TY - GEN
T1 - Volume of tissue activated in patients with parkinson's disease from west-center region of Colombia treated with deep brain stimulation
AU - Cardona, Hernán Darío Vargas
AU - Álvarez, Mauricio A.
AU - Daza, Genaro
AU - Guijarro, Enrique
AU - Orozco, Álvaro
PY - 2014
Y1 - 2014
N2 - Parkinson's Disease (PD) is a group of neurological disorders caused by a deficiency of dopamine in a brain structure called Substantia Nigra Reticulata (SNR). The neurosurgical procedure known as Deep Brain Stimulation (DBS) of Subthalamic Nucleus (STN) has proved to be an effective treatment for this disease. DBS modulates neural activity with electric fields. However, the mechanisms regulating the therapeutic effects of DBS are not clear, in fact there is not a full knowledge about the voltage distribution generated in the brain by the stimulating electrodes, what is usually named as Volume of Tissue Activated (VTA). VTA is useful to find the optimal parameters of stimulation, that allow the neurosurgeons to get the best clinical outcomes and minimal side effects. In this work, we applied a methodology to estimate the VTA, based on analysis of diffusion tensor images (DTI) of PD patients from the west-center region of Colombia. DTI are used to characterize the conductivity of brain structures relevant in DBS. The results are consistent to similar studies in other populations.
AB - Parkinson's Disease (PD) is a group of neurological disorders caused by a deficiency of dopamine in a brain structure called Substantia Nigra Reticulata (SNR). The neurosurgical procedure known as Deep Brain Stimulation (DBS) of Subthalamic Nucleus (STN) has proved to be an effective treatment for this disease. DBS modulates neural activity with electric fields. However, the mechanisms regulating the therapeutic effects of DBS are not clear, in fact there is not a full knowledge about the voltage distribution generated in the brain by the stimulating electrodes, what is usually named as Volume of Tissue Activated (VTA). VTA is useful to find the optimal parameters of stimulation, that allow the neurosurgeons to get the best clinical outcomes and minimal side effects. In this work, we applied a methodology to estimate the VTA, based on analysis of diffusion tensor images (DTI) of PD patients from the west-center region of Colombia. DTI are used to characterize the conductivity of brain structures relevant in DBS. The results are consistent to similar studies in other populations.
KW - Deep brain stimulation (DBS)
KW - Diffusion tensor images (DTI)
KW - Parkinson's disease (PD)
KW - Subthalamic nucleus(STN)
KW - Volume of tissue activated (VTA)
UR - http://www.scopus.com/inward/record.url?scp=84891281467&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-00846-2_45
DO - 10.1007/978-3-319-00846-2_45
M3 - Conference contribution
AN - SCOPUS:84891281467
SN - 9783319008455
T3 - IFMBE Proceedings
SP - 182
EP - 185
BT - 13th Mediterranean Conference on Medical and Biological Engineering and Computing 2013 - MEDICON 2013
PB - Springer Verlag
T2 - 13th Mediterranean Conference on Medical and Biological Engineering and Computing 2013, MEDICON 2013
Y2 - 25 September 2013 through 28 September 2013
ER -