standard of reference for diagnosing coronary artery disease in the past decades, computed tomography angiography (CTA) has rapidly emerged, and is nowadays widely used in clinical practice. Here, we introduce a standardized evaluation framework to reliably evaluate and compare the performance of the algorithms devised to detect and quantify the coronary artery stenoses, and to segment the coronary artery lumen in CTA data. The objective of this evaluation framework is to demonstrate the feasibility of dedicated algorithms to: (1) (semi-)automatically detect and quantify stenosis on CTA, in comparison with quantitative coronary angiography (QCA) and CTA consensus reading, and (2) (semi-)automatically segment the coronary lumen on CTA, in comparison with expert's manual annotation. A database consisting of 48 multicenter multivendor cardiac CTA datasets with corresponding reference standards are described and made available. The algorithms from 11 research groups were quantitatively evaluated and compared. The results show that (1) some of the current stenosis detection/quantification algorithms may be used for triage or as a second-reader in clinical practice, and that (2) automatic lumen segmentation is possible with a precision similar to that obtained by experts. The framework is open for new submissions through the website, at http://coronary.bigr.nl/stenoses/.",
keywords = "Computed tomography angiography (CTA), Coronary arteries, Standardized evaluation framework, Stenoses detection, Stenoses quantification",
author = "Kiri{\c s}li, {H. A.} and M. Schaap and Metz, {C. T.} and Dharampal, {A. S.} and Meijboom, {W. B.} and Papadopoulou, {S. L.} and A. Dedic and K. Nieman and {de Graaf}, {M. A.} and Meijs, {M. F.L.} and Cramer, {M. J.} and A. Broersen and S. Cetin and A. Eslami and L. Fl{\'o}rez-Valencia and Lor, {K. L.} and B. Matuszewski and I. Melki and B. Mohr and I. {\"O}ks{\"u}z and R. Shahzad and C. Wang and Kitslaar, {P. H.} and G. Unal and A. Katouzian and M. Orkisz and Chen, {C. M.} and F. Precioso and L. Najman and S. Masood and D. {\"U}nay and {van Vliet}, L. and R. Moreno and R. Goldenberg and E. Vu{\c c}ini and Krestin, {G. P.} and Niessen, {W. J.} and {Van Walsum}, T.",
note = "Funding Information: Hortense Kiri{\c s}li is supported by a grant from the Dutch Ministry of Economic Affairs (AgentschapNL) under the title “Het Hart in Drie Dimensies” (translated to “Heart In 3D”, project PID06003). Coert Metz and Theo van Walsum are supported by a grant from the Information Technology for European Advancement (ITEA), under the title “Patient Friendly Medical Intervention” (Project 09039, Mediate). Wiro Niessen is supported by the Stichting voor Technische Wetenschappen (STW) of the Netherlands Organization of Scientific Research (NWO). ",
year = "2013",
month = dec,
doi = "10.1016/j.media.2013.05.007",
language = "English",
volume = "17",
pages = "859--876",
journal = "Medical Image Analysis",
issn = "1361-8415",
publisher = "Elsevier B.V.",
number = "8",
}