Confirmation of spotted-fever group and typhus group rickettsiosis cases through a three-month hospital-based sentinel surveillance of acute undifferentiated febrile illness in the municipality of Santander de Quilichao, Cauca, Colombia

Carlos Ramiro Silva-Ramos; Heidy C.Martínez Díaz; Juliana Gil-Mora; Paola Betancourt-Ruiz; Luz Adriana Olaya-M; Eliana Bolaños; Efraín Benavides; Marylin Hidalgo

doi:10.22354/24223794.1235

Confirmation of spotted-fever group and typhus group rickettsiosis cases through a three-month hospital-based sentinel surveillance of acute undifferentiated febrile illness in the municipality of Santander de Quilichao, Cauca, Colombia

Título traducido de la contribución: Confirmación de casos de rickettsiosis del grupo de las fiebres manchadas y del grupo del tifo mediante una vigilancia centinela detres meses en el hospital para síndrome febril agudo indiferenciado en el municipio de Santander de Quilichao, Cauca, Colombia

Carlos Ramiro Silva-Ramos, Heidy C.Martínez Díaz, Juliana Gil-Mora, Paola Betancourt-Ruiz, Luz Adriana Olaya-M, Eliana Bolaños, Efraín Benavides, Marylin Hidalgo

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Resumen

Introducción: Las rickettsiosis del grupo de las fiebres manchadas (GFM) y del grupo del tifo (GT) son causas importantes de síndrome febril agudo indiferenciado (SFAI). Su diagnóstico no se realiza de manera rutinaria, por lo que los estudios de vigilancia que intentan identificar casos activos son de gran importancia. Esta investigación tuvo como objetivo realizar una vigilancia centinela de SFAI en una región con altas tasas de seropositividad en el departamento del Cauca, Colombia. Materiales y Métodos: Se reclutaron pacientes con SFAI durante tres meses en un hospital local del municipio de Santander de Quilichao. Se recolectaron datos demográficos y epidemiológicos. Se obtuvieron muestras agudas y convalecientes de cada paciente. Se realizó un hemograma completo, pruebas de función hepática y medición de proteína C reactiva. Las rickettsiosis del GFM y del GT se tamizaron mediante un ensayo de inmunofluorescencia indirecta. Resultados: Se reclutaron un total de 22 pacientes febriles. En seis de ellos (27,3%) se detectó rickettsiosis del GFM; se detectó rickettsiosis del GT en cuatro (18,2%); y tres (13,6%) se reconvirtieron a ambos grupos de Rickettsia spp. Adicionalmente, en catorce pacientes (93,3%) y once pacientes (73,3%) se evidenció exposición previa a Rickettsia spp. del GFM y del GT. Discusión: Se identificó circulación activa de casos de rickettsiosis del GFM y del GT en áreas rurales de Santander de Quilichao; así como exposición previa a Rickettsia spp., lo que arroja luces sobre una posible nueva región endémica importante para rickettsiosis en Cauca.

Título traducido de la contribución	Confirmación de casos de rickettsiosis del grupo de las fiebres manchadas y del grupo del tifo mediante una vigilancia centinela detres meses en el hospital para síndrome febril agudo indiferenciado en el municipio de Santander de Quilichao, Cauca, Colombia
Idioma original	Inglés
Páginas (desde-hasta)	142-149
Número de páginas	8
Publicación	Infectio
Volumen	29
N.º	3
DOI	https://doi.org/10.22354/24223794.1235
Estado	Publicada - 04 ago. 2025

Palabras clave

Rickettsia
rickettsiosis
grupo de las fiebres manchadas
grupo del tifo
pacientes febriles
Colombia

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10.22354/24223794.1235

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Ramiro Silva-Ramos, C., Díaz, H. C. M., Gil-Mora, J., Betancourt-Ruiz, P., Olaya-M, L. A., Bolaños, E., Benavides, E., & Hidalgo, M. (2025). Confirmation of spotted-fever group and typhus group rickettsiosis cases through a three-month hospital-based sentinel surveillance of acute undifferentiated febrile illness in the municipality of Santander de Quilichao, Cauca, Colombia. Infectio, 29(3), 142-149. https://doi.org/10.22354/24223794.1235

Ramiro Silva-Ramos, Carlos ; Díaz, Heidy C.Martínez ; Gil-Mora, Juliana et al. / Confirmation of spotted-fever group and typhus group rickettsiosis cases through a three-month hospital-based sentinel surveillance of acute undifferentiated febrile illness in the municipality of Santander de Quilichao, Cauca, Colombia. En: Infectio. 2025 ; Vol. 29, N.º 3. pp. 142-149.

