Inestabilidad microsatelital y cáncer gástrico

Gabriela Negrete-Tobar; Alejandro González-Motta; Oscar Alberto Messa-Botero; Juan Carlos Galvis; Isabella Garciandía-Rozo; Juan Sebastián Álvarez-Martínez; Juliana Pineda-Ortega; Natalia Londoño de Vivero; Ricardo Bruges-Maya

doi:10.30944/20117582.658

Inestabilidad microsatelital y cáncer gástrico

Gabriela Negrete-Tobar, Alejandro González-Motta, Oscar Alberto Messa-Botero, Juan Carlos Galvis, Isabella Garciandía-Rozo, Juan Sebastián Álvarez-Martínez, Juliana Pineda-Ortega, Natalia Londoño de Vivero, Ricardo Bruges-Maya

Producción: Contribución a una revista › Artículo › revisión exhaustiva

Resumen

Microsatellite instability is caused by an alteration of the mismatch repair systems, which can affect microsatellites within the entire human genome, causing errors in their replication. Published studies, mainly in the English literature, have found that some tumors, such as gastric ones, can express microsatellite instability. In this review, a description of the mismatch repair systems and their relationship with the presence of microsatellite instability in gastric tumors is presented, as well as its possible clinical utility, as an associated factor in the response to immunotherapy treatment, in patients with gastric cancer.

Título traducido de la contribución	Microsatellite instability and gastric cancer
Idioma original	Español
Páginas (desde-hasta)	120-131
Número de páginas	12
Publicación	Revista Colombiana de Cirugia
Volumen	36
N.º	1
DOI	https://doi.org/10.30944/20117582.658
Estado	Publicada - 2021

Palabras clave

Cancer; gastric; microsatellite instability
Immunotherapy
Treatment

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title = "Inestabilidad microsatelital y c{\'a}ncer g{\'a}strico",

abstract = "Microsatellite instability is caused by an alteration of the mismatch repair systems, which can affect microsatellites within the entire human genome, causing errors in their replication. Published studies, mainly in the English literature, have found that some tumors, such as gastric ones, can express microsatellite instability. In this review, a description of the mismatch repair systems and their relationship with the presence of microsatellite instability in gastric tumors is presented, as well as its possible clinical utility, as an associated factor in the response to immunotherapy treatment, in patients with gastric cancer.",

keywords = "Cancer; gastric; microsatellite instability, Immunotherapy, Treatment",

author = "Gabriela Negrete-Tobar and Alejandro Gonz{\'a}lez-Motta and Messa-Botero, {Oscar Alberto} and Galvis, {Juan Carlos} and Isabella Garciand{\'i}a-Rozo and {\'A}lvarez-Mart{\'i}nez, {Juan Sebasti{\'a}n} and Juliana Pineda-Ortega and {de Vivero}, {Natalia Londo{\~n}o} and Ricardo Bruges-Maya",

year = "2021",

doi = "10.30944/20117582.658",

language = "Espa{\~n}ol ",

volume = "36",

pages = "120--131",

journal = "Revista Colombiana de Cirugia",

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AU - Negrete-Tobar, Gabriela

AU - González-Motta, Alejandro

AU - Messa-Botero, Oscar Alberto

AU - Galvis, Juan Carlos

AU - Garciandía-Rozo, Isabella

AU - Álvarez-Martínez, Juan Sebastián

AU - Pineda-Ortega, Juliana

AU - de Vivero, Natalia Londoño

AU - Bruges-Maya, Ricardo

PY - 2021

Y1 - 2021

N2 - Microsatellite instability is caused by an alteration of the mismatch repair systems, which can affect microsatellites within the entire human genome, causing errors in their replication. Published studies, mainly in the English literature, have found that some tumors, such as gastric ones, can express microsatellite instability. In this review, a description of the mismatch repair systems and their relationship with the presence of microsatellite instability in gastric tumors is presented, as well as its possible clinical utility, as an associated factor in the response to immunotherapy treatment, in patients with gastric cancer.

AB - Microsatellite instability is caused by an alteration of the mismatch repair systems, which can affect microsatellites within the entire human genome, causing errors in their replication. Published studies, mainly in the English literature, have found that some tumors, such as gastric ones, can express microsatellite instability. In this review, a description of the mismatch repair systems and their relationship with the presence of microsatellite instability in gastric tumors is presented, as well as its possible clinical utility, as an associated factor in the response to immunotherapy treatment, in patients with gastric cancer.

KW - Cancer; gastric; microsatellite instability

KW - Immunotherapy

KW - Treatment

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DO - 10.30944/20117582.658

M3 - Artículo

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JO - Revista Colombiana de Cirugia

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ER -

Inestabilidad microsatelital y cáncer gástrico

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