TY - JOUR
T1 - Vitamin D-binding protein polymorphisms are not associated with development of (multiple) basal cell carcinomas
AU - Flohil, Sophie C.
AU - De Vries, Esther
AU - Van Meurs, Joyce B.J.
AU - Fang, Yue
AU - Stricker, Bruno H.Ch
AU - Uitterlinden, André G.
AU - Nijsten, Tamar
PY - 2010/12
Y1 - 2010/12
N2 - Vitamin D-binding protein (VDBP) single nucleotide polymorphisms (SNP) may affect skin carcinogenesis. The objective was to test the association between two functional VDBP SNPs and the susceptibility to (multiple) basal cell carcinomas (BCCs). Of the 7983 participants, 5790 (72.5%) and 5823 (72.9%) participants were genotyped for rs7041 and rs4588, respectively, and three haplotypes (Gc1s, Gc2 and Gc1f) were analysed. Two hundred and thirty-three persons developed a BCC of whom 122 (52.4%) developed multiple BCCs during a mean follow-up of 11.6 years. The VDBP genotype was not associated with (multiple) BCC development using Cox proportional hazards and Andersen-Gill analyses, respectively. Stratifying age groups demonstrated that in the youngest age-group, the A/T variant of rs7041 was associated with BCC development [adjusted hazard ratio (HR) = 1.88 (95%CI 1.10-3.20)], while homozygote Gc1s carriers had a significantly lower BCC risk [adjusted HR = 0.53 (95%CI 0.31-0.91)]. In conclusion, the VDBP polymorphisms were not associated with susceptibility to (multiple) BCCs, but age-gene interactions were observed.
AB - Vitamin D-binding protein (VDBP) single nucleotide polymorphisms (SNP) may affect skin carcinogenesis. The objective was to test the association between two functional VDBP SNPs and the susceptibility to (multiple) basal cell carcinomas (BCCs). Of the 7983 participants, 5790 (72.5%) and 5823 (72.9%) participants were genotyped for rs7041 and rs4588, respectively, and three haplotypes (Gc1s, Gc2 and Gc1f) were analysed. Two hundred and thirty-three persons developed a BCC of whom 122 (52.4%) developed multiple BCCs during a mean follow-up of 11.6 years. The VDBP genotype was not associated with (multiple) BCC development using Cox proportional hazards and Andersen-Gill analyses, respectively. Stratifying age groups demonstrated that in the youngest age-group, the A/T variant of rs7041 was associated with BCC development [adjusted hazard ratio (HR) = 1.88 (95%CI 1.10-3.20)], while homozygote Gc1s carriers had a significantly lower BCC risk [adjusted HR = 0.53 (95%CI 0.31-0.91)]. In conclusion, the VDBP polymorphisms were not associated with susceptibility to (multiple) BCCs, but age-gene interactions were observed.
KW - Age-gene interaction
KW - Basal cell carcinoma (BCC)
KW - Polymorphism
KW - Vitamin D-binding protein (VDBP)
UR - http://www.scopus.com/inward/record.url?scp=78649519478&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0625.2010.01139.x
DO - 10.1111/j.1600-0625.2010.01139.x
M3 - Letter
C2 - 20812960
AN - SCOPUS:78649519478
SN - 0906-6705
VL - 19
SP - 1103
EP - 1105
JO - Experimental Dermatology
JF - Experimental Dermatology
IS - 12
ER -