TY - CHAP
T1 - Protective in vitro activity of Physalis peruviana calyces extract on oxidation and glycation
AU - Valderrama, Ivonne H.
AU - Echeverry, Sandra M.
AU - Ospina, Luis F.
AU - Costa, Geison M.
AU - Aragón, Diana M.
N1 - Publisher Copyright:
© 2024 Elsevier Inc. All rights reserved including those for text and data mining AI training and similar technologies.
PY - 2024/1/1
Y1 - 2024/1/1
N2 - Previous studies have demonstrated that Physalis peruviana has antioxidant, antiinflammatory, antidiabetic, and hepatic protective effects. The present work aimed to perform different assays to get a deeper insight into the antioxidant activity of the hydroethanolic extract of calyces from P. peruviana (HEPP) and its fractions. 2,2-Diphenyl-1-picrylhydrazyl (DPPH·) scavenging, lipid peroxidation, low-density lipoprotein cholesterol (LDL-c), and advanced products of glycation (AGEs) were measured. Results showed that the HEPP and its butanol fraction (BFPP) displayed DPPH· radical scavenging activities with IC50 values of 29.9 and 51.4µg/mL, respectively. Similar results were obtained when the diene formation was induced in LDL-c: IC50 values of 211.2 and 103.0µg/mL, for HEPP and BFPP, respectively. HEPP, BFPP and EFPP showed antiglycation activity with IC50 of 141.1, 183.0, and 226.7µg/mL, respectively. In sum, HEPP and BFPP have the potential to prevent tissues from free radicals and thereby protect the cellular membranes from lipid peroxidation.
AB - Previous studies have demonstrated that Physalis peruviana has antioxidant, antiinflammatory, antidiabetic, and hepatic protective effects. The present work aimed to perform different assays to get a deeper insight into the antioxidant activity of the hydroethanolic extract of calyces from P. peruviana (HEPP) and its fractions. 2,2-Diphenyl-1-picrylhydrazyl (DPPH·) scavenging, lipid peroxidation, low-density lipoprotein cholesterol (LDL-c), and advanced products of glycation (AGEs) were measured. Results showed that the HEPP and its butanol fraction (BFPP) displayed DPPH· radical scavenging activities with IC50 values of 29.9 and 51.4µg/mL, respectively. Similar results were obtained when the diene formation was induced in LDL-c: IC50 values of 211.2 and 103.0µg/mL, for HEPP and BFPP, respectively. HEPP, BFPP and EFPP showed antiglycation activity with IC50 of 141.1, 183.0, and 226.7µg/mL, respectively. In sum, HEPP and BFPP have the potential to prevent tissues from free radicals and thereby protect the cellular membranes from lipid peroxidation.
KW - biochemistry applications, food analysis
KW - Food products
KW - pharmaceutical chemistry
KW - pharmacological parameter
UR - http://www.scopus.com/inward/record.url?scp=85193333803&partnerID=8YFLogxK
U2 - 10.1016/B978-0-443-15433-1.00037-6
DO - 10.1016/B978-0-443-15433-1.00037-6
M3 - Chapter
AN - SCOPUS:85193333803
SN - 9780443154348
SP - 447
EP - 454
BT - Handbook of Goldenberry (Physalis peruviana)
PB - Elsevier
ER -