TY - GEN
T1 - Effect of maternal use of labetalol on the cerebral autoregulation in premature infants
AU - Caicedo, Alexander
AU - Thewissen, Liesbeth
AU - Naulaers, Gunnar
AU - Lemmers, Petra
AU - Van Bel, Frank
AU - Van Huffel, Sabine
N1 - Funding Information:
The authors would like to thank the Research Council of KUL, GOA MaNet, PFV/10/002 (OPTEC), IDO 08/013 Autism, several PhD/postdoc and fellow grants; the Flemish Government, FWO (PhD/postdoc grants and projects – G.0427.10N (Integrated EEG-fMRI), G.0108.11 (Compressed Sensing) and G.0869.12N (Tumour imaging)); IWT (TBM070713-Accelero, TBM080658-MRI (EEG-fMRI), TBM110697-NeoGuard, PhD grants), IBBT; Flanders Care (Demonstratieproject Tele-Rehab III (2012–2014)); the Belgian Federal Science Policy Office (IUAP P7/(DYSCO, ‘Dynamical systems, control and optimization’, 2012–2017); the ESA AO-PGPF-01, PRODEX (CardioControl) C4000103224; and EU (RECAP 209G within INTERREG IVB NWE programme), EU HIP Trial FP7-HEALTH/2007–2013 (n° 260777) and EU ITN Transact 2012.
PY - 2013
Y1 - 2013
N2 - Hypertensive disorders of pregnancy (HDP) are normally treated to avoid maternal complications. In this study we aimed to investigate if there was an effect of maternal HDP treatment on the cerebral autoregulation of the neonates by analysing measurements of mean arterial blood pressure (MABP) and rScO 2 by means of correlation, coherence, and transfer function analysis. We found that these infants presented higher values of transfer function gain, which indicates impaired cerebral autoregulation, with a decreasing trend towards normality. We hypothesised that this trend was due to a vasodilation effect of the maternal use of labetalol due to accumulation, which disappeared by the third day after birth. Therefore, we investigated the values of pulse pressure in order to find evidence for a vasodilatory effect. We found that lower values of pulse pressure were present in these infants when compared with a control population, which, together with increased transfer function gain values, suggests an effect of the drug on the cerebral autoregulation.
AB - Hypertensive disorders of pregnancy (HDP) are normally treated to avoid maternal complications. In this study we aimed to investigate if there was an effect of maternal HDP treatment on the cerebral autoregulation of the neonates by analysing measurements of mean arterial blood pressure (MABP) and rScO 2 by means of correlation, coherence, and transfer function analysis. We found that these infants presented higher values of transfer function gain, which indicates impaired cerebral autoregulation, with a decreasing trend towards normality. We hypothesised that this trend was due to a vasodilation effect of the maternal use of labetalol due to accumulation, which disappeared by the third day after birth. Therefore, we investigated the values of pulse pressure in order to find evidence for a vasodilatory effect. We found that lower values of pulse pressure were present in these infants when compared with a control population, which, together with increased transfer function gain values, suggests an effect of the drug on the cerebral autoregulation.
UR - http://www.scopus.com/inward/record.url?scp=84934434396&partnerID=8YFLogxK
U2 - 10.1007/978-1-4614-7411-1_15
DO - 10.1007/978-1-4614-7411-1_15
M3 - Conference contribution
C2 - 23852483
AN - SCOPUS:84934434396
SN - 9781461472568
T3 - Advances in Experimental Medicine and Biology
SP - 105
EP - 111
BT - Oxygen Transport to Tissue XXXV
PB - Springer New York LLC
ER -