TY - JOUR
T1 - Serum galanin levels in young healthy lean and obese non-diabetic men during an oral glucose tolerance test
AU - Sandoval-Alzate, Héctor Fabio
AU - Agudelo-Zapata, Yessica
AU - González-Clavijo, Angélica María
AU - Poveda, Natalia E.
AU - Espinel-Pachón, Cristian Felipe
AU - Escamilla-Castro, Jorge Augusto
AU - Márquez-Julio, Heidy Lorena
AU - Alvarado-Quintero, Hernando
AU - Rojas-Rodríguez, Fabián Guillermo
AU - Arteaga-Díaz, Juan Manuel
AU - Eslava-Schmalbach, Javier Hernando
AU - Garcés-Gutiérrez, Maria Fernanda
AU - Vrontakis, Maria
AU - Castaño, Justo P.
AU - Luque, Raul M.
AU - Diéguez, Carlos
AU - Nogueiras, Rubén
AU - Caminos, Jorge E.
N1 - Publisher Copyright:
© The Author(s) 2016.
PY - 2016/8/23
Y1 - 2016/8/23
N2 - Galanin (GAL) is a neuropeptide involved in the homeostasis of energy metabolism. The objective of this study was to investigate the serum levels of GAL during an oral glucose tolerance test (OGTT) in lean and obese young men. This cross-sectional study included 30 obese non-diabetic young men (median 22 years; mean BMI 37 kg/m 2) and 30 healthy lean men (median 23 years; mean BMI 22 kg/m 2). Serum GAL was determined during OGTT. The results of this study include that serum GAL levels showed a reduction during OGTT compared with basal levels in the lean subjects group. Conversely, serum GAL levels increased significantly during OGTT in obese subjects. Serum GAL levels were also higher in obese non-diabetic men compared with lean subjects during fasting and in every period of the OGTT (p < 0.001). Serum GAL levels were positively correlated with BMI, total fat, visceral fat, HOMA-IR, total cholesterol, triglycerides and Leptin. A multiple regression analysis revealed that serum insulin levels at 30, 60 and 120 minutes during the OGTT is the most predictive variable for serum GAL levels (p < 0.001). In conclusion, serum GAL levels are significantly higher in the obese group compared with lean subjects during an OGTT.
AB - Galanin (GAL) is a neuropeptide involved in the homeostasis of energy metabolism. The objective of this study was to investigate the serum levels of GAL during an oral glucose tolerance test (OGTT) in lean and obese young men. This cross-sectional study included 30 obese non-diabetic young men (median 22 years; mean BMI 37 kg/m 2) and 30 healthy lean men (median 23 years; mean BMI 22 kg/m 2). Serum GAL was determined during OGTT. The results of this study include that serum GAL levels showed a reduction during OGTT compared with basal levels in the lean subjects group. Conversely, serum GAL levels increased significantly during OGTT in obese subjects. Serum GAL levels were also higher in obese non-diabetic men compared with lean subjects during fasting and in every period of the OGTT (p < 0.001). Serum GAL levels were positively correlated with BMI, total fat, visceral fat, HOMA-IR, total cholesterol, triglycerides and Leptin. A multiple regression analysis revealed that serum insulin levels at 30, 60 and 120 minutes during the OGTT is the most predictive variable for serum GAL levels (p < 0.001). In conclusion, serum GAL levels are significantly higher in the obese group compared with lean subjects during an OGTT.
UR - http://www.scopus.com/inward/record.url?scp=84983542198&partnerID=8YFLogxK
U2 - 10.1038/srep31661
DO - 10.1038/srep31661
M3 - Article
C2 - 27550417
AN - SCOPUS:84983542198
SN - 2045-2322
VL - 6
JO - Scientific Reports
JF - Scientific Reports
M1 - 31661
ER -
