TY - JOUR
T1 - RUNX family
T2 - Oncogenes or tumor suppressors (Review)
AU - Otálora-Otálora, Beatriz Andrea
AU - Henríquez, Berta
AU - López-Kleine, Liliana
AU - Rojas, Adriana
N1 - Publisher Copyright:
© 2019 Spandidos Publications. All rights reserved.
PY - 2019/7
Y1 - 2019/7
N2 - Runt-related transcription factor (RUNX) proteins belong to a transcription factors family known as master regulators of important embryonic developmental programs. In the last decade, the whole family has been implicated in the regulation of different oncogenic processes and signaling pathways associated with cancer. Furthermore, a suppressor tumor function has been also reported, suggesting the RUNX family serves key role in all different types of cancer. In this review, the known biological characteristics, specific regulatory abilities and experimental evidence of RUNX proteins will be analyzed to demonstrate their oncogenic potential and tumor suppressor abilities during oncogenic processes, suggesting their importance as biomarkers of cancer. Additionally, the importance of continuing with the molecular studies of RUNX proteins' and its dual functions in cancer will be underlined in order to apply it in the future development of specific diagnostic methods and therapies against different types of cancer.
AB - Runt-related transcription factor (RUNX) proteins belong to a transcription factors family known as master regulators of important embryonic developmental programs. In the last decade, the whole family has been implicated in the regulation of different oncogenic processes and signaling pathways associated with cancer. Furthermore, a suppressor tumor function has been also reported, suggesting the RUNX family serves key role in all different types of cancer. In this review, the known biological characteristics, specific regulatory abilities and experimental evidence of RUNX proteins will be analyzed to demonstrate their oncogenic potential and tumor suppressor abilities during oncogenic processes, suggesting their importance as biomarkers of cancer. Additionally, the importance of continuing with the molecular studies of RUNX proteins' and its dual functions in cancer will be underlined in order to apply it in the future development of specific diagnostic methods and therapies against different types of cancer.
KW - Cancer
KW - Oncogenes
KW - Runt-related transcription factor
KW - Transcription factor
KW - Tumor suppressor
UR - http://www.scopus.com/inward/record.url?scp=85066766467&partnerID=8YFLogxK
U2 - 10.3892/or.2019.7149
DO - 10.3892/or.2019.7149
M3 - Review article
C2 - 31059069
AN - SCOPUS:85066766467
SN - 1021-335X
VL - 42
SP - 3
EP - 19
JO - Oncology Reports
JF - Oncology Reports
IS - 1
ER -