@article{454bd877945b4be0996b49a691370535,

title = "Confirmation of spotted-fever group and typhus group rickettsiosis cases through a three-month hospital-based sentinel surveillance of acute undifferentiated febrile illness in the municipality of Santander de Quilichao, Cauca, Colombia",

abstract = "Introduction:Spotted fever group (SFG) and typhus group (TG) rickettsioses are important causes of acute undifferentiated febrile illness (AUFI). Its diagnosis is not routinely performed; thus, surveillance studies that attempt to identify active cases are highly important. The objective of this study was to conduct an AUFI sentinel surveillance in a region with high seropositivity rates in the Cauca Department, Colombia.Materials and Methods: Patients with AUFI were recruited over three months in a local hospital in Santander de Quilichao municipality. Demographic and epidemiologi- cal data were also collected. Acute and convalescent blood samples were collected from each patient. Complete hemograms, liver function tests, and C-reactive protein (CRP) measurements were conducted. SFG and TG rickettsiosis was screened using an indirect immunofluorescence assay.Results: A total of 22 febrile patients were included in this study. In six of them (27.3\%), SFG rickettsiosis was detected; TG rickettsiosis was detected in four (18.2\%) and three (13.6\%) patients seroconverted to both Rickettsia spp. groups. Additionally, in fourteen patients (93.3\%) and eleven patients (73.3\%) patients had previous exposure to SFG and TG Rickettsia spp., respectively.Discussion: Active circulation of SFG and TG rickettsioses cases was identified in rural areas of Santander de Quilichao, as well as previous exposure to Rickettsia spp., shedding light on a possible important novel endemic region for rickettsioses in Cauca.",

keywords = "Colombia, Rickettsia, febrile patients, rickettsiosis, spotted-fever group, typhus group, Rickettsia, rickettsiosis, grupo de las fiebres manchadas, grupo del tifo, pacientes febriles, Colombia",

author = "\{Ramiro Silva-Ramos\}, Carlos and D{\'i}az, \{Heidy C.Mart{\'i}nez\} and Juliana Gil-Mora and Paola Betancourt-Ruiz and Olaya-M, \{Luz Adriana\} and Eliana Bola{\~n}os and Efra{\'i}n Benavides and Marylin Hidalgo",

year = "2025",

month = aug,

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doi = "10.22354/24223794.1235",

language = "English",

volume = "29",

pages = "142--149",

journal = "Infectio",

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Ramiro Silva-Ramos, C, Díaz, HCM, Gil-Mora, J, Betancourt-Ruiz, P, Olaya-M, LA, Bolaños, E, Benavides, E & Hidalgo, M 2025, 'Confirmation of spotted-fever group and typhus group rickettsiosis cases through a three-month hospital-based sentinel surveillance of acute undifferentiated febrile illness in the municipality of Santander de Quilichao, Cauca, Colombia', Infectio, vol. 29, n.º 3, pp. 142-149. https://doi.org/10.22354/24223794.1235

Confirmation of spotted-fever group and typhus group rickettsiosis cases through a three-month hospital-based sentinel surveillance of acute undifferentiated febrile illness in the municipality of Santander de Quilichao, Cauca, Colombia. / Ramiro Silva-Ramos, Carlos; Díaz, Heidy C.Martínez; Gil-Mora, Juliana et al.
En: Infectio, Vol. 29, N.º 3, 04.08.2025, p. 142-149.

