TY - JOUR
T1 - Birth Defects and Mortality-Related Factors in Colombia
T2 - Insights from a Surveillance Cohort (2002-2019)
AU - Pineda-Sanabria, Pablo
AU - Portilla-Rojas, Esteban
AU - Arbelaez-Hoyos, Catalina
AU - Baquero-Castro, Valentina
AU - Lores, Juliana
AU - Sarmiento, Karen
AU - Zarante, Ignacio
N1 - Publisher Copyright:
© The Author(s) 2025. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
PY - 2025/10
Y1 - 2025/10
N2 - Introduction: Birth defects are a leading cause of neonatal mortality worldwide, particularly in low- and middle-income countries. In Latin America, longitudinal studies on BD prevalence and mortality remain limited. Objectives: To describe BD epidemiology in Bogotá and Cali (2002-2019), focusing on prevalence, in-hospital mortality, and associated maternal and neonatal factors. Methods: We conducted a retrospective, population-based cohort study using PREVERDEC surveillance data from 558 057 births, following Latin American Collaborative Study of Congenital Malformations (ECLAMC) methodology. BD prevalence was expressed per 10 000 live births, and Cox regression identified mortality risk factors. Results: BD prevalence was 126.8 (95% CI: 123.9-129.8) per 10 000 live births, with musculoskeletal anomalies most common. Neonatal mortality was 0.26 per 1000 live births. Mortality risk was higher in preterm infants, those with major BD, and circulatory system defects. Conclusion: This study provides updated evidence on BD in Colombia, highlighting risk factors for adverse outcomes.
AB - Introduction: Birth defects are a leading cause of neonatal mortality worldwide, particularly in low- and middle-income countries. In Latin America, longitudinal studies on BD prevalence and mortality remain limited. Objectives: To describe BD epidemiology in Bogotá and Cali (2002-2019), focusing on prevalence, in-hospital mortality, and associated maternal and neonatal factors. Methods: We conducted a retrospective, population-based cohort study using PREVERDEC surveillance data from 558 057 births, following Latin American Collaborative Study of Congenital Malformations (ECLAMC) methodology. BD prevalence was expressed per 10 000 live births, and Cox regression identified mortality risk factors. Results: BD prevalence was 126.8 (95% CI: 123.9-129.8) per 10 000 live births, with musculoskeletal anomalies most common. Neonatal mortality was 0.26 per 1000 live births. Mortality risk was higher in preterm infants, those with major BD, and circulatory system defects. Conclusion: This study provides updated evidence on BD in Colombia, highlighting risk factors for adverse outcomes.
KW - Birth defects
KW - Colombia
KW - Congenital abnormalities
KW - Mortality
KW - Public health
UR - https://www.scopus.com/pages/publications/105019963724
U2 - 10.1177/30502225251383338
DO - 10.1177/30502225251383338
M3 - Article
AN - SCOPUS:105019963724
SN - 3050-2225
VL - 12
SP - 1
EP - 9
JO - Sage Open Pediatrics
JF - Sage Open Pediatrics
M1 - 30502225251383338
ER -
