Resumen
Objectives and Study
Most gut-microbiota studies are focused on dietary influences on microorganism composition but high inter-individualvariability that limits results interpretation and clinical relevance. We conducted a
cross-sectional descriptive study
tounderstand the influence of feeding mode on metabolites related to gut-microbiota metabolic activity.
Methods
33 healthy term-infants (birth weight>2500g) after applying inclusion/exclusion criteria (Figure1) were recruited at one-monthof age. Infant feeding was recorded using 24h recall (consumption was estimated based on the feedings/day and preparationreferred by the caregiver), anthropometry measurements (expressed as SD scores using WHO-2006 growth standard data), urineand fecal samples were obtained for the metabolic analysis of short/medium/long chain organic acid analysis through gaschromatography/mass spectrometry. Infants were grouped as group A (GA: exclusive and predominantly breastfed), and groupB (GB: partial breastfed infants).
figure1_espghan.png
enlarge
Results
From 60 infants contacted 33 infants (19 (57.6%) in GA and 14 (42.4%) in GB) were eligible for urinary metabolomics and eightfor paired urinary and fecal analysis. There were no significant differences in sex, neonatal and socio-demographic variables.Mean breast milk intake was 402.2mL(±94.9) in GA versus 307.1mL(±178.9) in GB. There was no significant difference inWeight/Length 0.05(±0.9SD) in GA versus GB -0.12(±1.2SD). Length/Age was significantly higher in GA 0.1(±0.9SD) versus GB-0.87(±0.9 SD), (P=0.004). Significant higher intakes of all quantified nutrients were observed in GB. Urinary profile (83metabolites) included 14 gut-microbiota metabolites from which seven were more frequent in GB. Fecal metabolic profile (90metabolites) showed differences in 15 metabolites between groups (sterols and medium and long fatty acids).
Conclusions
Feeding mode in the first month might influence microbiota metabolites in urine, and growth as Length/Age. These resultshighlight the need for further evaluation of feeding mode effect on gut-microbiota in a larger sample including longer follow-up.
Most gut-microbiota studies are focused on dietary influences on microorganism composition but high inter-individualvariability that limits results interpretation and clinical relevance. We conducted a
cross-sectional descriptive study
tounderstand the influence of feeding mode on metabolites related to gut-microbiota metabolic activity.
Methods
33 healthy term-infants (birth weight>2500g) after applying inclusion/exclusion criteria (Figure1) were recruited at one-monthof age. Infant feeding was recorded using 24h recall (consumption was estimated based on the feedings/day and preparationreferred by the caregiver), anthropometry measurements (expressed as SD scores using WHO-2006 growth standard data), urineand fecal samples were obtained for the metabolic analysis of short/medium/long chain organic acid analysis through gaschromatography/mass spectrometry. Infants were grouped as group A (GA: exclusive and predominantly breastfed), and groupB (GB: partial breastfed infants).
figure1_espghan.png
enlarge
Results
From 60 infants contacted 33 infants (19 (57.6%) in GA and 14 (42.4%) in GB) were eligible for urinary metabolomics and eightfor paired urinary and fecal analysis. There were no significant differences in sex, neonatal and socio-demographic variables.Mean breast milk intake was 402.2mL(±94.9) in GA versus 307.1mL(±178.9) in GB. There was no significant difference inWeight/Length 0.05(±0.9SD) in GA versus GB -0.12(±1.2SD). Length/Age was significantly higher in GA 0.1(±0.9SD) versus GB-0.87(±0.9 SD), (P=0.004). Significant higher intakes of all quantified nutrients were observed in GB. Urinary profile (83metabolites) included 14 gut-microbiota metabolites from which seven were more frequent in GB. Fecal metabolic profile (90metabolites) showed differences in 15 metabolites between groups (sterols and medium and long fatty acids).
Conclusions
Feeding mode in the first month might influence microbiota metabolites in urine, and growth as Length/Age. These resultshighlight the need for further evaluation of feeding mode effect on gut-microbiota in a larger sample including longer follow-up.
| Idioma original | Inglés |
|---|---|
| Número de páginas | 1 |
| DOI | |
| Estado | Publicada - 18 may. 2024 |
| Evento | 56th Annual Meeting of European Society for Paediatric Gastroenterologya, Hepatology and Nutrition - Milan, Italia Duración: 15 may. 2024 → 18 may. 2024 Número de conferencia: 56 |
Otros
| Otros | 56th Annual Meeting of European Society for Paediatric Gastroenterologya, Hepatology and Nutrition |
|---|---|
| Título abreviado | ESPGHAN |
| País/Territorio | Italia |
| Ciudad | Milan |
| Período | 15/05/24 → 18/05/24 |
Palabras clave
- Infants
- Microbiota
- crecimiento
- modo de alimentación
- metabolismo
ODS de las Naciones Unidas
Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible
