Biomarkers for dementia in Latin American countries: Gaps and opportunities

Mario A. Parra; Paulina Orellana; Tomas Leon; Cabello G. Victoria; Fernando Henriquez; Rodrigo Gomez; Constanza Avalos; Andres Damian; Andrea Slachevsky; Agustin Ibañez; Henrik Zetterberg; Betty M. Tijms; Jennifer S. Yokoyama; Stefanie D. Piña-Escudero; J. Nicholas Cochran; Diana L. Matallana; Daisy Acosta; Ricardo Allegri; Bianca P. Arias-Suárez; Bernardo Barra; Maria Isabel Behrens; Sonia M.D. Brucki; Geraldo Busatto; Paulo Caramelli; Sheila Castro-Suarez; Valeria Contreras; Nilton Custodio; Sergio Dansilio; Myriam De la Cruz-Puebla; Leonardo Cruz de Souza; Monica M. Diaz; Lissette Duque; Gonzalo A. Farías; Sergio T. Ferreira; Nahuel Magrath Guimet; Ana Kmaid; David Lira; Francisco Lopera; Beatriz Mar Meza; Eliane C. Miotto; Ricardo Nitrini; Alberto Nuñez; Santiago O'Neill; John Ochoa; Maritza Pintado-Caipa; Elisa de Paula França Resende; Shannon Risacher; Luz Angela Rojas; Valentina Sabaj; Lucas Schilling; Allis F. Sellek; Ana Sosa; Leonel T. Takada; Antonio L. Teixeira; Martha Unaucho-Pilalumbo; Claudia Duran-Aniotz

doi:10.1002/alz.12757

Biomarkers for dementia in Latin American countries: Gaps and opportunities

Mario A. Parra, Paulina Orellana, Tomas Leon, Cabello G. Victoria, Fernando Henriquez, Rodrigo Gomez, Constanza Avalos, Andres Damian, Andrea Slachevsky, Agustin Ibañez, Henrik Zetterberg, Betty M. Tijms, Jennifer S. Yokoyama, Stefanie D. Piña-Escudero, J. Nicholas Cochran, Diana L. Matallana, Daisy Acosta, Ricardo Allegri, Bianca P. Arias-Suárez, Bernardo BarraMaria Isabel Behrens, Sonia M.D. Brucki, Geraldo Busatto, Paulo Caramelli, Sheila Castro-Suarez, Valeria Contreras, Nilton Custodio, Sergio Dansilio, Myriam De la Cruz-Puebla, Leonardo Cruz de Souza, Monica M. Diaz, Lissette Duque, Gonzalo A. Farías, Sergio T. Ferreira, Nahuel Magrath Guimet, Ana Kmaid, David Lira, Francisco Lopera, Beatriz Mar Meza, Eliane C. Miotto, Ricardo Nitrini, Alberto Nuñez, Santiago O'Neill, John Ochoa, Maritza Pintado-Caipa, Elisa de Paula França Resende, Shannon Risacher, Luz Angela Rojas, Valentina Sabaj, Lucas Schilling, Allis F. Sellek, Ana Sosa, Leonel T. Takada, Antonio L. Teixeira, Martha Unaucho-Pilalumbo, Claudia Duran-Aniotz

Instituto de Envejecimiento

Producción: Contribución a una revista › Artículo › revisión exhaustiva

23 Citas (Scopus)

Resumen

Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The results show that neuroimaging is the most used biomarker (73%), followed by genetic studies (40%), peripheral fluids biomarkers (31%), and cerebrospinal fluid biomarkers (29%). Regarding barriers in LAC, lack of funding appears to undermine the implementation of biomarkers in clinical or research settings, followed by insufficient infrastructure and training. The survey revealed that despite the above barriers, the region holds a great potential to advance dementia biomarkers research. Considering the unique contributions that LAC could make to this growing field, we highlight the urgent need to expand biomarker research. These insights allowed us to propose an action plan that addresses the recommendations for a biomarker framework recently proposed by regional experts.

Idioma original	Inglés
Páginas (desde-hasta)	721-735
Número de páginas	15
Publicación	Alzheimer's and Dementia
Volumen	19
N.º	2
DOI	https://doi.org/10.1002/alz.12757
Estado	Publicada - feb. 2023

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Parra, M. A., Orellana, P., Leon, T., Victoria, C. G., Henriquez, F., Gomez, R., Avalos, C., Damian, A., Slachevsky, A., Ibañez, A., Zetterberg, H., Tijms, B. M., Yokoyama, J. S., Piña-Escudero, S. D., Cochran, J. N., Matallana, D. L., Acosta, D., Allegri, R., Arias-Suárez, B. P., ... Duran-Aniotz, C. (2023). Biomarkers for dementia in Latin American countries: Gaps and opportunities. Alzheimer's and Dementia, 19(2), 721-735. https://doi.org/10.1002/alz.12757

@article{2b79f27c22c143fab9a70a75138c22a0,

title = "Biomarkers for dementia in Latin American countries: Gaps and opportunities",

abstract = "Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The results show that neuroimaging is the most used biomarker (73%), followed by genetic studies (40%), peripheral fluids biomarkers (31%), and cerebrospinal fluid biomarkers (29%). Regarding barriers in LAC, lack of funding appears to undermine the implementation of biomarkers in clinical or research settings, followed by insufficient infrastructure and training. The survey revealed that despite the above barriers, the region holds a great potential to advance dementia biomarkers research. Considering the unique contributions that LAC could make to this growing field, we highlight the urgent need to expand biomarker research. These insights allowed us to propose an action plan that addresses the recommendations for a biomarker framework recently proposed by regional experts.",

author = "Parra, {Mario A.} and Paulina Orellana and Tomas Leon and Victoria, {Cabello G.} and Fernando Henriquez and Rodrigo Gomez and Constanza Avalos and Andres Damian and Andrea Slachevsky and Agustin Iba{\~n}ez and Henrik Zetterberg and Tijms, {Betty M.} and Yokoyama, {Jennifer S.} and Pi{\~n}a-Escudero, {Stefanie D.} and Cochran, {J. Nicholas} and Matallana, {Diana L.} and Daisy Acosta and Ricardo Allegri and Arias-Su{\'a}rez, {Bianca P.} and Bernardo Barra and Behrens, {Maria Isabel} and Brucki, {Sonia M.D.} and Geraldo Busatto and Paulo Caramelli and Sheila Castro-Suarez and Valeria Contreras and Nilton Custodio and Sergio Dansilio and {la Cruz-Puebla}, {Myriam De} and {de Souza}, {Leonardo Cruz} and Diaz, {Monica M.} and Lissette Duque and Far{\'i}as, {Gonzalo A.} and Ferreira, {Sergio T.} and Guimet, {Nahuel Magrath} and Ana Kmaid and David Lira and Francisco Lopera and Meza, {Beatriz Mar} and Miotto, {Eliane C.} and Ricardo Nitrini and Alberto Nu{\~n}ez and Santiago O'Neill and John Ochoa and Maritza Pintado-Caipa and Resende, {Elisa de Paula Fran{\c c}a} and Shannon Risacher and Rojas, {Luz Angela} and Valentina Sabaj and Lucas Schilling and Sellek, {Allis F.} and Ana Sosa and Takada, {Leonel T.} and Teixeira, {Antonio L.} and Martha Unaucho-Pilalumbo and Claudia Duran-Aniotz",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.",

year = "2023",

month = feb,

doi = "10.1002/alz.12757",

language = "English",

volume = "19",

pages = "721--735",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "John Wiley and Sons Inc.",

number = "2",

}

Parra, MA, Orellana, P, Leon, T, Victoria, CG, Henriquez, F, Gomez, R, Avalos, C, Damian, A, Slachevsky, A, Ibañez, A, Zetterberg, H, Tijms, BM, Yokoyama, JS, Piña-Escudero, SD, Cochran, JN, Matallana, DL, Acosta, D, Allegri, R, Arias-Suárez, BP, Barra, B, Behrens, MI, Brucki, SMD, Busatto, G, Caramelli, P, Castro-Suarez, S, Contreras, V, Custodio, N, Dansilio, S, la Cruz-Puebla, MD, de Souza, LC, Diaz, MM, Duque, L, Farías, GA, Ferreira, ST, Guimet, NM, Kmaid, A, Lira, D, Lopera, F, Meza, BM, Miotto, EC, Nitrini, R, Nuñez, A, O'Neill, S, Ochoa, J, Pintado-Caipa, M, Resende, EDPF, Risacher, S, Rojas, LA, Sabaj, V, Schilling, L, Sellek, AF, Sosa, A, Takada, LT, Teixeira, AL, Unaucho-Pilalumbo, M & Duran-Aniotz, C 2023, 'Biomarkers for dementia in Latin American countries: Gaps and opportunities', Alzheimer's and Dementia, vol. 19, n.º 2, pp. 721-735. https://doi.org/10.1002/alz.12757

TY - JOUR

T1 - Biomarkers for dementia in Latin American countries

T2 - Gaps and opportunities

AU - Parra, Mario A.

AU - Orellana, Paulina

AU - Leon, Tomas

AU - Victoria, Cabello G.

AU - Henriquez, Fernando

AU - Gomez, Rodrigo

AU - Avalos, Constanza

AU - Damian, Andres

AU - Slachevsky, Andrea

AU - Ibañez, Agustin

AU - Zetterberg, Henrik

AU - Tijms, Betty M.

AU - Yokoyama, Jennifer S.

AU - Piña-Escudero, Stefanie D.

AU - Cochran, J. Nicholas

AU - Matallana, Diana L.

AU - Acosta, Daisy

AU - Allegri, Ricardo

AU - Arias-Suárez, Bianca P.

AU - Barra, Bernardo

AU - Behrens, Maria Isabel

AU - Brucki, Sonia M.D.

AU - Busatto, Geraldo

AU - Caramelli, Paulo

AU - Castro-Suarez, Sheila

AU - Contreras, Valeria

AU - Custodio, Nilton

AU - Dansilio, Sergio

AU - la Cruz-Puebla, Myriam De

AU - de Souza, Leonardo Cruz

AU - Diaz, Monica M.

AU - Duque, Lissette

AU - Farías, Gonzalo A.

AU - Ferreira, Sergio T.

AU - Guimet, Nahuel Magrath

AU - Kmaid, Ana

AU - Lira, David

AU - Lopera, Francisco

AU - Meza, Beatriz Mar

AU - Miotto, Eliane C.

AU - Nitrini, Ricardo

AU - Nuñez, Alberto

AU - O'Neill, Santiago

AU - Ochoa, John

AU - Pintado-Caipa, Maritza

AU - Resende, Elisa de Paula França

AU - Risacher, Shannon

AU - Rojas, Luz Angela

AU - Sabaj, Valentina

AU - Schilling, Lucas

AU - Sellek, Allis F.

AU - Sosa, Ana

AU - Takada, Leonel T.

AU - Teixeira, Antonio L.

AU - Unaucho-Pilalumbo, Martha

AU - Duran-Aniotz, Claudia

PY - 2023/2

Y1 - 2023/2

N2 - Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The results show that neuroimaging is the most used biomarker (73%), followed by genetic studies (40%), peripheral fluids biomarkers (31%), and cerebrospinal fluid biomarkers (29%). Regarding barriers in LAC, lack of funding appears to undermine the implementation of biomarkers in clinical or research settings, followed by insufficient infrastructure and training. The survey revealed that despite the above barriers, the region holds a great potential to advance dementia biomarkers research. Considering the unique contributions that LAC could make to this growing field, we highlight the urgent need to expand biomarker research. These insights allowed us to propose an action plan that addresses the recommendations for a biomarker framework recently proposed by regional experts.

AB - Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The results show that neuroimaging is the most used biomarker (73%), followed by genetic studies (40%), peripheral fluids biomarkers (31%), and cerebrospinal fluid biomarkers (29%). Regarding barriers in LAC, lack of funding appears to undermine the implementation of biomarkers in clinical or research settings, followed by insufficient infrastructure and training. The survey revealed that despite the above barriers, the region holds a great potential to advance dementia biomarkers research. Considering the unique contributions that LAC could make to this growing field, we highlight the urgent need to expand biomarker research. These insights allowed us to propose an action plan that addresses the recommendations for a biomarker framework recently proposed by regional experts.

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U2 - 10.1002/alz.12757

DO - 10.1002/alz.12757

M3 - Article

C2 - 36098676

AN - SCOPUS:85138014229

SN - 1552-5260

VL - 19

SP - 721

EP - 735

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

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ER -

Biomarkers for dementia in Latin American countries: Gaps and opportunities

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