Regulation of protective immunity against Leishmania major in mice

Jacques Louis, Hayo Himmelrich, Carlos Parra-Lopez, Fabienne Tacchini-Cottier, Pascal Launois

Producción: Contribución a una revistaArtículorevisión exhaustiva

84 Citas (Scopus)

Resumen

Resolution of lesions induced by Leishmania major in mice results from the development of Th1 responses. Cytokines produced by Th1 cells activate macrophages to a parasiticidal state. The development of Th2 responses in mice from a few strains underlies susceptibility to infection. Cytokines produced by Th2 cells exacerbate the development of lesions because of their deactivating properties for macrophages. This murine model of infection has provided significant insight into the mechanisms intrinsic to the differentiation of disparate CD4+T cell subsets in vivo in animals from different genetic backgrounds.

Idioma originalInglés
Páginas (desde-hasta)459-464
Número de páginas6
PublicaciónCurrent Opinion in Immunology
Volumen10
N.º4
DOI
EstadoPublicada - ago. 1998
Publicado de forma externa

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