Fetal vascular malperfusion, clinicopathological correspondence in the HUSI. Bogotá, Colombia

Objectives: MVF is a recently described entity (2016), of heterogeneous histology, with high impact fetal and neonatal repercussions (IUGR, low APGAR, death, and neurological impairment). The purpose of this observational, descriptive, cross-sectional study is to evaluate the association between the clinicopathological findings of MVF and the clinical status of HUSI newborns.
Methods: For which the umbilical cords at risk (abnormal coils, abnormal insertions, and cord accidents) were characterized, along with other macroscopic alterations of interest. And then perform a complete histological diagnosis. We then compared them with the clinical outcomes obtained from the perinatal history.
Results: we can affirm that 78.5% of the placentas evaluated present some findings of MVF; the most frequent are: 51% obliteration, 43% stasis, 32% intravascular fibrin deposits, 26% ectasia, 23% thrombosis, 14% avascular villi, 10% recanalization and 2% karyorrhexis. Preliminary statistical analyzes highlight important risk factors for presenting MVF, such as chronic arterial hypertension prior to pregnancy (OR: 4.34), overweight and obesity (OR: 1.98), and the presence of concomitant MVM (OR: 2.3). Moreover the presence of MVF predisposes to the development of IUGR with an OR of 2.55. Multivariate statistical analyzes are currently in progress.
Conclusion: MVF is associated with chronic arterial hypertension prior to pregnancy, overweight and obesity, and the presence of concomitant MVM