Association between comorbid anxiety and depression symptomatology, quality of life, social support and use of mental health services in youth from Bogota, Buenos Aires, and Lima

Ana L. Vilela-Estrada; Maria Lazo-Porras; Antonio Bernabe-Ortiz; Stefan Priebe; Victoria J. Bird; Karen Ariza-Salazar; Diliniya Stanislaus Sureshkumar; Natalia Godoy-Casasbuenas; Carlos Gómez-Restrepo; Natividad Olivar; Sofia Madero; Luis Ignacio Brusco; Francisco Diez-Canseco

doi:10.1016/j.jad.2025.120305

Association between comorbid anxiety and depression symptomatology, quality of life, social support and use of mental health services in youth from Bogota, Buenos Aires, and Lima

Título traducido de la contribución: Asociación entre la sintomatología comórbida de ansiedad y depresión, calidad de vida, apoyo social y uso de servicios de salud mental en jóvenes de Bogotá, Buenos Aires y Lima

Ana L. Vilela-Estrada, Maria Lazo-Porras, Antonio Bernabe-Ortiz, Stefan Priebe, Victoria J. Bird, Karen Ariza-Salazar, Diliniya Stanislaus Sureshkumar, Natalia Godoy-Casasbuenas, Carlos Gómez-Restrepo, Natividad Olivar, Sofia Madero, Luis Ignacio Brusco, Francisco Diez-Canseco

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Resumen

Objetivo
Este estudio tuvo como objetivo (1) examinar la asociación entre la ansiedad comórbida y los síntomas depresivos y la calidad de vida (CdV) entre adolescentes y adultos jóvenes y evaluar si el apoyo social percibido modifica esta relación; y (2) explorar la asociación entre los síntomas comórbidos y el uso de servicios de salud mental (SM), considerando la CdV como un posible modificador del efecto.

Métodos
Se realizó un estudio transversal con 1816 adolescentes y adultos jóvenes de 15 a 24 años de zonas urbanas con desventaja socioeconómica de Bogotá, Buenos Aires y Lima. El análisis incluyó estadística descriptiva, pruebas bivariadas y modelos lineales generalizados multivariables para evaluar la asociación con la calidad de vida. Se utilizaron modelos de regresión de Poisson para examinar la asociación con el uso de servicios de salud mental. Se incluyeron términos de interacción para evaluar la posible modificación del efecto por el apoyo social y la calidad de vida, ajustando todos los modelos a factores de confusión sociodemográficos y contextuales relevantes.

Resultados
La comorbilidad de los síntomas depresivos y ansiosos se asoció con puntuaciones más bajas de QoL (β = −0,71; p < 0,001). Un mayor apoyo social percibido se asoció positivamente con QoL y moderó significativamente la relación entre comorbilidad y QoL ( p < 0,001). Además, la comorbilidad se relacionó con un mayor uso de los servicios de salud mental (RP = 1,98; p < 0,001). Cada punto adicional de QoL se asoció con una reducción del 25 % en el uso de servicios de salud mental (p < 0,001); pero la QoL no modificó la asociación entre la comorbilidad y el uso de servicios, a pesar de estar cerca de la significancia ( p = 0,063).

Discusión
Abordar tanto los síntomas emocionales como los factores sociales es esencial para mejorar el bienestar de los jóvenes. Los hallazgos respaldan el fortalecimiento de las redes de apoyo social y la ampliación del acceso a los servicios para los grupos vulnerables.

Título traducido de la contribución	Asociación entre la sintomatología comórbida de ansiedad y depresión, calidad de vida, apoyo social y uso de servicios de salud mental en jóvenes de Bogotá, Buenos Aires y Lima
Idioma original	Inglés
Número de artículo	120305
Páginas (desde-hasta)	1-11
Número de páginas	11
Publicación	Journal of Affective Disorders
Volumen	393
N.º	Part A
DOI	https://doi.org/10.1016/j.jad.2025.120305
Estado	Publicada - 15 ene. 2026

Palabras clave

Comorbilidad
Ansiedad
Depresión
Calidad de vida
Servicios de apoyo social y salud mental

ODS de las Naciones Unidas

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Vilela-Estrada, A. L., Lazo-Porras, M., Bernabe-Ortiz, A., Priebe, S., Bird, V. J., Ariza-Salazar, K., Sureshkumar, D. S., Godoy-Casasbuenas, N., Gómez-Restrepo, C., Olivar, N., Madero, S., Brusco, L. I., & Diez-Canseco, F. (2026). Association between comorbid anxiety and depression symptomatology, quality of life, social support and use of mental health services in youth from Bogota, Buenos Aires, and Lima. Journal of Affective Disorders, 393(Part A), 1-11. Artículo 120305. https://doi.org/10.1016/j.jad.2025.120305

@article{d8fe8bb479984f969d0417aa807e36fe,

title = "Association between comorbid anxiety and depression symptomatology, quality of life, social support and use of mental health services in youth from Bogota, Buenos Aires, and Lima",

abstract = "PURPOSE: This study aimed to (1) examine the association between comorbid anxiety and depressive symptoms and quality of life (QoL) among adolescents and young adults and assess whether perceived social support modifies this relationship; and (2) explore the association between comorbid symptoms and use of mental health (MH) services, considering QoL as a potential effect modifier.METHODS: A cross-sectional study was conducted with 1816 adolescents and young adults aged 15-24 years from socioeconomically disadvantaged urban areas of Bogot{\'a}, Buenos Aires, and Lima. The analysis included descriptive statistics, bivariate tests, and multivariable generalised linear models to assess associations with QoL. Poisson regression models were used to examine the association with MH service use. Interaction terms were included to assess potential effect modification by social support and QoL, with all models adjusted for relevant sociodemographic and contextual confounders.RESULTS: Comorbidity of depressive and anxiety symptoms was associated with lower QoL scores (β = -0.71; p < 0.001). Higher perceived social support was positively associated with QoL and significantly moderated the comorbidity and QoL relationship (p < 0.001). Additionally, comorbidity was linked to increased use of MH services (PR = 1.98; p < 0.001). Each QoL additional point was associated with a reduction of 25 \% in MH service use (p < 0.001); but QoL did not modify the association between comorbidity and service use, despite being close to significance (p = 0.063).DISCUSSION: Addressing both emotional symptoms and social factors is essential for improving youth well-being. Findings support strengthening social support networks and expanding access to services for vulnerable groups.",

keywords = "Anxiety, Comorbidity, Depression, Quality of life, Social support and mental health services, Comorbilidad, Ansiedad, Depresi{\'o}n, Calidad de vida, Servicios de apoyo social y salud mental",

author = "Vilela-Estrada, \{Ana L.\} and Maria Lazo-Porras and Antonio Bernabe-Ortiz and Stefan Priebe and Bird, \{Victoria J.\} and Karen Ariza-Salazar and Sureshkumar, \{Diliniya Stanislaus\} and Natalia Godoy-Casasbuenas and Carlos G{\'o}mez-Restrepo and Natividad Olivar and Sofia Madero and Brusco, \{Luis Ignacio\} and Francisco Diez-Canseco",

note = "Copyright {\textcopyright} 2025. Published by Elsevier B.V.",

year = "2026",

month = jan,

day = "15",

doi = "10.1016/j.jad.2025.120305",

language = "English",

volume = "393",

pages = "1--11",

journal = "Journal of Affective Disorders",

issn = "0165-0327",

publisher = "Elsevier B.V.",

number = "Part A",

}

Vilela-Estrada, AL, Lazo-Porras, M, Bernabe-Ortiz, A, Priebe, S, Bird, VJ, Ariza-Salazar, K, Sureshkumar, DS, Godoy-Casasbuenas, N , Gómez-Restrepo, C, Olivar, N, Madero, S, Brusco, LI & Diez-Canseco, F 2026, 'Association between comorbid anxiety and depression symptomatology, quality of life, social support and use of mental health services in youth from Bogota, Buenos Aires, and Lima', Journal of Affective Disorders, vol. 393, n.º Part A, 120305, pp. 1-11. https://doi.org/10.1016/j.jad.2025.120305

Association between comorbid anxiety and depression symptomatology, quality of life, social support and use of mental health services in youth from Bogota, Buenos Aires, and Lima. / Vilela-Estrada, Ana L.; Lazo-Porras, Maria; Bernabe-Ortiz, Antonio et al.
En: Journal of Affective Disorders, Vol. 393, N.º Part A, 120305, 15.01.2026, p. 1-11.

Producción: Contribución a una revista › Artículo › revisión exhaustiva

TY - JOUR

T1 - Association between comorbid anxiety and depression symptomatology, quality of life, social support and use of mental health services in youth from Bogota, Buenos Aires, and Lima

AU - Vilela-Estrada, Ana L.

AU - Lazo-Porras, Maria

AU - Bernabe-Ortiz, Antonio

AU - Priebe, Stefan

AU - Bird, Victoria J.

AU - Ariza-Salazar, Karen

AU - Sureshkumar, Diliniya Stanislaus

AU - Godoy-Casasbuenas, Natalia

AU - Gómez-Restrepo, Carlos

AU - Olivar, Natividad

AU - Madero, Sofia

AU - Brusco, Luis Ignacio

AU - Diez-Canseco, Francisco

PY - 2026/1/15

Y1 - 2026/1/15

N2 - PURPOSE: This study aimed to (1) examine the association between comorbid anxiety and depressive symptoms and quality of life (QoL) among adolescents and young adults and assess whether perceived social support modifies this relationship; and (2) explore the association between comorbid symptoms and use of mental health (MH) services, considering QoL as a potential effect modifier.METHODS: A cross-sectional study was conducted with 1816 adolescents and young adults aged 15-24 years from socioeconomically disadvantaged urban areas of Bogotá, Buenos Aires, and Lima. The analysis included descriptive statistics, bivariate tests, and multivariable generalised linear models to assess associations with QoL. Poisson regression models were used to examine the association with MH service use. Interaction terms were included to assess potential effect modification by social support and QoL, with all models adjusted for relevant sociodemographic and contextual confounders.RESULTS: Comorbidity of depressive and anxiety symptoms was associated with lower QoL scores (β = -0.71; p < 0.001). Higher perceived social support was positively associated with QoL and significantly moderated the comorbidity and QoL relationship (p < 0.001). Additionally, comorbidity was linked to increased use of MH services (PR = 1.98; p < 0.001). Each QoL additional point was associated with a reduction of 25 % in MH service use (p < 0.001); but QoL did not modify the association between comorbidity and service use, despite being close to significance (p = 0.063).DISCUSSION: Addressing both emotional symptoms and social factors is essential for improving youth well-being. Findings support strengthening social support networks and expanding access to services for vulnerable groups.

AB - PURPOSE: This study aimed to (1) examine the association between comorbid anxiety and depressive symptoms and quality of life (QoL) among adolescents and young adults and assess whether perceived social support modifies this relationship; and (2) explore the association between comorbid symptoms and use of mental health (MH) services, considering QoL as a potential effect modifier.METHODS: A cross-sectional study was conducted with 1816 adolescents and young adults aged 15-24 years from socioeconomically disadvantaged urban areas of Bogotá, Buenos Aires, and Lima. The analysis included descriptive statistics, bivariate tests, and multivariable generalised linear models to assess associations with QoL. Poisson regression models were used to examine the association with MH service use. Interaction terms were included to assess potential effect modification by social support and QoL, with all models adjusted for relevant sociodemographic and contextual confounders.RESULTS: Comorbidity of depressive and anxiety symptoms was associated with lower QoL scores (β = -0.71; p < 0.001). Higher perceived social support was positively associated with QoL and significantly moderated the comorbidity and QoL relationship (p < 0.001). Additionally, comorbidity was linked to increased use of MH services (PR = 1.98; p < 0.001). Each QoL additional point was associated with a reduction of 25 % in MH service use (p < 0.001); but QoL did not modify the association between comorbidity and service use, despite being close to significance (p = 0.063).DISCUSSION: Addressing both emotional symptoms and social factors is essential for improving youth well-being. Findings support strengthening social support networks and expanding access to services for vulnerable groups.

KW - Anxiety

KW - Comorbidity

KW - Depression

KW - Quality of life

KW - Social support and mental health services

KW - Comorbilidad

KW - Ansiedad

KW - Depresión

KW - Calidad de vida

KW - Servicios de apoyo social y salud mental

UR - https://www.scopus.com/pages/publications/105015614214

UR - https://www.mendeley.com/catalogue/65fab5d8-85c8-3242-8955-c987c8cb976f/

U2 - 10.1016/j.jad.2025.120305

DO - 10.1016/j.jad.2025.120305

M3 - Article

C2 - 40939997

AN - SCOPUS:105015614214

SN - 0165-0327

VL - 393

SP - 1

EP - 11

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

IS - Part A

M1 - 120305

ER -

Vilela-Estrada AL, Lazo-Porras M, Bernabe-Ortiz A, Priebe S, Bird VJ, Ariza-Salazar K et al. Association between comorbid anxiety and depression symptomatology, quality of life, social support and use of mental health services in youth from Bogota, Buenos Aires, and Lima. Journal of Affective Disorders. 2026 ene. 15;393(Part A):1-11. 120305. doi: 10.1016/j.jad.2025.120305

Association between comorbid anxiety and depression symptomatology, quality of life, social support and use of mental health services in youth from Bogota, Buenos Aires, and Lima

Resumen

Palabras clave

ODS de las Naciones Unidas

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