Arns largos no codificantes circulantes asociados con la funcion de celulas β pancreaticas y su relacion con la resistencia a la insulina en adultos.

The pancreatic β cells are essential for the control of blood glucose level by insulin secretion, the dysfunction of these cells is considered a determining factor in the development of insulin resistance and Type 2 diabetes mellitus. Recently different studies had reported pancreatic β cells express specifically certain long noncoding RNas (lncRNas) which have the potential to be used as molecular biomarkers to follow the function of these cells in blood. However, this issue still remains to be addressed. aim: To evaluate the presence in blood of long noncoding RNas specifically expressed by pancreatic β cells and their relation with insulin resistance and function of β islet . Methodology Thirty subjects (15 men and 15 women) apparently healthy, will be recruited on the campus of the PUJ-Cali with aged 20-60 years. Subjects who are agreed to participate, will be cited to get the fasting blood samples to measure the expression of lncRNas candidates, insulin and glucose concentration to calculate indices HOMa-IR and HOMa-B. anthropometric data of height, weight, waist circumference and survey on family history of chronic non-communicable diseases will also be taken. an statistical and bioinformatics approach will be applied to the analysis of the variants, and the molecular descriptions of lncRNas.