Plant-derived extracts P2Et and Anamu-SC affect NO and ROS levels in leukemic cells

Título traducido de la contribución: Los extractos derivados de plantas P2Et y Anamu-SC afectan los niveles de NO y ROS en células leucémicas

Juan José Arévalo-Ferrin, Jimmy Alejandro García-Ortiz, Cindy Mayerli Arévalo-Olaya, Sandra Milena Quijano-Gómez, Susana Fiorentino-Gómez, Viviana Marcela Rodríguez-Pardo

Producción: Contribución a una revistaArtículorevisión exhaustiva

2 Citas (Scopus)

Resumen

Leukemic cells often show high nitric oxide (NO) and reactive oxygen species (ROS) levels. These can lead to resistance to apoptosis and therapy and increased proliferation. Plant-derived extracts decrease chemoresistance in cancer cells. In this study, we evaluated the effects of the plant-derived extracts P2Et (Caesalpinia spinosa) and Anamu-SC (Petiveria alliacea) and their combination with chemotherapeutic agents on NO and ROS levels in leukemic cell lines K562 and Reh. NO and ROS were determined using the DAF-FM DA and H2DCFDA probes. The mean fluorescence intensity for each variable was measured by flow cytometry. The extracts showed an antioxidant effect on both cell lines leading to a significant decrease in ROS levels without decreasing cell viability. Anamu-SC also increased NO levels in K562 cells when combined with idarubicin. Both extracts reduced the number of leukemic cells after 12 hours of treatment. Further studies are necessary to evaluate their effect on primary human leukemia cells. These findings suggest the potential of P2Et and Anamu-SC as adjuncts in leukemia treatment.

Título traducido de la contribuciónLos extractos derivados de plantas P2Et y Anamu-SC afectan los niveles de NO y ROS en células leucémicas
Idioma originalInglés
Páginas (desde-hasta)201-216
Número de páginas16
PublicaciónUniversitas Scientiarum
Volumen28
N.º2
DOI
EstadoPublicada - 2023

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