Impact of vaccination in the mortality of colombian adults with acute respiratory distress syndrome due to SARS-CoV-2 who required invasive mechanical ventilation

Yina Daniela Benítez Patiño; Luis Carlos Triana; Oscar Mauricio Muñoz Velandia; Viviana Yiset López Ramírez; Laura María Niño Guerra; Santiago Bottia Córdoba

doi:10.1016/j.vacun.2023.07.004

Impact of vaccination in the mortality of colombian adults with acute respiratory distress syndrome due to SARS-CoV-2 who required invasive mechanical ventilation

Título traducido de la contribución: Impacto de la vacunación en la mortalidad de adultos colombianos con síndrome de dificultad respiratoria aguda por SARS-CoV-2 que requirieron ventilación mecánica invasiva

Yina Daniela Benítez Patiño, Luis Carlos Triana, Oscar Mauricio Muñoz Velandia, Viviana Yiset López Ramírez, Laura María Niño Guerra, Santiago Bottia Córdoba

Universidad Javeriana

Producción: Contribución a una revista › Artículo › revisión exhaustiva

Resumen

Introducción
la vacunación para SARS-CoV-2 permitió disminuir casos graves que requieren de ventilación mecánica invasiva (VMI) y atención en UCI. Sin embargo, no es claro su impacto en la enfermedad grave. El objetivo fue evaluar si los adultos con neumonía grave por SARS-CoV-2 que requirieron ventilación mecánica tuvieron un comportamiento clínico diferente en términos de mortalidad, según su estado de vacunación.

Metodología
estudio de cohorte retrospectiva, en adultos con neumonía severa por SARS-CoV-2 con requerimiento de VMI y UCI. Se evaluaron desenlaces clínicos según el estado de vacunación, controlando por comorbilidades.

Resultados
Se analizaron 200 pacientes (24% vacunados, edad 61 ± 13 años, hombres 68%). Los vacunados tenían menor PCR al ingreso, presión de distensión y requerimiento de PEEP para VMI. La mortalidad (43,8 vs. 36,8%, p: 0,335), la estancia hospitalaria, la estancia en UCI y el tiempo en VMI fueron similares entre los grupos. La lesión renal aguda y el requerimiento de hemodiálisis (0 vs. 9,2%, p: 0,03) fueron más frecuentes en los no vacunados. No hubo asociación entre la mortalidad y recibir al menos una dosis de vacunación (RR 1,21; IC 95% 0,829–1,774, p: 0,334).

Conclusiones
la vacunación no impactó la mortalidad; sin embargo, nuestros datos sugieren que puede reducir el estado de inflamación producido por la enfermedad y la aparición de lesión renal aguda y el requerimiento de hemodiálisis. Se requerirán estudios futuros para evaluar el impacto del tipo de vacuna y/o el número de dosis recibidas.

Título traducido de la contribución	Impacto de la vacunación en la mortalidad de adultos colombianos con síndrome de dificultad respiratoria aguda por SARS-CoV-2 que requirieron ventilación mecánica invasiva
Idioma original	Inglés
Páginas (desde-hasta)	335-340
Número de páginas	6
Publicación	Vacunas
Volumen	24
N.º	4
DOI	https://doi.org/10.1016/j.vacun.2023.07.004
Estado	Publicada - 01 oct. 2023

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Acceder al documento

10.1016/j.vacun.2023.07.004

Otros archivos y enlaces

Citar esto

Benítez Patiño, Y. D., Triana, L. C., Muñoz Velandia, O. M., López Ramírez, V. Y., Niño Guerra, L. M., & Bottia Córdoba, S. (2023). Impact of vaccination in the mortality of colombian adults with acute respiratory distress syndrome due to SARS-CoV-2 who required invasive mechanical ventilation. Vacunas, 24(4), 335-340. https://doi.org/10.1016/j.vacun.2023.07.004

@article{c6656aa508b645dc856ad69a98a0da1a,

title = "Impact of vaccination in the mortality of colombian adults with acute respiratory distress syndrome due to SARS-CoV-2 who required invasive mechanical ventilation",

abstract = "Introduction: Vaccination for SARS-CoV-2 made it possible to reduce severe cases that require invasive mechanical ventilation (IMV) and care in the ICU. However, its impact on severe disease is not clear. The objective was to assess whether adults with severe SARS-CoV-2 pneumonia who required mechanical ventilation had a different clinical behavior in terms of mortality, depending on their vaccination status. Methodology: Retrospective cohort study, in adults with severe pneumonia due to SARS-CoV-2 requiring IMV and ICU. Clinical outcomes were evaluated according to vaccination status, controlling for comorbidities. Results: Two hundred patients (24% vaccinated, age 61 ± 13 years, men 68%) were analyzed. The vaccinated had lower CRP at admission, distension pressure and PEEP requirement for IMV. Mortality (43.8 vs 36.8%, p: 0.335), hospital stay, ICU stay, and time on IMV were similar between groups. Acute kidney injury and hemodialysis requirement (0 vs 9.2%, p: 0.03) were more frequent in the unvaccinated. There was no association between mortality and receiving at least one dose of vaccination (RR 1.21; CI 95% 0.829–1.774, p: 0.335). Conclusions: Vaccination did not impact mortality. However, our data suggest that it may reduce the inflammatory state produced by the disease and the occurrence of acute kidney injury and the requirement for hemodialysis. Future studies will be required to assess the impact of the type of vaccine and/or the number of doses received.",

