Sphingolipids and their role in health and disease in the central nervous system

Andrés Felipe Leal; Diego A. Suarez; Olga Yaneth Echeverri-Peña; Sonia Luz Albarracín; Carlos Javier Alméciga-Díaz; Ángela Johana Espejo-Mojica

doi:10.1016/j.jbior.2022.100900

Sphingolipids and their role in health and disease in the central nervous system

Andrés Felipe Leal, Diego A. Suarez, Olga Yaneth Echeverri-Peña, Sonia Luz Albarracín, Carlos Javier Alméciga-Díaz, Ángela Johana Espejo-Mojica

Universidad Javeriana

Producción: Contribución a una revista › Artículo de revisión › revisión exhaustiva

8 Citas (Scopus)

Resumen

Sphingolipids (SLs) are lipids derived from sphingosine, and their metabolism involves a broad and complex network of reactions. Although SLs are widely distributed in the body, it is well known that they are present in high concentrations within the central nervous system (CNS). Under physiological conditions, their abundance and distribution in the CNS depend on brain development and cell type. Consequently, SLs metabolism impairment may have a significant impact on the normal CNS function, and has been associated with several disorders, including sphingolipidoses, Parkinson's, and Alzheimer's. This review summarizes the main SLs characteristics and current knowledge about synthesis, catabolism, regulatory pathways, and their role in physiological and pathological scenarios in the CNS.

Idioma original	Inglés
Número de artículo	100900
Publicación	Advances in Biological Regulation
Volumen	85
DOI	https://doi.org/10.1016/j.jbior.2022.100900
Estado	Publicada - ago. 2022

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title = "Sphingolipids and their role in health and disease in the central nervous system",

abstract = "Sphingolipids (SLs) are lipids derived from sphingosine, and their metabolism involves a broad and complex network of reactions. Although SLs are widely distributed in the body, it is well known that they are present in high concentrations within the central nervous system (CNS). Under physiological conditions, their abundance and distribution in the CNS depend on brain development and cell type. Consequently, SLs metabolism impairment may have a significant impact on the normal CNS function, and has been associated with several disorders, including sphingolipidoses, Parkinson's, and Alzheimer's. This review summarizes the main SLs characteristics and current knowledge about synthesis, catabolism, regulatory pathways, and their role in physiological and pathological scenarios in the CNS.",

keywords = "Central nervous system, Lysosomal storage diseases, Sphingolipidoses, Sphingolipids",

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doi = "10.1016/j.jbior.2022.100900",

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volume = "85",

journal = "Advances in Biological Regulation",

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T1 - Sphingolipids and their role in health and disease in the central nervous system

AU - Leal, Andrés Felipe

AU - Suarez, Diego A.

AU - Echeverri-Peña, Olga Yaneth

AU - Albarracín, Sonia Luz

AU - Alméciga-Díaz, Carlos Javier

AU - Espejo-Mojica, Ángela Johana

PY - 2022/8

Y1 - 2022/8

N2 - Sphingolipids (SLs) are lipids derived from sphingosine, and their metabolism involves a broad and complex network of reactions. Although SLs are widely distributed in the body, it is well known that they are present in high concentrations within the central nervous system (CNS). Under physiological conditions, their abundance and distribution in the CNS depend on brain development and cell type. Consequently, SLs metabolism impairment may have a significant impact on the normal CNS function, and has been associated with several disorders, including sphingolipidoses, Parkinson's, and Alzheimer's. This review summarizes the main SLs characteristics and current knowledge about synthesis, catabolism, regulatory pathways, and their role in physiological and pathological scenarios in the CNS.

AB - Sphingolipids (SLs) are lipids derived from sphingosine, and their metabolism involves a broad and complex network of reactions. Although SLs are widely distributed in the body, it is well known that they are present in high concentrations within the central nervous system (CNS). Under physiological conditions, their abundance and distribution in the CNS depend on brain development and cell type. Consequently, SLs metabolism impairment may have a significant impact on the normal CNS function, and has been associated with several disorders, including sphingolipidoses, Parkinson's, and Alzheimer's. This review summarizes the main SLs characteristics and current knowledge about synthesis, catabolism, regulatory pathways, and their role in physiological and pathological scenarios in the CNS.

KW - Central nervous system

KW - Lysosomal storage diseases

KW - Sphingolipidoses

KW - Sphingolipids

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DO - 10.1016/j.jbior.2022.100900

M3 - Review article

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JO - Advances in Biological Regulation

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Sphingolipids and their role in health and disease in the central nervous system

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