TY - GEN
T1 - Differences in contraction-induced hemodynamics and surface emg in duchenne muscular dystrophy
AU - Van Ginderdeuren, Eva
AU - Caicedo, Alexander
AU - Taelmans, Joachim
AU - Goemans, Nathalie
AU - Van Den Hauwe, Marlen
AU - Naulaers, Gunnar
AU - Van Huffel, Sabine
AU - Buyse, Gunnar
N1 - Publisher Copyright:
© Springer Science+Business Media, New York 2016.
PY - 2016
Y1 - 2016
N2 - Duchenne muscular dystrophy (DMD) is the most common and devastating type of muscular dystrophy worldwide. In this study we have investigated the potential of the combined use of non-invasive near-infrared spectroscopy (NIRS) and surface electromyography (sEMG) to assess contraction-induced changes in oxygenation and myoelectrical activity, respectively in the biceps brachii of eight DMD patients aged 9–12 years and 11 age-matched healthy controls. Muscle tissue oxygenation index (TOI), oxyhemoglobin (HbO2), and sEMG signals were continuously measured during a sustained submaximal contraction of 60% maximal voluntary isometric contraction, and post-exercise recovery period. Compared to controls, DMD subjects showed significantly smaller changes in TOI during the contraction. In addition, during the reoxygenation phase some dynamic parameters extracted from the HbO2 measurements were significantly different between the two groups, some of which were correlated with functional performances on a 6-min walking test. In conclusion, non-invasive continuous monitoring of skeletal muscle oxygenation by NIRS is feasible in young children, and significant differences in contraction-induced deoxygenation and reoxygenation patterns were observed between healthy controls and DMD children.
AB - Duchenne muscular dystrophy (DMD) is the most common and devastating type of muscular dystrophy worldwide. In this study we have investigated the potential of the combined use of non-invasive near-infrared spectroscopy (NIRS) and surface electromyography (sEMG) to assess contraction-induced changes in oxygenation and myoelectrical activity, respectively in the biceps brachii of eight DMD patients aged 9–12 years and 11 age-matched healthy controls. Muscle tissue oxygenation index (TOI), oxyhemoglobin (HbO2), and sEMG signals were continuously measured during a sustained submaximal contraction of 60% maximal voluntary isometric contraction, and post-exercise recovery period. Compared to controls, DMD subjects showed significantly smaller changes in TOI during the contraction. In addition, during the reoxygenation phase some dynamic parameters extracted from the HbO2 measurements were significantly different between the two groups, some of which were correlated with functional performances on a 6-min walking test. In conclusion, non-invasive continuous monitoring of skeletal muscle oxygenation by NIRS is feasible in young children, and significant differences in contraction-induced deoxygenation and reoxygenation patterns were observed between healthy controls and DMD children.
KW - Duchenne muscular dystrophy
KW - Nirs
KW - Oxygenation
KW - Semg
UR - http://www.scopus.com/inward/record.url?scp=84958554567&partnerID=8YFLogxK
U2 - 10.1007/978-1-4939-3023-4_9
DO - 10.1007/978-1-4939-3023-4_9
M3 - Conference contribution
C2 - 26782197
AN - SCOPUS:84958554567
SN - 9781493930227
T3 - Advances in Experimental Medicine and Biology
SP - 71
EP - 77
BT - Oxygen Transport to Tissue XXXVII
A2 - Elwell, Clare E.
A2 - Leung, Terence S.
A2 - Harrison, David K.
PB - Springer New York LLC
T2 - 42nd Annual Meeting of International Society on Oxygen Transport to Tissue
Y2 - 28 June 2014 through 3 July 2014
ER -