Dermoscopy of Primary Localized Cutaneous Nodular Amyloidosis

Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare skin condition typified by extracellular dermal deposition of amyloid proteins derived from immunoglobulin light chain L protein released by a localized infiltrate of plasma cells. It usually presents as solitary or multiple asymptomatic nodular lesions and its progression to systematic disease is estimated to occur in approximately 7% of the cases,1–6 thus its recognition is of key importance to prompt diagnose any possible extra-cutaneous involvement. In this regard, dermoscopy has been shown to highlight some findings that may support PLCNA recognition, thereby facilitating the differential diagnosis with its clinical mimickers, mainly including cutaneous lymphomas and granulomatous dermatoses.1–6