@inproceedings{79633fd050d64e4b9713123905dea755,
title = "Analysis of binding residues between PDGF-BB and epidermal growth factor receptor: A computational docking study",
abstract = "A directed docking was performed using Cluspro between human PDGF-BB and EGFR using specific templates obtained from PDB. Various conserved residues were found to be involved in the docking interaction of the complex by means of hydrophobic interactions and hydrogen bonds. An electrostatic potential evaluation of the PDGF-BB-EGFR complex was also performed to validate if the complex is electrostatically complementary in the binding area. Results suggested a possible binding mechanism which could explain the in vivo evidence of formation of heterodimeric receptors EGFR-PDGFR.",
keywords = "Docking, EGFR, Interactions, PDGF-BB, Transactivation",
author = "Ricardo Cabezas and Daniel Torrente and Avila, {Marco Fidel} and Jannet Gonz{\'a}lez and Barreto, {George Emilio}",
year = "2014",
doi = "10.1007/978-3-319-01568-2_5",
language = "English",
isbn = "9783319015675",
series = "Advances in Intelligent Systems and Computing",
publisher = "Springer Verlag",
pages = "29--39",
booktitle = "Advances in Computational Biology - Proceedings of the 2nd Colombian Congress on Computational Biology and Bioinformatics CCBCOL 2013",
address = "Germany",
note = "2nd Colombian Congress on Computational Biology and Bioinformatics, CCBCOL 2013 ; Conference date: 25-09-2013 Through 27-09-2013",
}