TY - JOUR
T1 - Risk factors characterisation for CHD
T2 - a case-control study in Bogota and Cali, Colombia, 2002-2020
AU - Portilla R, Esteban
AU - Harizanov, Vyara
AU - Sarmiento, Karen
AU - Holguín, Jorge
AU - Gracia, Gloria
AU - Hurtado-Villa, Paula
AU - Zarante, Ignacio
N1 - Publisher Copyright:
© The Author(s), 2023. Published by Cambridge University Press.
PY - 2023/6/15
Y1 - 2023/6/15
N2 - OBJECTIVE: CHDs correspond to 28% of all congenital anomalies, being the leading cause of infant mortality in the first year of life. Thus, it is essential to explore risk factors for CHDs presentation, allowing the detection of probable cases within a population. METHODS: We identified newborns with CHDs within a cohort from the Program for the Prevention and Monitoring of Congenital Defects in Bogota and Cali, 2002-2020. Cases were classified as isolated, complex isolated, polymalformed, and syndromic. Variables were analysed by comparing case and control averages with Student's t test using a 95% confidence level. RESULTS: Prevalence obtained was 19.36 per 10 000 live births; non-specified CHD, ventricular septal defect, and atrial septal defect were the most prevalent. As risk factors were found: paternal and maternal age above 45 years, pregestational diabetes, mother's body mass index above 25, low educational level, and socio-economic status. As protective factors: folic acid consumption within the first trimester and pregestational period. CONCLUSION: Different risk and protective factors associated with the presentation of CHDs have been described. We consider that public health strategies should be aimed to reduce risk factors exposure. Also, improving diagnosis and prognosis by having a close monitoring on high-risk patients.
AB - OBJECTIVE: CHDs correspond to 28% of all congenital anomalies, being the leading cause of infant mortality in the first year of life. Thus, it is essential to explore risk factors for CHDs presentation, allowing the detection of probable cases within a population. METHODS: We identified newborns with CHDs within a cohort from the Program for the Prevention and Monitoring of Congenital Defects in Bogota and Cali, 2002-2020. Cases were classified as isolated, complex isolated, polymalformed, and syndromic. Variables were analysed by comparing case and control averages with Student's t test using a 95% confidence level. RESULTS: Prevalence obtained was 19.36 per 10 000 live births; non-specified CHD, ventricular septal defect, and atrial septal defect were the most prevalent. As risk factors were found: paternal and maternal age above 45 years, pregestational diabetes, mother's body mass index above 25, low educational level, and socio-economic status. As protective factors: folic acid consumption within the first trimester and pregestational period. CONCLUSION: Different risk and protective factors associated with the presentation of CHDs have been described. We consider that public health strategies should be aimed to reduce risk factors exposure. Also, improving diagnosis and prognosis by having a close monitoring on high-risk patients.
KW - Congenital heart disease
KW - congenital anomaly
KW - public health
KW - risk factor
KW - surveillance
UR - https://www.scopus.com/pages/publications/85182955752
UR - https://www.mendeley.com/catalogue/98541aa2-2bee-3e66-9815-1abbd9c45a2d/
U2 - 10.1017/s1047951123001324
DO - 10.1017/s1047951123001324
M3 - Article
C2 - 37318127
AN - SCOPUS:85182955752
SN - 1047-9511
VL - 34
SP - 178
EP - 182
JO - Cardiology in the Young
JF - Cardiology in the Young
IS - 1
ER -