Producción: Contribución a una revista › Artículo › revisión exhaustiva

TY - JOUR

T1 - Confirmation of spotted-fever group and typhus group rickettsiosis cases through a three-month hospital-based sentinel surveillance of acute undifferentiated febrile illness in the municipality of Santander de Quilichao, Cauca, Colombia

AU - Ramiro Silva-Ramos, Carlos

AU - Díaz, Heidy C.Martínez

AU - Gil-Mora, Juliana

AU - Betancourt-Ruiz, Paola

AU - Olaya-M, Luz Adriana

AU - Bolaños, Eliana

AU - Benavides, Efraín

AU - Hidalgo, Marylin

PY - 2025/8/4

Y1 - 2025/8/4

N2 - Introduction:Spotted fever group (SFG) and typhus group (TG) rickettsioses are important causes of acute undifferentiated febrile illness (AUFI). Its diagnosis is not routinely performed; thus, surveillance studies that attempt to identify active cases are highly important. The objective of this study was to conduct an AUFI sentinel surveillance in a region with high seropositivity rates in the Cauca Department, Colombia.Materials and Methods: Patients with AUFI were recruited over three months in a local hospital in Santander de Quilichao municipality. Demographic and epidemiologi- cal data were also collected. Acute and convalescent blood samples were collected from each patient. Complete hemograms, liver function tests, and C-reactive protein (CRP) measurements were conducted. SFG and TG rickettsiosis was screened using an indirect immunofluorescence assay.Results: A total of 22 febrile patients were included in this study. In six of them (27.3%), SFG rickettsiosis was detected; TG rickettsiosis was detected in four (18.2%) and three (13.6%) patients seroconverted to both Rickettsia spp. groups. Additionally, in fourteen patients (93.3%) and eleven patients (73.3%) patients had previous exposure to SFG and TG Rickettsia spp., respectively.Discussion: Active circulation of SFG and TG rickettsioses cases was identified in rural areas of Santander de Quilichao, as well as previous exposure to Rickettsia spp., shedding light on a possible important novel endemic region for rickettsioses in Cauca.

AB - Introduction:Spotted fever group (SFG) and typhus group (TG) rickettsioses are important causes of acute undifferentiated febrile illness (AUFI). Its diagnosis is not routinely performed; thus, surveillance studies that attempt to identify active cases are highly important. The objective of this study was to conduct an AUFI sentinel surveillance in a region with high seropositivity rates in the Cauca Department, Colombia.Materials and Methods: Patients with AUFI were recruited over three months in a local hospital in Santander de Quilichao municipality. Demographic and epidemiologi- cal data were also collected. Acute and convalescent blood samples were collected from each patient. Complete hemograms, liver function tests, and C-reactive protein (CRP) measurements were conducted. SFG and TG rickettsiosis was screened using an indirect immunofluorescence assay.Results: A total of 22 febrile patients were included in this study. In six of them (27.3%), SFG rickettsiosis was detected; TG rickettsiosis was detected in four (18.2%) and three (13.6%) patients seroconverted to both Rickettsia spp. groups. Additionally, in fourteen patients (93.3%) and eleven patients (73.3%) patients had previous exposure to SFG and TG Rickettsia spp., respectively.Discussion: Active circulation of SFG and TG rickettsioses cases was identified in rural areas of Santander de Quilichao, as well as previous exposure to Rickettsia spp., shedding light on a possible important novel endemic region for rickettsioses in Cauca.

KW - Colombia

KW - Rickettsia

KW - febrile patients

KW - rickettsiosis

KW - spotted-fever group

KW - typhus group

KW - Rickettsia

KW - rickettsiosis

KW - grupo de las fiebres manchadas

KW - grupo del tifo

KW - pacientes febriles

KW - Colombia

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Ramiro Silva-Ramos C, Díaz HCM, Gil-Mora J, Betancourt-Ruiz P, Olaya-M LA, Bolaños E et al. Confirmation of spotted-fever group and typhus group rickettsiosis cases through a three-month hospital-based sentinel surveillance of acute undifferentiated febrile illness in the municipality of Santander de Quilichao, Cauca, Colombia. Infectio. 2025 ago. 4;29(3):142-149. doi: 10.22354/24223794.1235