Failure of high-dose daptomycin for bacteremia caused by daptomycin-susceptible enterococcus faecium harboring liasr substitutions

Jose M. Munita; Nagendra N. Mishra; Danya Alvarez; Truc T. Tran; Lorena Diaz; Diana Panesso; Jinnethe Reyes; Barbara E. Murray; Javier A. Adachi; Arnold S. Bayer; Cesar A. Arias

doi:10.1093/cid/ciu642

Failure of high-dose daptomycin for bacteremia caused by daptomycin-susceptible enterococcus faecium harboring liasr substitutions

Jose M. Munita, Nagendra N. Mishra, Danya Alvarez, Truc T. Tran, Lorena Diaz, Diana Panesso, Jinnethe Reyes, Barbara E. Murray, Javier A. Adachi, Arnold S. Bayer, Cesar A. Arias

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55 Citas (Scopus)

Resumen

High-dose daptomycin (DAP) therapy failed in a neutropenic patient with bloodstream infection caused by a DAP-susceptible Enterococcus faecium (minimum inhibitory concentration, 3 μg/mL) harboring genetic changes associated with DAP resistance, with persistent bacteremia and selection of additional resistances. Daptomycin monotherapy should be used cautiously against DAP-susceptible E. faecium strains with minimum inhibitory concentrations 2 g/mL.

Idioma original	Inglés
Páginas (desde-hasta)	1277-1280
Número de páginas	4
Publicación	Clinical Infectious Diseases
Volumen	59
N.º	9
DOI	https://doi.org/10.1093/cid/ciu642
Estado	Publicada - 01 nov. 2014
Publicado de forma externa	Sí

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Munita, J. M., Mishra, N. N., Alvarez, D., Tran, T. T., Diaz, L., Panesso, D., Reyes, J., Murray, B. E., Adachi, J. A., Bayer, A. S., & Arias, C. A. (2014). Failure of high-dose daptomycin for bacteremia caused by daptomycin-susceptible enterococcus faecium harboring liasr substitutions. Clinical Infectious Diseases, 59(9), 1277-1280. https://doi.org/10.1093/cid/ciu642

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abstract = "High-dose daptomycin (DAP) therapy failed in a neutropenic patient with bloodstream infection caused by a DAP-susceptible Enterococcus faecium (minimum inhibitory concentration, 3 μg/mL) harboring genetic changes associated with DAP resistance, with persistent bacteremia and selection of additional resistances. Daptomycin monotherapy should be used cautiously against DAP-susceptible E. faecium strains with minimum inhibitory concentrations 2 g/mL.",

keywords = "Daptomycin, Enterococcus faecium, resistance, treatment failure",

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doi = "10.1093/cid/ciu642",

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AU - Munita, Jose M.

AU - Mishra, Nagendra N.

AU - Alvarez, Danya

AU - Tran, Truc T.

AU - Diaz, Lorena

AU - Panesso, Diana

AU - Reyes, Jinnethe

AU - Murray, Barbara E.

AU - Adachi, Javier A.

AU - Bayer, Arnold S.

AU - Arias, Cesar A.

PY - 2014/11/1

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KW - Daptomycin

KW - Enterococcus faecium

KW - resistance

KW - treatment failure

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Failure of high-dose daptomycin for bacteremia caused by daptomycin-susceptible enterococcus faecium harboring liasr substitutions

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