TY - JOUR
T1 - Prevalence and risk factors for chagas disease in pregnant women in Casanare, Colombia
AU - Cucunubá, Zulma M.
AU - Flórez, Astrid C.
AU - Cárdenas, Ángela
AU - Pavía, Paula
AU - Montilla, Marleny
AU - Aldana, Rodrigo
AU - Villamizar, Katherine
AU - Ríos, Lyda C.
AU - Nicholls, Rubén S.
AU - Puerta, Concepción J.
PY - 2012/11
Y1 - 2012/11
N2 - Knowledge of the prevalence and risk factors associated with maternal infection is the first step to develop a surveillance system for congenital transmission of Chagas disease. We conducted a cross-sectional study in Casanare, a disease-endemic area in Colombia. A total of 982 patients were enrolled in the study. A global prevalence of Trypanosoma cruzi infection of 4.0% (95% confidence interval [CI] = 2.8-5.3%) was found. Multivariate analysis showed that the most important risk-associated factors were age > 29 years (adjusted odds ratio [aOR] = 3.4, 95% CI = 0.9-12.4), rural residency (aOR = 2.2, 95% CI = 1.0-4.6), low education level (aOR = 10.2, 95% CI = 1.6-82.7), and previous knowledge of the vector (aOR = 2.2, 95% CI = 1.0-4.9). Relatives and siblings of infected mothers showed a prevalence of 9.3%. These findings may help physicians to investigate congenital cases, screen Chagas disease in siblings and relatives, and provide early treatment to prevent the chronic complications of Chagas disease.
AB - Knowledge of the prevalence and risk factors associated with maternal infection is the first step to develop a surveillance system for congenital transmission of Chagas disease. We conducted a cross-sectional study in Casanare, a disease-endemic area in Colombia. A total of 982 patients were enrolled in the study. A global prevalence of Trypanosoma cruzi infection of 4.0% (95% confidence interval [CI] = 2.8-5.3%) was found. Multivariate analysis showed that the most important risk-associated factors were age > 29 years (adjusted odds ratio [aOR] = 3.4, 95% CI = 0.9-12.4), rural residency (aOR = 2.2, 95% CI = 1.0-4.6), low education level (aOR = 10.2, 95% CI = 1.6-82.7), and previous knowledge of the vector (aOR = 2.2, 95% CI = 1.0-4.9). Relatives and siblings of infected mothers showed a prevalence of 9.3%. These findings may help physicians to investigate congenital cases, screen Chagas disease in siblings and relatives, and provide early treatment to prevent the chronic complications of Chagas disease.
UR - http://www.scopus.com/inward/record.url?scp=84869142885&partnerID=8YFLogxK
U2 - 10.4269/ajtmh.2012.12-0086
DO - 10.4269/ajtmh.2012.12-0086
M3 - Article
C2 - 23033397
AN - SCOPUS:84869142885
SN - 0002-9637
VL - 87
SP - 837
EP - 842
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 5
ER -
