TY - JOUR
T1 - Association of apolipoprotein E variants on Alzheimer's disease in Latin America
T2 - A systematic review and meta-analysis
AU - Orellana, Paulina
AU - Caviedes, Ariel
AU - Gonzalez, Liset
AU - Ochoa-Rosales, Carolina
AU - Carmona, Danilo
AU - González-Silva, Carolina
AU - Hernández, Hernán
AU - Britton, Gabrielle B.
AU - Villarreal, Alcibiades E.
AU - Campos, Victoria
AU - Hendrie, Hugh
AU - Acosta-Uribe, Juliana
AU - Pina-Escudero, Stefanie D.
AU - Yokoyama, Jennifer S.
AU - Vilor-Tejedor, Natalia
AU - Parra, Mario
AU - Santamaria-García, Hernando
AU - Ibañez, Agustín
AU - de la Cruz, Rolando
AU - Duran-Aniotz, Claudia
N1 - Publisher Copyright:
© 2026 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
© 2026 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2026/2/1
Y1 - 2026/2/1
N2 - The apolipoprotein E (APOE) ε4 allele represents the strongest genetic risk factor for Alzheimer's disease (AD), but its role in genetically diverse Latin American and Caribbean (LAC) populations is underexplored. We conducted a meta-analysis of 35 studies from 11 LAC countries, encompassing 3206 patients with AD and 5515 controls. The ε4 allele demonstrated significant association with increased AD risk (odds ratio [OR] = 3.25, 95% confidence interval [2.82–3.76]), while ε3 showed lower odds (0.42, [0.37–0.48]). Homozygous ε4/ε4 carriers had elevated risk (6.84, [5.09–9.19]), and heterozygous ε3/ε4 carriers showed moderate risk (2.59, [2.31–2.91]). Country-level analyses revealed variability, with Ecuador showing the highest OR for ε4/ε4 (13.29, [1.56–113.4]). These results confirm APOE ε4 as a major AD risk factor in LAC populations and highlight regional differences relevant to precision medicine.
AB - The apolipoprotein E (APOE) ε4 allele represents the strongest genetic risk factor for Alzheimer's disease (AD), but its role in genetically diverse Latin American and Caribbean (LAC) populations is underexplored. We conducted a meta-analysis of 35 studies from 11 LAC countries, encompassing 3206 patients with AD and 5515 controls. The ε4 allele demonstrated significant association with increased AD risk (odds ratio [OR] = 3.25, 95% confidence interval [2.82–3.76]), while ε3 showed lower odds (0.42, [0.37–0.48]). Homozygous ε4/ε4 carriers had elevated risk (6.84, [5.09–9.19]), and heterozygous ε3/ε4 carriers showed moderate risk (2.59, [2.31–2.91]). Country-level analyses revealed variability, with Ecuador showing the highest OR for ε4/ε4 (13.29, [1.56–113.4]). These results confirm APOE ε4 as a major AD risk factor in LAC populations and highlight regional differences relevant to precision medicine.
KW - Alzheimer's disease
KW - Caribbean
KW - Latin America
KW - genetic risk factors
KW - meta-analysis
KW - systematic review
UR - https://www.scopus.com/pages/publications/105030577856
UR - https://www.mendeley.com/catalogue/88d0d163-ba5d-3887-9b22-b01d494ba945/
U2 - 10.1002/alz.71224
DO - 10.1002/alz.71224
M3 - Article
C2 - 41724662
AN - SCOPUS:105030577856
SN - 1552-5260
VL - 22
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 2
M1 - e71224
ER -
ODS 3: Salud y bienestar