DELIVERY OF THERAPEUTIC AGENTS TO THE BONE

Tomatsu Shunji; Adriana M Montano-suarez; Carlos J Almeciga-diaz; Barrera Luis

DELIVERY OF THERAPEUTIC AGENTS TO THE BONE

Tomatsu Shunji (Inventor), Adriana M Montano-suarez (Inventor), Carlos J Almeciga-diaz (Inventor), Barrera Luis (Inventor)

Saint Louis University

Producción: Productos de Innovación › Patente de Invención

Resumen

This invention relates to compositions and methods of delivering therapeutic agents to bone. More specifically, the invention relates to endowing a large molecule vectors i.e., adeno virus, retrovirus, liposomes, micelles, natural and synthetic polymers, or combinations thereof, with the ability to target bone tissue in vivo and with improved stability in the blood, by attaching multiple copies of acid amino acid peptides. One preferred embodiment of the invention relates to endowing an adeno-associated virus (AAV) vector with the ability to target bone-tissue in vivo and improve its stability, by the addition of multiple acidic amino acid peptides attached to the capsid of the viral vector.

Idioma original	Inglés
Número de patente	US 2010/0008979 A1
Clasificación internacional	A61K9/127,A61K31/7088,A61K35/76,A61K38/02,A61K38/46,C12N7/00
Fecha de prioridad	05/07/11
Fecha de introducción	03/07/09
Estado	Publicada - 14 ene. 2010
Publicado de forma externa	Sí

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title = "DELIVERY OF THERAPEUTIC AGENTS TO THE BONE",

abstract = "This invention relates to compositions and methods of delivering therapeutic agents to bone. More specifically, the invention relates to endowing a large molecule vectors i.e., adeno virus, retrovirus, liposomes, micelles, natural and synthetic polymers, or combinations thereof, with the ability to target bone tissue in vivo and with improved stability in the blood, by attaching multiple copies of acid amino acid peptides. One preferred embodiment of the invention relates to endowing an adeno-associated virus (AAV) vector with the ability to target bone-tissue in vivo and improve its stability, by the addition of multiple acidic amino acid peptides attached to the capsid of the viral vector.",

author = "Tomatsu Shunji and Montano-suarez, {Adriana M} and Almeciga-diaz, {Carlos J} and Barrera Luis",

year = "2010",

month = jan,

day = "14",

language = "English",

type = "Patent",

note = "US 2010/0008979 A1; A61K9/127,A61K31/7088,A61K35/76,A61K38/02,A61K38/46,C12N7/00",

}

TY - PAT

T1 - DELIVERY OF THERAPEUTIC AGENTS TO THE BONE

AU - Shunji, Tomatsu

AU - Montano-suarez, Adriana M

AU - Almeciga-diaz, Carlos J

AU - Luis, Barrera

PY - 2010/1/14

Y1 - 2010/1/14

N2 - This invention relates to compositions and methods of delivering therapeutic agents to bone. More specifically, the invention relates to endowing a large molecule vectors i.e., adeno virus, retrovirus, liposomes, micelles, natural and synthetic polymers, or combinations thereof, with the ability to target bone tissue in vivo and with improved stability in the blood, by attaching multiple copies of acid amino acid peptides. One preferred embodiment of the invention relates to endowing an adeno-associated virus (AAV) vector with the ability to target bone-tissue in vivo and improve its stability, by the addition of multiple acidic amino acid peptides attached to the capsid of the viral vector.

AB - This invention relates to compositions and methods of delivering therapeutic agents to bone. More specifically, the invention relates to endowing a large molecule vectors i.e., adeno virus, retrovirus, liposomes, micelles, natural and synthetic polymers, or combinations thereof, with the ability to target bone tissue in vivo and with improved stability in the blood, by attaching multiple copies of acid amino acid peptides. One preferred embodiment of the invention relates to endowing an adeno-associated virus (AAV) vector with the ability to target bone-tissue in vivo and improve its stability, by the addition of multiple acidic amino acid peptides attached to the capsid of the viral vector.

UR - https://www.lens.org/117-070-225-115-615

UR - https://patents.google.com/patent/US20100008979A1/en?oq=US+2010%2f0008979+A1

M3 - Invention patent

M1 - US 2010/0008979 A1

Y2 - 2009/07/03

ER -

DELIVERY OF THERAPEUTIC AGENTS TO THE BONE

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