TY - GEN
T1 - Interrelationship between broadband NIRS measurements of cerebral cytochrome C oxidase and systemic changes indicates injury severity in neonatal encephalopathy
AU - Bale, Gemma
AU - Mitra, Subhabrata
AU - de Roever, Isabel
AU - Chan, Marcus
AU - Caicedo-Dorado, Alexander
AU - Meek, Judith
AU - Robertson, Nicola
AU - Tachtsidis, Ilias
N1 - Publisher Copyright:
© Springer International Publishing Switzerland 2016.
PY - 2016
Y1 - 2016
N2 - Perinatal hypoxic ischaemic encephalopathy (HIE) is associated with severe neurodevelopmental problems and mortality. There is a clinical need for techniques to provide cotside assessment of the injury extent. This study aims to use non-invasive cerebral broadband near-infrared spectroscopy (NIRS) in combination with systemic physiology to assess the severity of HIE injury. Broadband NIRS is used to measure the changes in haemodynamics, oxygenation and the oxidation state of cytochrome c oxidase (oxCCO). We used canonical correlation analysis (CCA), a multivariate statistical technique, to measure the relationship between cerebral broadband NIRS measurements and systemic physiology. A strong relationship between the metabolic marker, oxCCO, and systemic changes indicated severe brain injury; if more than 60 % of the oxCCO signal could be explained by the systemic variations, then the neurodevelopmental outcome was poor. This boundary has high sensitivity and specifi city (100 and 83 %, respectively). Broadband NIRS measured concentration changes of the oxidation state of cytochrome c oxidase has the potential to become a useful cotside tool for assessment of injury severity following hypoxic ischaemic brain injury.
AB - Perinatal hypoxic ischaemic encephalopathy (HIE) is associated with severe neurodevelopmental problems and mortality. There is a clinical need for techniques to provide cotside assessment of the injury extent. This study aims to use non-invasive cerebral broadband near-infrared spectroscopy (NIRS) in combination with systemic physiology to assess the severity of HIE injury. Broadband NIRS is used to measure the changes in haemodynamics, oxygenation and the oxidation state of cytochrome c oxidase (oxCCO). We used canonical correlation analysis (CCA), a multivariate statistical technique, to measure the relationship between cerebral broadband NIRS measurements and systemic physiology. A strong relationship between the metabolic marker, oxCCO, and systemic changes indicated severe brain injury; if more than 60 % of the oxCCO signal could be explained by the systemic variations, then the neurodevelopmental outcome was poor. This boundary has high sensitivity and specifi city (100 and 83 %, respectively). Broadband NIRS measured concentration changes of the oxidation state of cytochrome c oxidase has the potential to become a useful cotside tool for assessment of injury severity following hypoxic ischaemic brain injury.
KW - Cytochrome c oxidase
KW - Hypoxic ischaemic encephalopathy
KW - Near-infrared spectroscopy
KW - Neonatal
KW - Oxygen metabolism
UR - http://www.scopus.com/inward/record.url?scp=84984801078&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-38810-6_24
DO - 10.1007/978-3-319-38810-6_24
M3 - Conference contribution
C2 - 27526141
AN - SCOPUS:84984801078
SN - 9783319388083
T3 - Advances in Experimental Medicine and Biology
SP - 181
EP - 186
BT - Oxygen Transport to Tissue XXXVIII
A2 - Bruley, Duane F.
A2 - Luo, Qingming
A2 - Li, Lin Z.
A2 - Shi, Hua
A2 - Harrison, David K.
A2 - Bruley, Duane F.
PB - Springer New York LLC
T2 - 43rd Annual Meeting of the International Society on Oxygen Transport to Tissue, ISOTT 2015
Y2 - 11 July 2015 through 16 July 2015
ER -