A liaf codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecalis

Jose M. Munita; Truc T. Tran; Lorena Diaz; Diana Panesso; Jinnethe Reyes; Barbara E. Murray; Cesar A. Ariasa

doi:10.1128/AAC.00021-13

A liaf codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecalis

Jose M. Munita, Truc T. Tran, Lorena Diaz, Diana Panesso, Jinnethe Reyes, Barbara E. Murray, Cesar A. Ariasa

Producción: Contribución a una revista › Artículo › revisión exhaustiva

58 Citas (Scopus)

Resumen

The genetic bases for antibiotic tolerance are obscure. Daptomycin (DAP) is a lipopeptide antibiotic with bactericidal activity against enterococci. Using time-kill assays, we provide evidence for the first time that a deletion of isoleucine in position 177 of LiaF, a member of the three-component regulatory system LiaFSR involved in the cell envelope response to antimicrobials, is directly responsible for a DAP-tolerant phenotype and is likely to negatively affect response to DAP therapy.

Idioma original	Inglés
Páginas (desde-hasta)	2831-2833
Número de páginas	3
Publicación	Antimicrobial Agents and Chemotherapy
Volumen	57
N.º	6
DOI	https://doi.org/10.1128/AAC.00021-13
Estado	Publicada - jun. 2013
Publicado de forma externa	Sí

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Acceder al documento

10.1128/AAC.00021-13

Otros archivos y enlaces

Enlace a la publicación en Scopus

Citar esto

@article{70b7aa5a90824b3bb3a72f5aa816942a,

title = "A liaf codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecalis",

abstract = "The genetic bases for antibiotic tolerance are obscure. Daptomycin (DAP) is a lipopeptide antibiotic with bactericidal activity against enterococci. Using time-kill assays, we provide evidence for the first time that a deletion of isoleucine in position 177 of LiaF, a member of the three-component regulatory system LiaFSR involved in the cell envelope response to antimicrobials, is directly responsible for a DAP-tolerant phenotype and is likely to negatively affect response to DAP therapy.",

author = "Munita, {Jose M.} and Tran, {Truc T.} and Lorena Diaz and Diana Panesso and Jinnethe Reyes and Murray, {Barbara E.} and Ariasa, {Cesar A.}",

year = "2013",

month = jun,

doi = "10.1128/AAC.00021-13",

language = "English",

volume = "57",

pages = "2831--2833",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "6",

}

TY - JOUR

T1 - A liaf codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecalis

AU - Munita, Jose M.

AU - Tran, Truc T.

AU - Diaz, Lorena

AU - Panesso, Diana

AU - Reyes, Jinnethe

AU - Murray, Barbara E.

AU - Ariasa, Cesar A.

PY - 2013/6

Y1 - 2013/6

N2 - The genetic bases for antibiotic tolerance are obscure. Daptomycin (DAP) is a lipopeptide antibiotic with bactericidal activity against enterococci. Using time-kill assays, we provide evidence for the first time that a deletion of isoleucine in position 177 of LiaF, a member of the three-component regulatory system LiaFSR involved in the cell envelope response to antimicrobials, is directly responsible for a DAP-tolerant phenotype and is likely to negatively affect response to DAP therapy.

AB - The genetic bases for antibiotic tolerance are obscure. Daptomycin (DAP) is a lipopeptide antibiotic with bactericidal activity against enterococci. Using time-kill assays, we provide evidence for the first time that a deletion of isoleucine in position 177 of LiaF, a member of the three-component regulatory system LiaFSR involved in the cell envelope response to antimicrobials, is directly responsible for a DAP-tolerant phenotype and is likely to negatively affect response to DAP therapy.

UR - http://www.scopus.com/inward/record.url?scp=84877854867&partnerID=8YFLogxK

U2 - 10.1128/AAC.00021-13

DO - 10.1128/AAC.00021-13

M3 - Article

C2 - 23507277

AN - SCOPUS:84877854867

SN - 0066-4804

VL - 57

SP - 2831

EP - 2833

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 6

ER -

A liaf codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecalis

Resumen

ODS de las Naciones Unidas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto