Plant-derived extracts and metabolic modulation in leukemia: a promising approach to overcome treatment resistance

Cindy Mayerli Arévalo, Nataly Cruz-Rodriguez, Sandra Quijano, Susana Fiorentino

Producción: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

2 Citas (Scopus)

Resumen

Leukemic cells acquire complex and often multifactorial mechanisms of resistance to treatment, including various metabolic alterations. Although the use of metabolic modulators has been proposed for several decades, their use in clinical practice has not been established. Natural products, the so-called botanical drugs, are capable of regulating tumor metabolism, particularly in hematopoietic tumors, which could partly explain the biological activity attributed to them for a long time. This review addresses the most recent findings relating to metabolic reprogramming—Mainly in the glycolytic pathway and mitochondrial activity—Of leukemic cells and its role in the generation of resistance to conventional treatments, the modulation of the tumor microenvironment, and the evasion of immune response. In turn, it describes how the modulation of metabolism by plant-derived extracts can counteract resistance to chemotherapy in this tumor model and contribute to the activation of the antitumor immune system.

Idioma originalInglés
Número de artículo1229760
PublicaciónFrontiers in Molecular Biosciences
Volumen10
DOI
EstadoPublicada - 2023

Huella

Profundice en los temas de investigación de 'Plant-derived extracts and metabolic modulation in leukemia: a promising approach to overcome treatment resistance'. En conjunto forman una huella única.

Citar esto