keywords = "Artificial Respiration, Coronavirus Infections, Critical Care, Vaccination",

author = "{Ben{\'i}tez Pati{\~n}o}, {Yina Daniela} and Triana, {Luis Carlos} and {Mu{\~n}oz Velandia}, {Oscar Mauricio} and {L{\'o}pez Ram{\'i}rez}, {Viviana Yiset} and {Ni{\~n}o Guerra}, {Laura Mar{\'i}a} and {Bottia C{\'o}rdoba}, Santiago",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Espa{\~n}a, S.L.U.",

year = "2023",

month = oct,

day = "1",

doi = "10.1016/j.vacun.2023.07.004",

language = "English",

volume = "24",

pages = "335--340",

journal = "Vacunas",

issn = "1576-9887",

publisher = "Ediciones Doyma, S.L.",

number = "4",

}

Impact of vaccination in the mortality of colombian adults with acute respiratory distress syndrome due to SARS-CoV-2 who required invasive mechanical ventilation. / Benítez Patiño, Yina Daniela; Triana, Luis Carlos ; Muñoz Velandia, Oscar Mauricio et al.
En: Vacunas, Vol. 24, N.º 4, 01.10.2023, p. 335-340.

Producción: Contribución a una revista › Artículo › revisión exhaustiva

TY - JOUR

T1 - Impact of vaccination in the mortality of colombian adults with acute respiratory distress syndrome due to SARS-CoV-2 who required invasive mechanical ventilation

AU - Benítez Patiño, Yina Daniela

AU - Triana, Luis Carlos

AU - Muñoz Velandia, Oscar Mauricio

AU - López Ramírez, Viviana Yiset

AU - Niño Guerra, Laura María

AU - Bottia Córdoba, Santiago

PY - 2023/10/1

Y1 - 2023/10/1

N2 - Introduction: Vaccination for SARS-CoV-2 made it possible to reduce severe cases that require invasive mechanical ventilation (IMV) and care in the ICU. However, its impact on severe disease is not clear. The objective was to assess whether adults with severe SARS-CoV-2 pneumonia who required mechanical ventilation had a different clinical behavior in terms of mortality, depending on their vaccination status. Methodology: Retrospective cohort study, in adults with severe pneumonia due to SARS-CoV-2 requiring IMV and ICU. Clinical outcomes were evaluated according to vaccination status, controlling for comorbidities. Results: Two hundred patients (24% vaccinated, age 61 ± 13 years, men 68%) were analyzed. The vaccinated had lower CRP at admission, distension pressure and PEEP requirement for IMV. Mortality (43.8 vs 36.8%, p: 0.335), hospital stay, ICU stay, and time on IMV were similar between groups. Acute kidney injury and hemodialysis requirement (0 vs 9.2%, p: 0.03) were more frequent in the unvaccinated. There was no association between mortality and receiving at least one dose of vaccination (RR 1.21; CI 95% 0.829–1.774, p: 0.335). Conclusions: Vaccination did not impact mortality. However, our data suggest that it may reduce the inflammatory state produced by the disease and the occurrence of acute kidney injury and the requirement for hemodialysis. Future studies will be required to assess the impact of the type of vaccine and/or the number of doses received.

AB - Introduction: Vaccination for SARS-CoV-2 made it possible to reduce severe cases that require invasive mechanical ventilation (IMV) and care in the ICU. However, its impact on severe disease is not clear. The objective was to assess whether adults with severe SARS-CoV-2 pneumonia who required mechanical ventilation had a different clinical behavior in terms of mortality, depending on their vaccination status. Methodology: Retrospective cohort study, in adults with severe pneumonia due to SARS-CoV-2 requiring IMV and ICU. Clinical outcomes were evaluated according to vaccination status, controlling for comorbidities. Results: Two hundred patients (24% vaccinated, age 61 ± 13 years, men 68%) were analyzed. The vaccinated had lower CRP at admission, distension pressure and PEEP requirement for IMV. Mortality (43.8 vs 36.8%, p: 0.335), hospital stay, ICU stay, and time on IMV were similar between groups. Acute kidney injury and hemodialysis requirement (0 vs 9.2%, p: 0.03) were more frequent in the unvaccinated. There was no association between mortality and receiving at least one dose of vaccination (RR 1.21; CI 95% 0.829–1.774, p: 0.335). Conclusions: Vaccination did not impact mortality. However, our data suggest that it may reduce the inflammatory state produced by the disease and the occurrence of acute kidney injury and the requirement for hemodialysis. Future studies will be required to assess the impact of the type of vaccine and/or the number of doses received.

KW - Artificial Respiration

KW - Coronavirus Infections

KW - Critical Care

KW - Vaccination

UR - http://www.scopus.com/inward/record.url?scp=85173133991&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/6f08770e-ed2a-35e8-a1e5-8cf2587102b0/

U2 - 10.1016/j.vacun.2023.07.004

DO - 10.1016/j.vacun.2023.07.004

M3 - Article

AN - SCOPUS:85173133991

SN - 1576-9887

VL - 24

SP - 335

EP - 340

JO - Vacunas

JF - Vacunas

IS - 4

ER -

Impact of vaccination in the mortality of colombian adults with acute respiratory distress syndrome due to SARS-CoV-2 who required invasive mechanical ventilation

Resumen

ODS de las Naciones Unidas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto