Rotavirus specific plasma secretory immunoglobulin in children with acute gastroenteritis and children vaccinated with an attenuated human rotavirus vaccine

Daniel Herrera; Camilo Vásquez; Blaise Corthésy; Manuel A. Franco; Juana Angel

doi:10.4161/hv.25610

Rotavirus specific plasma secretory immunoglobulin in children with acute gastroenteritis and children vaccinated with an attenuated human rotavirus vaccine

Daniel Herrera, Camilo Vásquez, Blaise Corthésy, Manuel A. Franco, Juana Angel

Instituto de Genética Humana

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10 Citas (Scopus)

Resumen

Rotavirus (RV)-specific secretory immunoglobulin (RV-sIg) has been previously detected in serum of naturally RV infected children and shown to reflect the intestinal Ig immune response. Total plasma sIga and plasma RV-sIg were evaluated by eLIsa in children with gastroenteritis due or not due to RV infection and in 50 children vaccinated with the attenuated RIX4414 human RV vaccine and 62 placebo recipients. RV-sIg was only detected in children with evidence of previous RV infection or with acute RV gastroenteritis. Vaccinees had higher RV-sIg titers than placebo recipients and RV-sIg titers increased after the second vaccine dose. RV-sIg measured after the second dose correlated with protection when vaccinees and placebo recipients were analyzed jointly. RV-sIg may serve as a valuable correlate of protection for RV vaccines.

Idioma original	Inglés
Páginas (desde-hasta)	2409-2417
Número de páginas	9
Publicación	Human Vaccines and Immunotherapeutics
Volumen	9
N.º	11
DOI	https://doi.org/10.4161/hv.25610
Estado	Publicada - nov. 2013

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@article{83308f9d2662472da465b313778f3f77,

title = "Rotavirus specific plasma secretory immunoglobulin in children with acute gastroenteritis and children vaccinated with an attenuated human rotavirus vaccine",

abstract = "Rotavirus (RV)-specific secretory immunoglobulin (RV-sIg) has been previously detected in serum of naturally RV infected children and shown to reflect the intestinal Ig immune response. Total plasma sIga and plasma RV-sIg were evaluated by eLIsa in children with gastroenteritis due or not due to RV infection and in 50 children vaccinated with the attenuated RIX4414 human RV vaccine and 62 placebo recipients. RV-sIg was only detected in children with evidence of previous RV infection or with acute RV gastroenteritis. Vaccinees had higher RV-sIg titers than placebo recipients and RV-sIg titers increased after the second vaccine dose. RV-sIg measured after the second dose correlated with protection when vaccinees and placebo recipients were analyzed jointly. RV-sIg may serve as a valuable correlate of protection for RV vaccines.",

keywords = "Correlate of protection, Rotavirus, Secretory immunoglobulin, Vaccine",

author = "Daniel Herrera and Camilo V{\'a}squez and Blaise Corth{\'e}sy and Franco, {Manuel A.} and Juana Angel",

note = "Funding Information: This publication was financed by the Pontificia Universidad Javeriana (ID4215). We thank the subjects who participated in the previous studies for their generosity, the personnel of the Pediatrics Department of the San Ignacio Hospital for their help",

year = "2013",

month = nov,

doi = "10.4161/hv.25610",

language = "English",

volume = "9",

pages = "2409--2417",

journal = "Human Vaccines and Immunotherapeutics",

issn = "2164-5515",

publisher = "Landes Bioscience",

number = "11",

}

Rotavirus specific plasma secretory immunoglobulin in children with acute gastroenteritis and children vaccinated with an attenuated human rotavirus vaccine. / Herrera, Daniel; Vásquez, Camilo; Corthésy, Blaise et al.
En: Human Vaccines and Immunotherapeutics, Vol. 9, N.º 11, 11.2013, p. 2409-2417.

Producción: Contribución a una revista › Artículo › revisión exhaustiva

TY - JOUR

T1 - Rotavirus specific plasma secretory immunoglobulin in children with acute gastroenteritis and children vaccinated with an attenuated human rotavirus vaccine

AU - Herrera, Daniel

AU - Vásquez, Camilo

AU - Corthésy, Blaise

AU - Franco, Manuel A.

AU - Angel, Juana

N1 - Funding Information: This publication was financed by the Pontificia Universidad Javeriana (ID4215). We thank the subjects who participated in the previous studies for their generosity, the personnel of the Pediatrics Department of the San Ignacio Hospital for their help

PY - 2013/11

Y1 - 2013/11

N2 - Rotavirus (RV)-specific secretory immunoglobulin (RV-sIg) has been previously detected in serum of naturally RV infected children and shown to reflect the intestinal Ig immune response. Total plasma sIga and plasma RV-sIg were evaluated by eLIsa in children with gastroenteritis due or not due to RV infection and in 50 children vaccinated with the attenuated RIX4414 human RV vaccine and 62 placebo recipients. RV-sIg was only detected in children with evidence of previous RV infection or with acute RV gastroenteritis. Vaccinees had higher RV-sIg titers than placebo recipients and RV-sIg titers increased after the second vaccine dose. RV-sIg measured after the second dose correlated with protection when vaccinees and placebo recipients were analyzed jointly. RV-sIg may serve as a valuable correlate of protection for RV vaccines.

AB - Rotavirus (RV)-specific secretory immunoglobulin (RV-sIg) has been previously detected in serum of naturally RV infected children and shown to reflect the intestinal Ig immune response. Total plasma sIga and plasma RV-sIg were evaluated by eLIsa in children with gastroenteritis due or not due to RV infection and in 50 children vaccinated with the attenuated RIX4414 human RV vaccine and 62 placebo recipients. RV-sIg was only detected in children with evidence of previous RV infection or with acute RV gastroenteritis. Vaccinees had higher RV-sIg titers than placebo recipients and RV-sIg titers increased after the second vaccine dose. RV-sIg measured after the second dose correlated with protection when vaccinees and placebo recipients were analyzed jointly. RV-sIg may serve as a valuable correlate of protection for RV vaccines.

KW - Correlate of protection

KW - Rotavirus

KW - Secretory immunoglobulin

KW - Vaccine

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M3 - Article

C2 - 23839157

AN - SCOPUS:84887462570

SN - 2164-5515

VL - 9

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JO - Human Vaccines and Immunotherapeutics

JF - Human Vaccines and Immunotherapeutics

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ER -

Rotavirus specific plasma secretory immunoglobulin in children with acute gastroenteritis and children vaccinated with an attenuated human rotavirus vaccine

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