Acquired hemophilia in an elderly person

Sandra Milena Castelblanco; Diego Andres Chavarro Carvajal

doi:10.36104/amc.2019.1207

Acquired hemophilia in an elderly person

Título traducido de la contribución: Hemofilia adquirida en un anciano: Reporte de caso

Sandra Milena Castelblanco, Diego Andres Chavarro Carvajal

Producción: Contribución a una revista › Artículo › revisión exhaustiva

Resumen

La hemofilia adquirida es un trastorno hemostásico poco frecuente pero altamente fatal que se presenta predominantemente en personas ancianas. Es un trastorno secundario al desarrollo de autoanticuerpos específicos dirigidos contra el factor de coagulación VIII. Se caracterizan por debutar hemorragias potencialmente fatales a nivel gastrointestinal, pulmonar, retroperitoneal, de tejidos blandos o intracraneal, por lo que requiere diagnósticos tempranos y tratamientos eficaces para su tratamiento. El presente caso es de un hombre de 78 años con hemorragia gastrointestinal asociado a equimosis y hematomas de aparición súbita en tejidos blandos y como complicación presenta hematoma laríngeo, con tiempo parcial de protrombina (PTT) prolongado, niveles de factor VIII elevados y niveles de inhibidor de factor VIII elevados.

Título traducido de la contribución	Hemofilia adquirida en un anciano: Reporte de caso
Idioma original	Inglés
Páginas (desde-hasta)	30-33
Publicación	Acta Médica Colombiana
Volumen	44
N.º	3
DOI	https://doi.org/10.36104/amc.2019.1207 https://doi.org/10.36104/amc.2019.1207
Estado	Publicada - sep. 2019

Palabras clave

hemofilia adquirida
factor VII
inhibidor
coagulopatía

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title = "Acquired hemophilia in an elderly person",

abstract = "Acquired hemophilia is a rare but highly fatal hemostatic disorder that occurs predominantly in elderly people. It is a disorder secondary to the development of specific autoantibodies directed against coagulation factor VIII. It is characterized by potentially fatal gastrointestinal, pulmonary, retroperitoneal, soft tissue or intracranial hemorrhages, so it requires early diagnoses and effective treatments. The present case is of a 78-year-old man with sudden onset gastrointestinal hemorrhage associated with ecchymosis and hematomas in soft tissues, with the complication of a laryngeal hematoma. He had a prolonged partial thromboplastin time (PTT), elevated factor VIII levels and elevated factor VIII inhibitorst. (Acta Med Colomb 2019; 44. DOI:org.siir.client.entities.ExtLink@5228f9).",

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author = "Castelblanco, {Sandra Milena} and {Chavarro Carvajal}, {Diego Andres}",

year = "2019",

month = sep,

doi = "10.36104/amc.2019.1207",

language = "English",

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T1 - Acquired hemophilia in an elderly person

AU - Castelblanco, Sandra Milena

AU - Chavarro Carvajal, Diego Andres

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AB - Acquired hemophilia is a rare but highly fatal hemostatic disorder that occurs predominantly in elderly people. It is a disorder secondary to the development of specific autoantibodies directed against coagulation factor VIII. It is characterized by potentially fatal gastrointestinal, pulmonary, retroperitoneal, soft tissue or intracranial hemorrhages, so it requires early diagnoses and effective treatments. The present case is of a 78-year-old man with sudden onset gastrointestinal hemorrhage associated with ecchymosis and hematomas in soft tissues, with the complication of a laryngeal hematoma. He had a prolonged partial thromboplastin time (PTT), elevated factor VIII levels and elevated factor VIII inhibitorst. (Acta Med Colomb 2019; 44. DOI:org.siir.client.entities.ExtLink@5228f9).

KW - hemofilia adquirida

KW - factor VII

KW - inhibidor

KW - coagulopatía

KW - acquired hemophilia

KW - factor VIII

KW - inhibitor

KW - coagulopathy

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DO - 10.36104/amc.2019.1207

M3 - Article

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JO - Acta Médica Colombiana

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Acquired hemophilia in an elderly person

Resumen

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