Towards a Global View of Parkinson's Disease Genetics

Marzieh Khani; Catalina Cerquera-Cleves; Mariam Kekenadze; Peter Wild Crea; Andrew B. Singleton; Sara Bandres-Ciga

doi:10.1002/ana.26905

Towards a Global View of Parkinson's Disease Genetics

Marzieh Khani
, Catalina Cerquera-Cleves
, Mariam Kekenadze
, Peter Wild Crea
, Andrew B. Singleton
, Sara Bandres-Ciga

National Institutes of Health
Université Laval
Tbilisi State Medical University
University College London

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

Parkinson's disease (PD) is a global health challenge, yet historically studies of PD have taken place predominantly in European populations. Recent genetics research conducted in non-European populations has revealed novel population-specific genetic loci linked to PD risk, highlighting the importance of studying PD globally. These insights have broadened our understanding of PD etiology, which is crucial for developing disease-modifying interventions. This review comprehensively explores the global genetic landscape of PD, emphasizing the scientific rationale for studying underrepresented populations. It underscores challenges, such as genotype–phenotype heterogeneity and inclusion difficulties for non-European participants, emphasizing the ongoing need for diverse and inclusive research in PD. ANN NEUROL 2024;95:831–842.

Original language	English
Pages (from-to)	831-842
Number of pages	12
Journal	Annals of Neurology
Volume	95
Issue number	5
DOIs	https://doi.org/10.1002/ana.26905
State	Published - May 2024

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title = "Towards a Global View of Parkinson's Disease Genetics",

abstract = "Parkinson's disease (PD) is a global health challenge, yet historically studies of PD have taken place predominantly in European populations. Recent genetics research conducted in non-European populations has revealed novel population-specific genetic loci linked to PD risk, highlighting the importance of studying PD globally. These insights have broadened our understanding of PD etiology, which is crucial for developing disease-modifying interventions. This review comprehensively explores the global genetic landscape of PD, emphasizing the scientific rationale for studying underrepresented populations. It underscores challenges, such as genotype–phenotype heterogeneity and inclusion difficulties for non-European participants, emphasizing the ongoing need for diverse and inclusive research in PD. ANN NEUROL 2024;95:831–842.",

author = "Marzieh Khani and Catalina Cerquera-Cleves and Mariam Kekenadze and \{Wild Crea\}, Peter and Singleton, \{Andrew B.\} and Sara Bandres-Ciga",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.",

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AU - Khani, Marzieh

AU - Cerquera-Cleves, Catalina

AU - Kekenadze, Mariam

AU - Wild Crea, Peter

AU - Singleton, Andrew B.

AU - Bandres-Ciga, Sara

N1 - Publisher Copyright: © 2024 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.

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AB - Parkinson's disease (PD) is a global health challenge, yet historically studies of PD have taken place predominantly in European populations. Recent genetics research conducted in non-European populations has revealed novel population-specific genetic loci linked to PD risk, highlighting the importance of studying PD globally. These insights have broadened our understanding of PD etiology, which is crucial for developing disease-modifying interventions. This review comprehensively explores the global genetic landscape of PD, emphasizing the scientific rationale for studying underrepresented populations. It underscores challenges, such as genotype–phenotype heterogeneity and inclusion difficulties for non-European participants, emphasizing the ongoing need for diverse and inclusive research in PD. ANN NEUROL 2024;95:831–842.

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JO - Annals of Neurology

JF - Annals of Neurology

IS - 5

ER -

Towards a Global View of Parkinson's Disease Genetics

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