TY - JOUR
T1 - Gallbladder cancer in the Netherlands
T2 - Incidence, treatment and survival patterns since 1989
AU - Witjes, Caroline D.M.
AU - Van Den Akker, Sanne A.W.
AU - Visser, Otto
AU - Karim-Kos, Henrike E.
AU - De Vries, Esther
AU - Ijzermans, Jan N.M.
AU - De Man, Robert A.
AU - Coebergh, Jan Willem W.
AU - Verhoef, Cornelis
PY - 2012/6
Y1 - 2012/6
N2 - Background: To examine recent trends in gallbladder cancer (GBC) in the general population in the Western world, cancer registration data on GBC in the Netherlands were analyzed. Methods: Trends in incidence, treatment and survival, according to gender, age and stage of disease, between 1989 and 2008 for 3,917 patients were studied. Rates were age-standardized to the European standard population (European Standardized Rates - ESR). Results: The incidence rate for GBC in the Netherlands decreased rapidly during the period of 1989-2008, except for males younger than 60 years. Overall survival remained stable, short-term (3-month) and long-term (5-year) relative survival among surgically treated patients increased significantly. Treatment patterns for GBC changed. Surgery decreased from 55% in 1989 to 38% in 2008 (p < 0.001). Chemotherapy and/or irradiation increased from 1.0 to 5.8% (p < 0.001). Receiving best supportive care increased from 44% in 1989 to 57% in 2008 (p < 0.001). Conclusion: The incidence rate for GBC in the Netherlands has decreased rapidly. Treatment patterns for GBC have changed and survival among surgically treated patients has increased.
AB - Background: To examine recent trends in gallbladder cancer (GBC) in the general population in the Western world, cancer registration data on GBC in the Netherlands were analyzed. Methods: Trends in incidence, treatment and survival, according to gender, age and stage of disease, between 1989 and 2008 for 3,917 patients were studied. Rates were age-standardized to the European standard population (European Standardized Rates - ESR). Results: The incidence rate for GBC in the Netherlands decreased rapidly during the period of 1989-2008, except for males younger than 60 years. Overall survival remained stable, short-term (3-month) and long-term (5-year) relative survival among surgically treated patients increased significantly. Treatment patterns for GBC changed. Surgery decreased from 55% in 1989 to 38% in 2008 (p < 0.001). Chemotherapy and/or irradiation increased from 1.0 to 5.8% (p < 0.001). Receiving best supportive care increased from 44% in 1989 to 57% in 2008 (p < 0.001). Conclusion: The incidence rate for GBC in the Netherlands has decreased rapidly. Treatment patterns for GBC have changed and survival among surgically treated patients has increased.
KW - Gallbladder cancer
KW - Gallbladder cancer, incidence
KW - Gallbladder cancer, survival
KW - Gallbladder cancer, treatment
KW - Gallbladder cancer, trends
UR - http://www.scopus.com/inward/record.url?scp=84858726261&partnerID=8YFLogxK
U2 - 10.1159/000336217
DO - 10.1159/000336217
M3 - Article
C2 - 22441693
AN - SCOPUS:84858726261
SN - 0253-4886
VL - 29
SP - 92
EP - 98
JO - Digestive Surgery
JF - Digestive Surgery
IS - 2
ER -
