TY - JOUR
T1 - Cryptic Oral Microbiota
T2 - What Is Its Role as Obstructive Sleep Apnea-Related Periodontal Pathogens?
AU - Téllez Corral, Mayra A.
AU - Herrera Daza, Eddy
AU - Cuervo Jimenez, Hayde K.
AU - Bravo Becerra, María del Mar
AU - Villamil, Jean Carlos
AU - Hidalgo Martinez, Patricia
AU - Roa Molina, Nelly S.
AU - Otero, Liliana
AU - Cortés, María E.
AU - Parra Giraldo, Claudia M.
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/1/18
Y1 - 2023/1/18
N2 - Periodontitis has been commonly linked to periodontopathogens categorized in Socransky’s microbial complexes; however, there is a lack of knowledge regarding “other microorganisms” or “cryptic microorganisms”, which are rarely thought of as significant oral pathogens and have been neither previously categorized nor connected to illnesses in the oral cavity. This study hypothesized that these cryptic microorganisms could contribute to the modulation of oral microbiota present in health or disease (periodontitis and/or obstructive sleep apnea (OSA) patients). For this purpose, the presence and correlation among these cultivable cryptic oral microorganisms were identified, and their possible role in both conditions was determined. Data from oral samples of individuals with or without periodontitis and with or without OSA were obtained from a previous study. Demographic data, clinical oral characteristics, and genera and species of cultivable cryptic oral microorganisms identified by MALDI-TOF were recorded. The data from 75 participants were analyzed to determine the relative frequencies of cultivable cryptic microorganisms’ genera and species, and microbial clusters and correlations tests were performed. According to periodontal condition, dental-biofilm-induced gingivitis in reduced periodontium and stage III periodontitis were found to have the highest diversity of cryptic microorganism species. Based on the experimental condition, these findings showed that there are genera related to disease conditions and others related to healthy conditions, with species that could be related to different chronic diseases being highlighted as periodontitis and OSA comorbidities. The cryptic microorganisms within the oral microbiota of patients with periodontitis and OSA are present as potential pathogens, promoting the development of dysbiotic microbiota and the occurrence of chronic diseases, which have been previously proposed to be common risk factors for periodontitis and OSA. Understanding the function of possible pathogens in the oral microbiota will require more research.
AB - Periodontitis has been commonly linked to periodontopathogens categorized in Socransky’s microbial complexes; however, there is a lack of knowledge regarding “other microorganisms” or “cryptic microorganisms”, which are rarely thought of as significant oral pathogens and have been neither previously categorized nor connected to illnesses in the oral cavity. This study hypothesized that these cryptic microorganisms could contribute to the modulation of oral microbiota present in health or disease (periodontitis and/or obstructive sleep apnea (OSA) patients). For this purpose, the presence and correlation among these cultivable cryptic oral microorganisms were identified, and their possible role in both conditions was determined. Data from oral samples of individuals with or without periodontitis and with or without OSA were obtained from a previous study. Demographic data, clinical oral characteristics, and genera and species of cultivable cryptic oral microorganisms identified by MALDI-TOF were recorded. The data from 75 participants were analyzed to determine the relative frequencies of cultivable cryptic microorganisms’ genera and species, and microbial clusters and correlations tests were performed. According to periodontal condition, dental-biofilm-induced gingivitis in reduced periodontium and stage III periodontitis were found to have the highest diversity of cryptic microorganism species. Based on the experimental condition, these findings showed that there are genera related to disease conditions and others related to healthy conditions, with species that could be related to different chronic diseases being highlighted as periodontitis and OSA comorbidities. The cryptic microorganisms within the oral microbiota of patients with periodontitis and OSA are present as potential pathogens, promoting the development of dysbiotic microbiota and the occurrence of chronic diseases, which have been previously proposed to be common risk factors for periodontitis and OSA. Understanding the function of possible pathogens in the oral microbiota will require more research.
KW - MALDI-TOF
KW - chronic diseases
KW - obstructive sleep apnea
KW - oral microbiota
KW - pathogenic microbiota
KW - periodontitis
KW - Microbiota
KW - Humans
KW - Periodontium
KW - Periodontitis/epidemiology
KW - Sleep Apnea, Obstructive/epidemiology
KW - Gingivitis
UR - http://www.scopus.com/inward/record.url?scp=85147833738&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/d97f79a4-abd0-3b40-be28-5015705687ef/
U2 - 10.3390/ijerph20031740
DO - 10.3390/ijerph20031740
M3 - Article
C2 - 36767109
AN - SCOPUS:85147833738
SN - 1661-7827
VL - 20
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
IS - 3
M1 - 1740
ER -