Resumen
The prothrombin complex concentrates (PCC) are compounds derived from plasma that incorporates clotting factors dependent on vitamin K. They were developed in 1950 as a source of factor IX for the treatment of hemophilia B and currently their main indication is the reversal of the effects from oral anticoagulants vitamin K antagonists type in emergency situations. Other indications outlined for the use of PCC are the following: replacement therapy for factors II and X in some congenital and acquired defects, coagulopathy associated with severe liver disease, management of perioperative bleeding complications, massive trauma in anticoagulated patients and coagulopathies by sepsis.
Título traducido de la contribución | Prothrombin complex concentrates at the emergency service |
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Idioma original | Español |
Páginas (desde-hasta) | 56-63 |
Número de páginas | 8 |
Publicación | Medicina Interna de Mexico |
Volumen | 30 |
N.º | 1 |
Estado | Publicada - 2014 |
Palabras clave
- Anticoagulation reversal
- Haemorrhage
- Prothrombin complex concentrate