TY - JOUR
T1 - Factors associated with oxygen requirement and persistent symptoms 1 year after severe COVID-19 infection
AU - Serrano, María Natalia
AU - Muñoz, Oscar Mauricio
AU - Rueda, Camilo
AU - Arboleda, Alejandra Cañas
AU - Botero, Juan David
AU - Bustos, Marlon Mauricio
N1 - Publisher Copyright:
© The Author(s) 2023.
PY - 2023/5
Y1 - 2023/5
N2 - Objective: We aimed to describe the prevalence and factors associated with the need for supplemental oxygen and persistent symptoms 1 year after severe SARS-CoV-2 infection. Methods: In this historical cohort and nested case–control study, we included adults with severe COVID-19 (requiring admission to the intensive care unit or invasive mechanical ventilation). We evaluated factors associated with a need for supplemental oxygen and persistent symptoms 1 year after severe infection. Results: We included 135 patients (median age 62 years, 30% women). At 1-year follow-up, the main symptoms were dyspnea (32%), myalgia (9%), cough (7%), anxiety (4%), and depression (5%); 12.59% of patients had prolonged requirement for supplemental oxygen. Factors associated with a persistent requirement for supplemental oxygen were female sex (odds ratio 3.15, 95% confidence interval 1.11–8.90) and Charlson Comorbidity Index > 4 (odds ratio 1.60, 95% confidence interval 1.20–2.12). Conclusions: We found that a high prevalence of supplemental oxygen requirement 1 year after severe COVID infection was associated with female sex and a baseline high rate of comorbidities. It is unknown whether this prevalence was related to other factors, such as the altitude at which patients lived. More than half of patients had prolonged post-COVID syndrome.
AB - Objective: We aimed to describe the prevalence and factors associated with the need for supplemental oxygen and persistent symptoms 1 year after severe SARS-CoV-2 infection. Methods: In this historical cohort and nested case–control study, we included adults with severe COVID-19 (requiring admission to the intensive care unit or invasive mechanical ventilation). We evaluated factors associated with a need for supplemental oxygen and persistent symptoms 1 year after severe infection. Results: We included 135 patients (median age 62 years, 30% women). At 1-year follow-up, the main symptoms were dyspnea (32%), myalgia (9%), cough (7%), anxiety (4%), and depression (5%); 12.59% of patients had prolonged requirement for supplemental oxygen. Factors associated with a persistent requirement for supplemental oxygen were female sex (odds ratio 3.15, 95% confidence interval 1.11–8.90) and Charlson Comorbidity Index > 4 (odds ratio 1.60, 95% confidence interval 1.20–2.12). Conclusions: We found that a high prevalence of supplemental oxygen requirement 1 year after severe COVID infection was associated with female sex and a baseline high rate of comorbidities. It is unknown whether this prevalence was related to other factors, such as the altitude at which patients lived. More than half of patients had prolonged post-COVID syndrome.
KW - COVID-19, supplemental oxygen, long COVID, post-COVID syndrome, oxygen requirement, persistent symptom
KW - COVID-19
KW - long COVID
KW - oxygen requirement
KW - persistent symptom
KW - post-COVID syndrome
KW - supplemental oxygen
KW - Humans
KW - Middle Aged
KW - Male
KW - Hospitalization
KW - Case-Control Studies
KW - SARS-CoV-2
KW - COVID-19/epidemiology
KW - Adult
KW - Female
KW - Oxygen/therapeutic use
UR - http://www.scopus.com/inward/record.url?scp=85159130764&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/7798280b-5114-3cbf-b560-b9ab2e06076f/
U2 - 10.1177/03000605231173317
DO - 10.1177/03000605231173317
M3 - Article
C2 - 37170571
AN - SCOPUS:85159130764
SN - 0300-0605
VL - 51
SP - 1
EP - 11
JO - Journal of International Medical Research
JF - Journal of International Medical Research
IS - 5
ER -