Diagnostic methods in candidemia: A systematic review of literature with meta-analysis

Jorge Alberto Cortés; M. Alejandro Concha; T. Luis Eduardo Cediel; Juan Sebastián Castillo

doi:10.4067/S0716-10182011000600006

Diagnostic methods in candidemia: A systematic review of literature with meta-analysis

Título traducido de la contribución: Métodos diagnósticos en candidemia: Una revisión sistemática de la literatura con meta-análisis

Jorge Alberto Cortés, M. Alejandro Concha, T. Luis Eduardo Cediel, Juan Sebastián Castillo

Universidad Nacional de Colombia

Producción: Contribución a una revista › Artículo de revisión › revisión exhaustiva

4 Citas (Scopus)

Resumen

La candidemia es una patología con alta morbilidad y mortalidad, especialmente en los pacientes sometidos a servicios de cuidado crítico. El diagnóstico precoz permite realizar tratamiento temprano. Objetivos: Realizar una revisión sistemática de la literatura para establecer cuáles son las pruebas de laboratorio con mejor rendimiento diagnóstico y operativo para el diagnóstico de candidemia en cuidado intensivo. Materiales y Métodos: Se realizó una revisión sistemática de la literatura disponible en PubMed, se sometieron a meta-análisis estudios de pruebas serológicas en MetaDisc-Beta 1.1.1. Resultados: Se incluyeron 4 estudios de 1.286 revisados, 3 de pruebas serológicas y 1 de RPC-RT. La sensibilidad y especificidad fue de 87 y 100% para RPC-RT, 47,5 y 82,6% para pruebas de anticuerpos, 96 y 81% para pruebas de antígeno y anticuerpo. La ORD de antigenemia 1,51(IC95% = 0,03270,964; p = 0,001). Conclusiones: RPC-RT tiene mejor rendimiento diagnóstico, la medición de antigenemia más anticuerpos mejora la sensibilidad, especificidad, LR+ y LR-. No hay suficiente evidencia que soporte esto.

Título traducido de la contribución	Métodos diagnósticos en candidemia: Una revisión sistemática de la literatura con meta-análisis
Idioma original	Inglés
Páginas (desde-hasta)	423-428
Número de páginas	6
Publicación	Revista Chilena de Infectologia
Volumen	28
N.º	5
DOI	https://doi.org/10.4067/S0716-10182011000600006
Estado	Publicada - oct. 2011
Publicado de forma externa	Sí

Palabras clave

Fungemia
candidemia
técnicas de diagnóstico molecular
serología
revisión sistemática

ODS de las Naciones Unidas

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10.4067/S0716-10182011000600006

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@article{4068dd870aa64eaabdc3d2f9bee06cfd,

title = "Diagnostic methods in candidemia: A systematic review of literature with meta-analysis",

abstract = "Candidemia is a disease with high morbidity and mortality especially in critical care patients. Early diagnosis enables early treatment. Objectives: To conduct a systematic review of the literature in order to establish the best laboratory tests for the diagnosis of candidemia in critical patients. Materials and Methods: We conducted a systematic review of available literature in PubMed. Serological studies were subjected to meta-analysis in metadisk-Beta 1.1.1. Results: 4 studies of 1286 reviewed were included. Three were about serological tests and one about molecular testing (RT-PCR). The sensitivity and specificity for RT-PCR, antibody testing and antigen and antibody tests were 87% and 100%, 47.5% and 82.6%, 96% and 81%, respectively. Diagnostic Odds Ratio of antigenemia was 1.51 (95% CI = 0,032-70,964, p = 0.001). Conclusions: RT-PCR has better diagnostic performance, measuring antigenemia plus antibodies improves sensitivity, specificity, LR + and LR-¬. There is insufficient evidence to support this.",

keywords = "Candidemia, Fungemia, Molecular diagnostic techniques, Serology, Systematic reviews, Fungemia, candidemia, t{\'e}cnicas de diagn{\'o}stico molecular, serolog{\'i}a, revisi{\'o}n sistem{\'a}tica",

author = "Cort{\'e}s, {Jorge Alberto} and {Alejandro Concha}, M. and {Luis Eduardo Cediel}, T. and Castillo, {Juan Sebasti{\'a}n}",

year = "2011",

month = oct,

doi = "10.4067/S0716-10182011000600006",

language = "English",

volume = "28",

pages = "423--428",

journal = "Revista Chilena de Infectologia",

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TY - JOUR

T1 - Diagnostic methods in candidemia

T2 - A systematic review of literature with meta-analysis

AU - Cortés, Jorge Alberto

AU - Alejandro Concha, M.

AU - Luis Eduardo Cediel, T.

AU - Castillo, Juan Sebastián

PY - 2011/10

Y1 - 2011/10

N2 - Candidemia is a disease with high morbidity and mortality especially in critical care patients. Early diagnosis enables early treatment. Objectives: To conduct a systematic review of the literature in order to establish the best laboratory tests for the diagnosis of candidemia in critical patients. Materials and Methods: We conducted a systematic review of available literature in PubMed. Serological studies were subjected to meta-analysis in metadisk-Beta 1.1.1. Results: 4 studies of 1286 reviewed were included. Three were about serological tests and one about molecular testing (RT-PCR). The sensitivity and specificity for RT-PCR, antibody testing and antigen and antibody tests were 87% and 100%, 47.5% and 82.6%, 96% and 81%, respectively. Diagnostic Odds Ratio of antigenemia was 1.51 (95% CI = 0,032-70,964, p = 0.001). Conclusions: RT-PCR has better diagnostic performance, measuring antigenemia plus antibodies improves sensitivity, specificity, LR + and LR-¬. There is insufficient evidence to support this.

AB - Candidemia is a disease with high morbidity and mortality especially in critical care patients. Early diagnosis enables early treatment. Objectives: To conduct a systematic review of the literature in order to establish the best laboratory tests for the diagnosis of candidemia in critical patients. Materials and Methods: We conducted a systematic review of available literature in PubMed. Serological studies were subjected to meta-analysis in metadisk-Beta 1.1.1. Results: 4 studies of 1286 reviewed were included. Three were about serological tests and one about molecular testing (RT-PCR). The sensitivity and specificity for RT-PCR, antibody testing and antigen and antibody tests were 87% and 100%, 47.5% and 82.6%, 96% and 81%, respectively. Diagnostic Odds Ratio of antigenemia was 1.51 (95% CI = 0,032-70,964, p = 0.001). Conclusions: RT-PCR has better diagnostic performance, measuring antigenemia plus antibodies improves sensitivity, specificity, LR + and LR-¬. There is insufficient evidence to support this.

KW - Candidemia

KW - Fungemia

KW - Molecular diagnostic techniques

KW - Serology

KW - Systematic reviews

KW - Fungemia

KW - candidemia

KW - técnicas de diagnóstico molecular

KW - serología

KW - revisión sistemática

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U2 - 10.4067/S0716-10182011000600006

DO - 10.4067/S0716-10182011000600006

M3 - Review article

C2 - 22051618

AN - SCOPUS:80054934608

SN - 0716-1018

VL - 28

SP - 423

EP - 428

JO - Revista Chilena de Infectologia

JF - Revista Chilena de Infectologia

IS - 5

ER -

Diagnostic methods in candidemia: A systematic review of literature with meta-analysis

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ODS de las Naciones Unidas

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