A synthetic vaccine protects humans against challenge with asexual blood stages of Plasmodium falciparum malaria

Manuel E. Patarroyo; Roberto Amador; Pedro Clavijo; Alberto Moreno; Fanny Guzman; Pedro Romero; Ricardo Tascon; Antonio Franco; Luis A. Murillo; Gabriel Ponton; Gustavo Trujillo

doi:10.1038/332158a0

A synthetic vaccine protects humans against challenge with asexual blood stages of Plasmodium falciparum malaria

Manuel E. Patarroyo, Roberto Amador, Pedro Clavijo, Alberto Moreno, Fanny Guzman, Pedro Romero, Ricardo Tascon, Antonio Franco, Luis A. Murillo, Gabriel Ponton, Gustavo Trujillo

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348 Citas (Scopus)

Resumen

We have previously shown that a mixture of three synthetic peptides (83.1, 55.1, 35.1), corresponding to fragments of the relative molecular mass 83,000 (83K), 55K and 35K Plasmodium falciparum merozoite-specific proteins, induces protection in Aotus trivirpatus monkeys experimentally infected with P. falciparum^1,2. Here we describe two polymeric synthetic hybrid proteins based on these peptides that delay or suppress the development of parasitaemia in immunized human volunteers.

Idioma original	Inglés
Páginas (desde-hasta)	158-161
Número de páginas	4
Publicación	Nature
Volumen	332
N.º	6160
DOI	https://doi.org/10.1038/332158a0
Estado	Publicada - 1988
Publicado de forma externa	Sí

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title = "A synthetic vaccine protects humans against challenge with asexual blood stages of Plasmodium falciparum malaria",

abstract = "We have previously shown that a mixture of three synthetic peptides (83.1, 55.1, 35.1), corresponding to fragments of the relative molecular mass 83,000 (83K), 55K and 35K Plasmodium falciparum merozoite-specific proteins, induces protection in Aotus trivirpatus monkeys experimentally infected with P. falciparum1,2. Here we describe two polymeric synthetic hybrid proteins based on these peptides that delay or suppress the development of parasitaemia in immunized human volunteers.",

author = "Patarroyo, {Manuel E.} and Roberto Amador and Pedro Clavijo and Alberto Moreno and Fanny Guzman and Pedro Romero and Ricardo Tascon and Antonio Franco and Murillo, {Luis A.} and Gabriel Ponton and Gustavo Trujillo",

year = "1988",

doi = "10.1038/332158a0",

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T1 - A synthetic vaccine protects humans against challenge with asexual blood stages of Plasmodium falciparum malaria

AU - Patarroyo, Manuel E.

AU - Amador, Roberto

AU - Clavijo, Pedro

AU - Moreno, Alberto

AU - Guzman, Fanny

AU - Romero, Pedro

AU - Tascon, Ricardo

AU - Franco, Antonio

AU - Murillo, Luis A.

AU - Ponton, Gabriel

AU - Trujillo, Gustavo

PY - 1988

Y1 - 1988

N2 - We have previously shown that a mixture of three synthetic peptides (83.1, 55.1, 35.1), corresponding to fragments of the relative molecular mass 83,000 (83K), 55K and 35K Plasmodium falciparum merozoite-specific proteins, induces protection in Aotus trivirpatus monkeys experimentally infected with P. falciparum1,2. Here we describe two polymeric synthetic hybrid proteins based on these peptides that delay or suppress the development of parasitaemia in immunized human volunteers.

AB - We have previously shown that a mixture of three synthetic peptides (83.1, 55.1, 35.1), corresponding to fragments of the relative molecular mass 83,000 (83K), 55K and 35K Plasmodium falciparum merozoite-specific proteins, induces protection in Aotus trivirpatus monkeys experimentally infected with P. falciparum1,2. Here we describe two polymeric synthetic hybrid proteins based on these peptides that delay or suppress the development of parasitaemia in immunized human volunteers.

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U2 - 10.1038/332158a0

DO - 10.1038/332158a0

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VL - 332

SP - 158

EP - 161

JO - Nature

JF - Nature

IS - 6160

ER -

A synthetic vaccine protects humans against challenge with asexual blood stages of Plasmodium falciparum malaria

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