Resumen
In this paper, we generalize a previous model of within-host dengue
infection with a nonconstant monocyte production rate. We establish
the existence of three equilibria and give some local stability
results. We then estimate three parameters in the model from clinical
data for dengue virus serotype 2. It is then shown that the model
can exhibit behaviours that are not possible under the assumption of
constant monocyte production. Lastly, we perform a sensitivity analysis
of the model in two contexts, antiviral treatment and immunostimulatory
treatment. The results predict that antiviral treatments
that reduce the viral replication rate in infected monocytes are the
most effective, while immunostimulatory treatments that increase
the rate at which infected monocytes are removed are best
infection with a nonconstant monocyte production rate. We establish
the existence of three equilibria and give some local stability
results. We then estimate three parameters in the model from clinical
data for dengue virus serotype 2. It is then shown that the model
can exhibit behaviours that are not possible under the assumption of
constant monocyte production. Lastly, we perform a sensitivity analysis
of the model in two contexts, antiviral treatment and immunostimulatory
treatment. The results predict that antiviral treatments
that reduce the viral replication rate in infected monocytes are the
most effective, while immunostimulatory treatments that increase
the rate at which infected monocytes are removed are best
Título traducido de la contribución | Un modelo generalizado de infección por dengue con una tasa de producción de monocitos no constante |
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Idioma original | Inglés |
Páginas (desde-hasta) | 143-161 |
Número de páginas | 19 |
Publicación | Journal of Biological Dynamics |
Volumen | 14 |
N.º | 1 |
DOI | |
Estado | Publicada - 01 ene. 2020 |
Palabras clave
- Dengue
- within-host model
- reproductive rate
- Clinical Data