A liaf codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecalis

Jose M. Munita; Truc T. Tran; Lorena Diaz; Diana Panesso; Jinnethe Reyes; Barbara E. Murray; Cesar A. Ariasa

doi:10.1128/AAC.00021-13

A liaf codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecalis

Jose M. Munita, Truc T. Tran, Lorena Diaz, Diana Panesso, Jinnethe Reyes, Barbara E. Murray, Cesar A. Ariasa

Producción: Contribución a una revista › Artículo › revisión exhaustiva

59 Citas (Scopus)

Resumen

The genetic bases for antibiotic tolerance are obscure. Daptomycin (DAP) is a lipopeptide antibiotic with bactericidal activity against enterococci. Using time-kill assays, we provide evidence for the first time that a deletion of isoleucine in position 177 of LiaF, a member of the three-component regulatory system LiaFSR involved in the cell envelope response to antimicrobials, is directly responsible for a DAP-tolerant phenotype and is likely to negatively affect response to DAP therapy.

Idioma original	Inglés
Páginas (desde-hasta)	2831-2833
Número de páginas	3
Publicación	Antimicrobial Agents and Chemotherapy
Volumen	57
N.º	6
DOI	https://doi.org/10.1128/AAC.00021-13
Estado	Publicada - jun. 2013
Publicado de forma externa	Sí

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abstract = "The genetic bases for antibiotic tolerance are obscure. Daptomycin (DAP) is a lipopeptide antibiotic with bactericidal activity against enterococci. Using time-kill assays, we provide evidence for the first time that a deletion of isoleucine in position 177 of LiaF, a member of the three-component regulatory system LiaFSR involved in the cell envelope response to antimicrobials, is directly responsible for a DAP-tolerant phenotype and is likely to negatively affect response to DAP therapy.",

author = "Munita, \{Jose M.\} and Tran, \{Truc T.\} and Lorena Diaz and Diana Panesso and Jinnethe Reyes and Murray, \{Barbara E.\} and Ariasa, \{Cesar A.\}",

year = "2013",

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language = "English",

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AU - Munita, Jose M.

AU - Tran, Truc T.

AU - Diaz, Lorena

AU - Panesso, Diana

AU - Reyes, Jinnethe

AU - Murray, Barbara E.

AU - Ariasa, Cesar A.

PY - 2013/6

Y1 - 2013/6

N2 - The genetic bases for antibiotic tolerance are obscure. Daptomycin (DAP) is a lipopeptide antibiotic with bactericidal activity against enterococci. Using time-kill assays, we provide evidence for the first time that a deletion of isoleucine in position 177 of LiaF, a member of the three-component regulatory system LiaFSR involved in the cell envelope response to antimicrobials, is directly responsible for a DAP-tolerant phenotype and is likely to negatively affect response to DAP therapy.

AB - The genetic bases for antibiotic tolerance are obscure. Daptomycin (DAP) is a lipopeptide antibiotic with bactericidal activity against enterococci. Using time-kill assays, we provide evidence for the first time that a deletion of isoleucine in position 177 of LiaF, a member of the three-component regulatory system LiaFSR involved in the cell envelope response to antimicrobials, is directly responsible for a DAP-tolerant phenotype and is likely to negatively affect response to DAP therapy.

UR - https://www.scopus.com/pages/publications/84877854867

U2 - 10.1128/AAC.00021-13

DO - 10.1128/AAC.00021-13

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 6

ER -

A liaf codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecalis

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