TY - JOUR
T1 - Plant-derived extracts and metabolic modulation in leukemia
T2 - a promising approach to overcome treatment resistance
AU - Arévalo, Cindy Mayerli
AU - Cruz-Rodriguez, Nataly
AU - Quijano, Sandra
AU - Fiorentino, Susana
N1 - Publisher Copyright:
Copyright © 2023 Arévalo, Cruz-Rodriguez, Quijano and Fiorentino.
PY - 2023
Y1 - 2023
N2 - Leukemic cells acquire complex and often multifactorial mechanisms of resistance to treatment, including various metabolic alterations. Although the use of metabolic modulators has been proposed for several decades, their use in clinical practice has not been established. Natural products, the so-called botanical drugs, are capable of regulating tumor metabolism, particularly in hematopoietic tumors, which could partly explain the biological activity attributed to them for a long time. This review addresses the most recent findings relating to metabolic reprogramming—Mainly in the glycolytic pathway and mitochondrial activity—Of leukemic cells and its role in the generation of resistance to conventional treatments, the modulation of the tumor microenvironment, and the evasion of immune response. In turn, it describes how the modulation of metabolism by plant-derived extracts can counteract resistance to chemotherapy in this tumor model and contribute to the activation of the antitumor immune system.
AB - Leukemic cells acquire complex and often multifactorial mechanisms of resistance to treatment, including various metabolic alterations. Although the use of metabolic modulators has been proposed for several decades, their use in clinical practice has not been established. Natural products, the so-called botanical drugs, are capable of regulating tumor metabolism, particularly in hematopoietic tumors, which could partly explain the biological activity attributed to them for a long time. This review addresses the most recent findings relating to metabolic reprogramming—Mainly in the glycolytic pathway and mitochondrial activity—Of leukemic cells and its role in the generation of resistance to conventional treatments, the modulation of the tumor microenvironment, and the evasion of immune response. In turn, it describes how the modulation of metabolism by plant-derived extracts can counteract resistance to chemotherapy in this tumor model and contribute to the activation of the antitumor immune system.
KW - acute leukemias
KW - botanical drugs
KW - metabolism
KW - natural products
KW - resistance
UR - http://www.scopus.com/inward/record.url?scp=85165962155&partnerID=8YFLogxK
U2 - 10.3389/fmolb.2023.1229760
DO - 10.3389/fmolb.2023.1229760
M3 - Review article
AN - SCOPUS:85165962155
SN - 2296-889X
VL - 10
JO - Frontiers in Molecular Biosciences
JF - Frontiers in Molecular Biosciences
M1 - 1229760
ER -