TY - JOUR
T1 - Circulating zinc levels and cardiometabolic risk-related variables in adults
AU - Suárez-Ortegón, Milton Fabián
AU - Arbeláez, Alejandra
AU - Ortega-Ávila, José Guillermo
AU - Mosquera, Mildrey
N1 - Publisher Copyright:
© (2024), (Instituto Nacional de Salud). All rights reserved.
PY - 2024/5/31
Y1 - 2024/5/31
N2 - Introduction. Altered serum zinc levels, lower and higher than values in healthy controls, have been observed in individuals affected by non-communicable chronic diseases. However, to date, studies describing potential determinants of zinc levels in general populations free of chronic diseases appear to be limited. Objective. To evaluate whether nutrient intake, biochemical and clinical measures, lifestyle, and family history of cardio-metabolic diseases are independently associated with zinc levels in apparently healthy individuals. Materials and methods. We evaluated 239 healthy subjects. Serum zinc was measured via flame atomic absorption spectrometry, and the remaining biochemical markers were assessed using enzymatic colorimetric methods. Standard techniques were employed to quantify waist circumference, height, and weight. Body fat was measured via bioimpedance, and blood pressure was measured using digital sphygmomanometers. We applied a survey to record the personal and family history of non-communicable chronic diseases, and nutrient intake was estimated using the 24-hour recall method. Results. Women had lower serum zinc levels than men. In multivariate analyzes, total fat intake (β = -0.15; standard error = 0.03; p < 0.001), plasma log-triglycerides (β = -10.18; standard error = 3.9; p = 0.010), and female gender (β = -6.81; standard error = 3.3; p = 0.043) were significant predictors for serum zinc levels. Zinc intake was not significantly related to serum zinc in univariate and multivariate analyses. Conclusions. Variables related to cardiometabolic risk, such as plasma triglyceride levels and total fat intake, were associated with serum zinc levels in individuals without a diagnosis of chronic or infectious/inflammatory diseases. Further studies are required to confirm our findings and to evaluate possible biological mechanisms for these relationships.
AB - Introduction. Altered serum zinc levels, lower and higher than values in healthy controls, have been observed in individuals affected by non-communicable chronic diseases. However, to date, studies describing potential determinants of zinc levels in general populations free of chronic diseases appear to be limited. Objective. To evaluate whether nutrient intake, biochemical and clinical measures, lifestyle, and family history of cardio-metabolic diseases are independently associated with zinc levels in apparently healthy individuals. Materials and methods. We evaluated 239 healthy subjects. Serum zinc was measured via flame atomic absorption spectrometry, and the remaining biochemical markers were assessed using enzymatic colorimetric methods. Standard techniques were employed to quantify waist circumference, height, and weight. Body fat was measured via bioimpedance, and blood pressure was measured using digital sphygmomanometers. We applied a survey to record the personal and family history of non-communicable chronic diseases, and nutrient intake was estimated using the 24-hour recall method. Results. Women had lower serum zinc levels than men. In multivariate analyzes, total fat intake (β = -0.15; standard error = 0.03; p < 0.001), plasma log-triglycerides (β = -10.18; standard error = 3.9; p = 0.010), and female gender (β = -6.81; standard error = 3.3; p = 0.043) were significant predictors for serum zinc levels. Zinc intake was not significantly related to serum zinc in univariate and multivariate analyses. Conclusions. Variables related to cardiometabolic risk, such as plasma triglyceride levels and total fat intake, were associated with serum zinc levels in individuals without a diagnosis of chronic or infectious/inflammatory diseases. Further studies are required to confirm our findings and to evaluate possible biological mechanisms for these relationships.
KW - Zinc
KW - factores de riesgo de enfermedad cardiaca
KW - heart disease risk factors
KW - micronutrientes
KW - micronutrients
KW - triglicéridos
KW - triglycerides
KW - zinc
KW - Cross-Sectional Studies
KW - Humans
KW - Middle Aged
KW - Risk Factors
KW - Male
KW - Young Adult
KW - Cardiometabolic Risk Factors
KW - Zinc/blood
KW - Triglycerides/blood
KW - Female
KW - Adult
KW - Cardiovascular Diseases/etiology
KW - zinc
KW - factores de riesgo de enfermedad cardiaca
KW - triglicéridos
KW - micronutrientes
UR - http://dx.doi.org/10.7705/biomedica.6882
UR - https://www.mendeley.com/catalogue/5b15ed4b-6c2e-3557-93d3-d303236b2005/
U2 - 10.7705/biomedica.6882
DO - 10.7705/biomedica.6882
M3 - Article
C2 - 39079151
AN - SCOPUS:85200194551
SN - 0120-4157
VL - 44
SP - 63
EP - 72
JO - Biomedica
JF - Biomedica
IS - Sp 1
ER -